The Kroemer Lab is interested in the molecular mechanisms of cellular stress and death. The mode of cellular stress and death that is evoked during cancer treatment has profound therapeutic implications. A systematic search has been launched to identify molecular switches that “decide” which particular cell stress or cell death subroutine is preferentially executed. In addition, cancer cell death modalities and their impact on the immune system are analyzed in a systematic fashion to develop strategies that improve the chances of therapeutic success.
The Cell Biology platform (pictured, right) within the Kroemer Lab is used as a hub to conduct screening approaches as it offers fully automated cell biology workflows that allow for the phenotypic screening of large-scale compound and siRNA libraries. They use a battery of fluorescent biosensor cells to assess all types of cellular stress and death.
To enable this cutting-edge research, the group needed a high-content analysis system that they could fully integrate into an automated platform which also includes compound management and automated cell culture.Read More