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Efficient cell washing with minimal cell loss and optimal assay performance

The AquaMax® Microplate Washer is a fully self-contained system, configurable for both 96- and 384-well microplates. Use preconfigured wash, soak, and aspiration protocols or create your own multi-step protocol using the simple touchscreen interface. For biochemical assays, the washer removes unbound material and unreacted reagents. For cell-based assays, the washer has the option for 96- or 384-well cell wash heads with angled pins to allow extremely gentle washing of weakly adherent cell types.

  • Ease of use

    Install easily

    The washer does not require external pumps or a computer to operate, minimizing bench space. Interchangeable wash heads can be installed in seconds without tools, calibration, or alignment.

  • Accuracy

    Eliminate plate indexing

    Aspiration and dispensing of 96- and 384-wells occur simultaneously in all wells leading to high-precision assays and faster microplate processing without mechanical plate indexing or quadrant processing.

  • Efficiency

    Run multiple wash protocols

    Two- or four-fluid inlets with matching color-coded tubing facilitate quick assembly of the buffer and solution bottles and allow multiple wash protocols to be run without switching bottles.

AquaMax Microplate Washer

AquaMax Microplate Washer

Features

  • Trouble-free operation

    Comprehensive cleaning protocols can be activated at the touch of a button for trouble-free operation. A standby feature keeps the washer primed and probe tips submersed in buffer for instant startup.

  • Versatility

    Precise dispense and aspiration control allow processing without cell disruption. Fast sequential, continuous, and bottom washing options reduce wash times to a minimum.

  • Flexibility

    By using automatically-detected, interchangeable 96 and 384 wash heads, the AquaMax washer configures easily to meet current and future, higher-density microplate application requirements.

  • Automation

    The washer is easy to integrate with the latest automation tools. It is compatible with the Molecular Devices StakMax® Microplate Stacker and many robotic plate handlers.

Proven GxP solutions to assure data integrity and compliance

Our comprehensive suite of proven compliance solutions for GMP/GLP labs can advance your efforts to quickly and confidently establish a compliant laboratory.

  • Best-in-class microplate readers and washers support all your assay needs
  • IQ/OQ/PM services preserve instrument documentation in a digital and compliant format
  • Software installation services verify and document that required components are installed to operational specifications
  • Software validation service supports FDA 21 CFR Part 11 guidelines
  • Validation plates test the performance of your microplate reader using traceable materials for reliable results
GxP compliance solutions for GMP-GLP labs

 

Applications of AquaMax Microplate Washer

Specifications & Options of AquaMax Microplate Washer

Resources of AquaMax Microplate Washer

Presentations
Videos & Webinars
Antigen / Immunogen Discovery and Optimization

Immunology and Vaccine Development Workflow

AquaMax Microplate Washer

AquaMax Microplate Washer

  • Citation
    Dated: Dec 01, 2017
    Publication Name: Muscle Stem Cells

    Systematic Identification of Genes Regulating Muscle Stem Cell Self-Renewal and Differentiation

    The hallmark of stem cells is their capability to either self-renew or to differentiate into a different cell type. Adult skeletal muscle contains a resident muscle stem cell population (MuSCs) known as satellite cells, which enables regeneration of damaged muscle tissue throughout most of adult life. During skeletal muscle regeneration, few MuSCs… View more

    The hallmark of stem cells is their capability to either self-renew or to differentiate into a different cell type. Adult skeletal muscle contains a resident muscle stem cell population (MuSCs) known as satellite cells, which enables regeneration of damaged muscle tissue throughout most of adult life. During skeletal muscle regeneration, few MuSCs self-renew to maintain the muscle stem cell pool while others expand rapidly and subsequently undergo myogenic differentiation to form new myofibers. However, like for other stem cell types, the molecular networks that govern self-renewal and/or differentiation of MuSCs remain largely elusive. We recently reported a method to isolate sufficient amounts of purified MuSCs from skeletal muscle which enables us to study their cell autonomous properties. Here, we describe a lentiviral, image-based loss-of function screening pipeline on primary MuSCs that enables systematic identification of genes that regulate muscle stem cell function.

    Contributors: Krishnamoorthy Sreenivasan, Thomas Braun, Johnny Kim  
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  • Citation
    Dated: Feb 15, 2017
    Publication Name: Nature

    Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

    A highly protective malaria vaccine would greatly facilitate the prevention and elimination of malaria and containment of drug-resistant parasites1. A high level (more than 90%) of protection against malaria in humans has previously been achieved only by immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (PfSPZ)… View more

    A highly protective malaria vaccine would greatly facilitate the prevention and elimination of malaria and containment of drug-resistant parasites1. A high level (more than 90%) of protection against malaria in humans has previously been achieved only by immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (PfSPZ) inoculated by mosquitoes2,3,4; by intravenous injection of aseptic, purified, radiation-attenuated, cryopreserved PfSPZ (‘PfSPZ Vaccine’)5,6; or by infectious PfSPZ inoculated by mosquitoes to volunteers taking chloroquine7,8,9,10 or mefloquine11 (chemoprophylaxis with sporozoites). We assessed immunization by direct venous inoculation of aseptic, purified, cryopreserved, non-irradiated PfSPZ (‘PfSPZ Challenge’12,13) to malaria-naive, healthy adult volunteers taking chloroquine for antimalarial chemoprophylaxis (vaccine approach denoted as PfSPZ-CVac)14. Three doses of 5.12 × 104 PfSPZ of PfSPZ Challenge12,13 at 28-day intervals were well tolerated and safe, and prevented infection in 9 out of 9 (100%) volunteers who underwent controlled human malaria infection ten weeks after the last dose (group III). Protective efficacy was dependent on dose and regimen. Immunization with 3.2 × 103 (group I) or 1.28 × 104 (group II) PfSPZ protected 3 out of 9 (33%) or 6 out of 9 (67%) volunteers, respectively. Three doses of 5.12 × 104 PfSPZ at five-day intervals protected 5 out of 8 (63%) volunteers. The frequency of Pf-specific polyfunctional CD4 memory T cells was associated with protection. On a 7,455 peptide Pf proteome array, immune sera from at least 5 out of 9 group III vaccinees recognized each of 22 proteins. PfSPZ-CVac is a highly efficacious vaccine candidate; when we are able to optimize the immunization regimen (dose, interval between doses, and drug partner), this vaccine could be used for combination mass drug administration and a mass vaccination program approach to eliminate malaria from geographically defined areas.

    Contributors: Benjamin Mordmüller, Güzin Surat, Heimo Lagler, Sumana Chakravarty, Andrew S. Ishizuka, Albert Lalremruata, Markus Gmeiner, Joseph J. Campo, Meral Esen, Adam J. Ruben, Jana Held, Carlos Lamsfus Calle, Juliana B. Mengue, Tamirat Gebru, Javier Ibáñez, Mihály Sulyok, Eric R. James, Peter F. Billingsley, KC Natasha, Anita Manoj, Tooba Murshedkar, Anusha Gunasekera, Abraham G. Eappen, Tao Li, Richard E. Stafford, Minglin Li, Phil L. Felgner, Robert A. Seder, Thomas L. Richie, B. Kim Lee Sim, Stephen L. Hoffman & Peter G. Kremsner -Show fewer authors  
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  • Citation
    Dated: Nov 01, 2014
    Publication Name: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

    Evaluation of yolk protein levels as estrogenic biomarker in bivalves; comparison of the alkali-labile phosphate method (ALP) and a species-specific immunoassay (ELISA)

    Altered concentration of the vertebrate yolk protein precursor vitellogenin is a recognized biomarker for endocrine disruption in fish, and within recent years yolk protein alteration has also been associated with endocrine disruption in bivalves. Species-specific, direct and sensitive methods for quantification of vitellogenin in fish have been… View more

    Altered concentration of the vertebrate yolk protein precursor vitellogenin is a recognized biomarker for endocrine disruption in fish, and within recent years yolk protein alteration has also been associated with endocrine disruption in bivalves. Species-specific, direct and sensitive methods for quantification of vitellogenin in fish have been available for years whereas bivalve yolk protein levels have been estimated indirectly by alkali-labile phosphate (ALP) liberated from high molecular weight proteins because the sequence and biochemical structure of most bivalve yolk proteins are unknown. By applying a species-specific enzyme-linked immunosorbent assay (ELISA) for accurate determination of yolk protein level the impact of 17β-estradiol (57, 164 and 512 ng/L) on the freshwater bivalve Unio tumidus was investigated and compared with ALP estimations. Seven weeks of exposure during the pre-spawning and spawning period had no consistent effect on yolk protein concentration in hemolymph, and ALP levels in hemolymph also remained unchanged in both males and females. Further, basal male and female ALP levels were indistinguishable whereas the ELISA demonstrated that yolk protein levels of females exceeded male levels at the time of sampling, although male basal levels were high compared to fish. Altogether it is shown that individual ALP levels do not reflect yolk protein levels and hence hemolymph ALP levels cannot serve as biomarker for estrogenic exposure during the pre-spawning and spawning period in U. tumidus. The necessity of sensitive and validated biomarkers for reliable interpretation of data and the utility of ALP and yolk protein levels as biomarkers in bivalves are discussed.

    Contributors: Jane E. Morthorst, Henrik Holbech, Morten Jeppesen, Karin L. Kinnberg, Knud L. Pedersen, Poul Bjerregaard  
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AquaMax® Microplate Washer

Product

Part  Number

AquaMax 2K Bundle includes AquaMax 2000 Microplate Washer, 96-Plate Wash Head, Two Assay Bottles with level sensor, and 10L Waste bottle with sensor
AQUAMAX 2K
AquaMax 4K Bundle includes AquaMax 4000 Microplate Washer, 96-Plate Wash Head, Four Assay Bottles with level sensor, and 10L Waste bottle with sensor AQUAMAX 4K
StakMax Microplate Handling Stacker
STAKMAX
AquaMax Sterilant
R8156
On-site Compliance Assurance IQOQ Service for AquaMax 2000 Plate Washers (Installation Qualification/Operation Qualification service including detailed IQOQ results for system owner qualification records)
AQ2000-IQOQSVC-OS
On-site Compliance Assurance IQOQ Service for AquaMax 4000 Plate Washers (Installation Qualification/Operation Qualification service including detailed IQOQ results for system owner qualification records)
AQ4000-IQOQSVC-OS

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