Citations : Analysis of P/N leak subtraction of pClamp acquisition software

Dated: Oct 01, 2000

Publication Name: Acta Physiologica Sinica

Using blind whole cell recording technique on rat hippocampal slices, the function and mechanisms of P/N leak subtraction of Clampex program in pClamp acquisition software were studied. The ways of picking up sub-pulse current and properly selecting parameters, including time course, polarization, sub-holding potential, numbers and location of P/N sub-pulse were analyzed in detail. Our results indicate that voltage-gated ion channel currents recorded by Clampex will be more accurate and reproducible by properly using P/N leak subtraction.

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Contributors: Sheng li xue bao : [Acta Physiologica Sinica]