The MultiWash+™ Microplate Washer is an automated, compact, quiet, efficient washer with 20 different wash protocol options. The variations include adjustable speed and volume, adjustable aspiration speed and time, adjustable soak times, and three modes of shaking. Four wash/rinse bottles are included and configurable for both 96- and 384-well plates.
Achieve efficient washing with cross-wise aspiration and reduce residual volume within each well. The washer is vacuum and pressure free, with on-board pumps for a quiet wash experience.
The washer can dispense in 50-μL increments and tubing can be inserted into a variety of containers because pressurized bottles are not required.
Gain benefits of a microplate washer for lower throughput applications and any assay that needs washing as a primary, intermediary, or final step before quantitation.
The 20 different wash protocols include up to eight cycles within each protocol for walk-up usability and flexibility.
Settings include adjustable speed and volume, adjustable aspiration speed and time, and adjustable soak times, with three modes of shaking available to mix solutions.
Advancements in genetic engineering and synthetic biology have allowed numerous breakthroughs in recent decades. The importance of cell line development needs an honorable mention.…
The worldwide COVID-19 pandemic caused by the SARS-CoV-2 virus has necessitated the fast-tracked development of many research tools for understanding this virus’s pathogenesis, as well…
The regulations for food and drug in the United States, described in the Title 21 of the Code of Federal Regulations, and the EudraLex Annex 11 in EU, are critical in ensuring safe…
For over 40 years, Molecular Devices has been at the forefront of technological advances which have contributed to significant scientific breakthroughs. To kick off the new year, we…
Absorbance microplate readers are widely used in research, drug discovery, bioassay validation, quality control, and manufacturing processes in the pharmaceutical, biotech, food and…
With the recent rise in the prevalence of celiac disease, monitoring gluten levels in food and beverage has become increasingly important as more people strive to avoid gluten.
G-Protein Coupled Receptors (GPCRs) are important transmembrane proteins that translate extracellular signals into intracellular responses. These intracellular responses are comprised…
Research in the Leach Laboratory at the University of California Davis focuses on cellular and tissue engineering. Initial project development focuses on bone tissue engineering and…
The second messenger 3’, 5’ cyclic guanosine monophosphate (cGMP) and its associated proteins have been shown to be integral in regulating physiological responses such as smooth muscle…
Explore how the MultiWash+ Microplate Washer can improve lab efficiency with its small footprrint and flexibile washing modes.
ELISA Workflow Using the EMax plus Microplate Reader and MultiWash+ Microplate Washer
Latest Citations: For a complete list, please click here .
The Kroemer Lab is interested in the molecular mechanisms of cellular stress and death. The mode of cellular stress and death that is evoked during cancer treatment has profound therapeutic implications. A systematic search has been launched to identify molecular switches that “decide” which particular cell stress or cell death subroutine is preferentially executed. In addition, cancer cell death modalities and their impact on the immune system are analyzed in a systematic fashion to develop strategies that improve the chances of therapeutic success.
The Cell Biology platform (pictured, right) within the Kroemer Lab is used as a hub to conduct screening approaches as it offers fully automated cell biology workflows that allow for the phenotypic screening of large-scale compound and siRNA libraries. They use a battery of fluorescent biosensor cells to assess all types of cellular stress and death.
To enable this cutting-edge research, the group needed a high-content analysis system that they could fully integrate into an automated platform which also includes compound management and automated cell culture.
Ergonovine or ergonovinine was isolated from the aerial parts of endophyte (Neotyphodium gansuense) infected (E+) drunken horse grass (Achnatherum inebrians), neither of which existed in endophyte-free (E−) plants. Both of these ergot alkaloids had a cytotoxic effect on animal smooth muscle cells and increased cell growth inhibition with greater concentrations, in a significantly (P < 0.05) positive correlation. The median inhibitory concentrations (IC50) for ergonovine and ergonovinine were 71.95 and 72.75 μg/mL, respectively. These results indicate that endophytic ergot alkaloids may be the cause of drunken horse grass poisoning.
Menopause in women occurs at mid-life. Chimpanzees, in contrast, continue to display cycles of menstrual bleeding and genital swelling, suggestive of ovulation, until near their maximum life span of about 60 years. Because ovulation was not confirmed hormonally, however, the age at which chimpanzees experience menopause has remained uncertain. In the present study, we provide hormonal data from urine samples collected from 30 female chimpanzees, of which 9 were old (>30 years), including 2 above the age of 50 years. Eight old chimpanzees showed clear endocrine evidence of ovulation, as well as cycles of genital swelling that correlated closely with measured endocrine changes. Endocrine evidence thus confirms prior observations (cyclic anogenital swelling) that menopause is a late-life event in the chimpanzee. We also unexpectedly discovered an idiopathic anovulation in some young and middle-aged chimpanzees; this merits further study. Because our results on old chimpanzees validate the use of anogenital swelling as a surrogate index of ovulation, we were able to combine data on swelling and urinary hormones to provide the first estimates of age-specific rates of menopause in chimpanzees. We conclude that menopause occurs near 50 years of age in chimpanzees as it does in women. Our finding identifies a basic difference between the human and chimpanzee aging processes: female chimpanzees can remain reproductively viable for a greater proportion of their life span than women. Thus, while menopause marks the end of the chimpanzee’s life span, women may thrive for decades more.
|MultiWash+ for 96-well plates: 4 liquid lines, 8-way manifold and tubing, 4 wash/rinse bottles (2L), 1 waste bottle (2.5L)||MultiWash+|
|Optional 16-way manifold||5032338|
|Optional 12-way manifold)||5032336|
|Washer maintenance kit: 2 X T 2.5A spare fuses, 2 cleaning needles, tubing sets for all bottles, cleaning tool for needles, tubing set for manifold, and spare tubing set for manifold||5032339|
|External Tubing Kit (4-way)||5032340|
|Rinse bottle 2L||5032342|