ClonePix 2 System

Number of Citations*: 472

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High-throughput ClonePix FL analysis of mAb-expressing clones using the UCOE expression system

JJC Hou, BS Hughes, M Smede, KM Leung, K Levine… - New biotechnology, 2014 - Elsevier

Therapeutic recombinant monoclonal antibodies (mAbs) are commonly produced by high-expressing, clonal, mammalian cells. Creation of these clones for manufacturing remains heavily reliant on stringent selection and gene amplification, which in turn can lead to …

Cited by 38 Related articles All 8 versions

Sequential screening by ClonePix FL and intracellular staining facilitate isolation of high producer cell lines for monoclonal antibody manufacturing

G Roy, G Miro-Quesada, L Zhuang, T Martin… - Journal of …, 2017 - Elsevier

Screening and characterization of cell lines for stable production are critical tasks in identifying suitable recombinant cell lines for the manufacture of protein therapeutics. To aid this essential function we have developed a methodology for the selection of antibody …

Cited by 5 Related articles All 6 versions [PDF]

Rapid isolation of antigen-specific clones from hybridoma fusions

CJ Mann - Nature Methods, 2007 -

… The Genetix ClonePix FL is a powerful way to find and collect antigen-specific clones from hybridoma fusions in a rapid one-step process—shortening the process timeline and allowing parallel interrogation of multiple antigens in the monoclonal antibody discovery process …

Cited by 11 Related articles All 3 versions