Citations : Haemagglutinin stability was not the primary cause of the reduced effectiveness of live attenuated influenza vaccine against A/H1N1pdm09 viruses in the 2013–2014 and 2015–2016 seasons

Dated: Jul 26, 2020

Publication Name: Vaccine

In these studies, we confirm that the A/CA09 LAIV virus is more temperature and pH unstable than historical LAIV influenza A viruses with proven VE. These remain a possible contributing factor to A/CA09 reduced VE against circulating A/H1N1pdm09 strains. We also demonstrate that the A/BOL13 HA protein has a comparable pH and thermostability profile to historically efficacious influenza A LAIV strains. As suboptimal VE was still observed for A/BOL13, despite its improved pH and thermostability profile, we suggest that while an important consideration in CVV selection, HA stability was not the primary cause of the reduced effectiveness of LAIV against A/H1N1pdm09 viruses in the 2013–2014 and 2015–2016 influenza seasons.

Read More

Contributors: Lauren Parker, Lydia Ritter, WenWu1, RubenMaeso2, Helen Bright, Oliver Dibben