Citations : Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole

Dated: Dec 29, 2013

Publication Name: Molecular and Cellular Biochemistry volume

Drug repositioning has been considered a promising approach to discover novel treatments against neglected diseases. Among the major protozoan diseases, leishmaniasis remains a public health threat with few therapeutic alternatives, affecting 12 million people in 98 countries. In this study, we report the in vitro antileishmanial activity of the imidazole drugs clotrimazole, and for the first time in literature, econazole and bifonazole and their potential action to affect the regulation of reactive oxygen species (ROS) of the parasites. The lethal action of the imidazoles was investigated using spectrofluorimetric techniques to detect ROS content, plasma membrane permeability, and mitochondrial membrane potential. The imidazoles showed activity against L.

Read More

Contributors: Juliana Tonini Mesquita, Thais Alves da Costa-Silva, Samanta Etel Treiger Borborema & André Gustavo Tempone