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Preconfigured protocols and custom assay workflows simplify microplate data acquisition and analysis

SoftMax® Pro Software for Windows 10 is designed to provide the simplicity, flexibility and power required for advanced data analysis. It provides ready-to-run protocols, analysis algorithms, and 21 different curve fit options. Every step is optimized for data acquired from a Molecular Devices microplate reader or data imported from another source to simplify analysis and reporting. Compliance tools are available for regulated laboratories providing end-to-end chain of custody.

  • Simplify data measurement Icon

    Simplify data measurement

    The software offers a variety of options to initiate the measurement of a microplate assay through prewritten protocols with included acquisition settings or by setting custom experiment parameters.

  • Import and analyze complex data Icon

    Import and analyze complex data

    Import raw data in microplate format acquired from any scientific instrument, consolidate data reduction from diverse data sources, and reduce errors with consistent data evaluation methods.

  • Publish like a pro Icon

    Publish like a pro

    The software includes tools to publish reports with flexible data output formats. Data can be viewed in a lab notebook layout, saved as a PDF file, exported to an Excel file or to XML for LIMS integration.

SoftMax Pro 7 Software

SoftMax Pro 7 Software

Features

  • Built-in protocols Icon

    Built-in protocols

    Use over 160 protocols with preconfigured assay parameters for a wide variety of common assays including protocols for our entire suite of reagents, SpectraTest® Validation Plates, and adapter plates.

  • Advanced reader control Icon

    Advanced reader control

    Build custom assay workflow, run multitask kinetics, and pause and resume kinetic reads with the discontinuous kinetics feature.

  • Flexible calculations Icon

    Flexible calculations

    Data analysis features are available such as 21 different curve fit options, simplified cross-plate analysis and interpolation, and automatic calculations of relative potency, EC50, and Z factors.

  • Project management made easy Icon

    Project management made easy

    Group multiple plate reads in one protocol. Display results, conditional pass/fail statements, mini graphs, and images in the notes section for easy viewing of overall project results.

  • Secure electronic record keeping Icon

    Secure electronic record keeping

    Controlled user access is provided through a granular permission structure and unique logins with electronic signature support for verification, authorization, and approval, including audit trails.

  • Validation tools reduce cost Icon

    Validation tools reduce cost

    Extensive suite of microplate reader validation tools can reduce the cost and time of validation by 50% when compared to using multiple platforms to collect and analyze data.

Proven GxP solutions to assure data integrity and compliance

Our comprehensive suite of proven compliance solutions for GMP/GLP labs can advance your efforts to quickly and confidently establish a compliant laboratory.

  • Best-in-class microplate readers and washers support all your assay needs
  • IQ/OQ/PM services preserve instrument documentation in a digital and compliant format
  • Software installation services verify and document that required components are installed to operational specifications
  • Software validation service supports FDA 21 CFR Part 11 guidelines
  • Validation plates test the performance of your microplate reader using traceable materials for reliable results
GxP compliance solutions for GMP-GLP labs

 

Applications of SoftMax Pro Software

Specifications & Options of SoftMax Pro Software

 

Helpful Tips:

  • To prevent data loss, turn off all sleep and hibernation settings for the hard disk, the CPU, and the USB ports
  • Disable automatic Windows Updates
  • Update WIndows manually when the instrument isn't being used by the software; these options can be enabled in Windows Control Panel

Note: Installing and using the SoftMax Pro Software on the Windows XP operating system is no longer supported. The software is neither tested nor validated on Windows XP.

Resources of SoftMax Pro Software

Presentations
Videos & Webinars
Week 5 Video Thumbnail

Urban myths of microplate readers: Read-Copy-Paste-Analyze. Repeat... Sound familiar?

Week 4 Video Thumbnail

Urban myths of microplate readers: Beyond the basics - real time, resolving time and transferring energy

Week 3 Video Thumbnail

Urban myths of microplate readers: “Optimization? But the manual says I need to be excited at 490nm!"

 Week 1 Video Thumbnail

Urban myths of microplate readers: OD, RFU or RLU - What exactly are they and why bigger is not always better!

Week 2 Video thumbnail

Urban myths of microplate readers: Which microplate reader? Decisions, decisions and how to be less confused!

SoftMax Pro 7 Software

Using the export function in SoftMax Pro 7 Software

SoftMax Pro 6.4.1 Import Feature

SoftMax Pro 6.4.1 Import Feature

SoftMax Pro 6.5 Acquisition View

SoftMax Pro 6.5 Acquisition View

Multitask Kinetics Workflow with the SoftMax Pro 7 Workflow Editor

Creating a Multitask Kinetics Workflow with the SoftMax Pro 7 Workflow Editor

SoftMax Pro 7 Software

SoftMax Pro 7 Software

Creating New Graph in Softmax Pro 7 Software

Creating a New Graph in SoftMax Pro 7 Software

Modifying Existing Graphs in SoftMax Pro 7

Modifying Existing Graphs in SoftMax Pro 7 Software

Setting up a Plate Template in SoftMax Pro 7

Setting up a Plate Template in SoftMax Pro 7 Software

Autosave Option in SoftMax Pro 7

Using the Autosave Option in SoftMax Pro 7 Software

Absorbance Assay in SoftMax Pro 7 Software

Setting up an Absorbance Assay in SoftMax Pro 7 Software

Curve Fitting Features and PLA

Curve Fitting Features and PLA: A Practical Guide for SoftMax Pro 6

SoftMax Pro 6 Software

SoftMax Pro 6 Software

Microplate Data Acquisition and Data Analysis Using SoftMax Pro 6 Software

How to Do Microplate Data Acquisition and Data Analysis Using SoftMax Pro 6 Software

Getting Started with SoftMax Pro 6 Software

Getting Started with SoftMax Pro 6 Software

SoftMax Pro 6 Data Acquisition Tips and Tricks

SoftMax Pro 6 Data Acquisition Tips and Tricks

SoftMax Pro 6 Data Acquisition Tips and Tricks (French)

SoftMax Pro 6 Data Acquisition Tips and Tricks (French)

SoftMax Pro 6 Data Acquisition Tips and Tricks (German)

SoftMax Pro 6 Data Acquisition Tips and Tricks (German)

SoftMax Pro 6.2 GxP: Compliance Without Complications

SoftMax Pro 6.2 GxP: Compliance Without Complications

Setting up a Plate Template with Dilution in SoftMax Pro 7 Software

Setting up a Plate Template with Dilution in SoftMax Pro 7 Software

  • Citation
    Dated: Apr 23, 2021
    Publication Name: Nature Protocols

    Quantification of SARS-CoV-2 neutralizing antibody by wild-type plaque reduction neutralization, microneutralization and pseudotyped virus neutralization assays

    Virus neutralization assays measure neutralizing antibodies in serum and plasma, and the plaque reduction neutralization test (PRNT) is considered the gold standard for measuring levels of these antibodies for many viral diseases. We have developed procedures for the standard PRNT, microneutralization assay (MNA) and pseudotyped virus… View more

    Virus neutralization assays measure neutralizing antibodies in serum and plasma, and the plaque reduction neutralization test (PRNT) is considered the gold standard for measuring levels of these antibodies for many viral diseases. We have developed procedures for the standard PRNT, microneutralization assay (MNA) and pseudotyped virus neutralization assay (PNA) for severe acute respiratory syndrome coronavirus 2. The MNA offers advantages over the PRNT by reducing assay time, allowing increased throughput and reducing operator workload while remaining dependent upon the use of wild-type virus. This ensures that all severe acute respiratory syndrome coronavirus 2 antigens are present, but Biosafety Level 3 facilities are required. In addition to the advantages of MNA, PNA can be performed with lower biocontainment (Biosafety Level 2 facilities) and allows for further increases in throughput. For each new vaccine, it is critical to ensure good correlation of the neutralizing activity measured using PNA against the PRNT or MNA. These assays have been used in the development and licensure of the ChAdOx1 nCoV-19 (AstraZeneca; Oxford University) and Ad26.COV2.S (Janssen) coronavirus disease 2019 vaccines and are critical for demonstrating bioequivalence of future vaccines.

    Contributors: Kevin R. Bewley, Naomi S. Coombes, Luc Gagnon, Lorna McInroy, Natalie Baker, Imam Shaik, Julien R. St-Jean, Natalie St-Amant, Karen R. Buttigieg, Holly E. Humphries, Kerry J. Godwin, Emily Brunt, Lauren Allen, Stephanie Leung, Phillip J. Brown, Elizabeth J. Penn, Kelly Thomas, Greg Kulnis, Bassam Hallis, Miles Carroll, Simon Funnell & Sue Charlton  
    Go to article

  • Citation
    Dated: Dec 15, 2020
    Publication Name: Vaccine

    Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines

    Enzyme linked immunosorbent assay (ELISA) has been widely used to measure antibody titers for evaluating the immunogenicity of a vaccine. However, there is as yet no generally accepted way of expressing the ELISA results in the case of experimental vaccines, since there is usually no uniform standard. Both end point and single dilution methods… View more

    Enzyme linked immunosorbent assay (ELISA) has been widely used to measure antibody titers for evaluating the immunogenicity of a vaccine. However, there is as yet no generally accepted way of expressing the ELISA results in the case of experimental vaccines, since there is usually no uniform standard. Both end point and single dilution methods have significant disadvantages. In this paper, we obtained reproducible data with fewer dilutions of samples by addition of serially diluted standard serum to each ELISA plate. Since this ELISA method gives reliable antibody titer with less labor than other methods, it can strongly support vaccine development.

    Contributors: Kazutoyo Miura, Andrew C. Orcutt, Olga V.Muratova, Louis H.Miller Allan, Saul, Carole A. Long  
    Go to article

  • Citation
    Dated: Aug 17, 2020
    Publication Name: Springer

    Drug Removal Strategies in Competitive Ligand Binding Neutralizing Antibody (NAb) Assays: Highly Drug-Tolerant Methods and Interpreting Immunogenicity Data

    Neutralizing anti-drug antibody (NAb) assays often have lower drug tolerance (DT) than trough drug concentrations, potentially under-estimating NAb incidence. To improve DT, drug-specific proteins were coupled to magnetic beads to deplete drug in the sample. View more

    Neutralizing anti-drug antibody (NAb) assays often have lower drug tolerance (DT) than trough drug concentrations, potentially under-estimating NAb incidence. To improve DT, drug-specific proteins were coupled to magnetic beads to deplete drug in the sample.

    Contributors: Michael A. Partridge, Elif Kabuloglu Karayusuf, Gary Shyu, Camille Georgaros, Albert Torri & Giane Sumner  
    Go to article

  • Citation
    Dated: Mar 03, 2020
    Publication Name: International Immunopharmacology

    Parallel comparison of three methodologies for measuring functional C1-inhibitor in Hereditary angioedema patients

    Hereditary angioedema (HAE) types I and II are characterized by functional C1 inhibitor (fC1-INH) deficiency which results in bradykinin overproduction. Sensitive, specific and robust methods to quantitate fC1-INH in human samples are required for diagnosing HAE and/or to measure pharmacodynamic activity of C1-INH drugs in clinical studies. View more

    Hereditary angioedema (HAE) types I and II are characterized by functional C1 inhibitor (fC1-INH) deficiency which results in bradykinin overproduction. Sensitive, specific and robust methods to quantitate fC1-INH in human samples are required for diagnosing HAE and/or to measure pharmacodynamic activity of C1-INH drugs in clinical studies.

    Contributors: Archana Kapoor, Brijesh K. Garg, Zhiwei Zhou, Peng Lu, Priya S.Chockalingam  
    Go to article

  • Citation
    Dated: Jun 17, 2019
    Publication Name: Nature

    Mitotically heritable effects of BMAA on striatal neural stem cell proliferation and differentiation

    The widespread environmental contaminant β-methylamino-L-alanine (BMAA) is a developmental neurotoxicant that can induce long-term learning and memory deficits. Studies have shown high transplacental transfer of 3H-BMAA and a significant uptake in fetal brain. View more

    The widespread environmental contaminant β-methylamino-L-alanine (BMAA) is a developmental neurotoxicant that can induce long-term learning and memory deficits. Studies have shown high transplacental transfer of 3H-BMAA and a significant uptake in fetal brain.

    Contributors: Paula Pierozan & Oskar Karlsson  
    Go to article

  • Citation
    Dated: Oct 01, 2018
    Publication Name: Crop Protection

    Identification and characterization of abamectin resistance in Tetranychus urticae Koch populations from greenhouses in Turkey

    The two-spotted spider mite, Tetranychus urticae Koch is one of the most serious pests in greenhouses and has developed high resistance to many classes of acaricides rapidly. Three T. urticae populations were collected from vegetable greenhouses in Antalya and Muğla, Turkey. These populations showed high resistance levels to abamectin ranging… View more

    The two-spotted spider mite, Tetranychus urticae Koch is one of the most serious pests in greenhouses and has developed high resistance to many classes of acaricides rapidly. Three T. urticae populations were collected from vegetable greenhouses in Antalya and Muğla, Turkey. These populations showed high resistance levels to abamectin ranging between 223 and 404 fold compared to a susceptible population. The interaction of some synergists (piperonyl butoxide; PBO, diethyl maleate; DEM and S-benzyl O,O-diisopropyl phosphorothioate; IBP) with abamectin was analyzed showing possible implication of esterases in resistances in the three populations studied. The activities of esterase, glutathione S-transferase (GST) and cytochrome P450 (p450) was determined using α-naphthyl acetate, 1-chloro-2,4 dinitrobenzene (CDNB) and 7-ethoxycoumarin (7-EC) as substrates, respectively. In all field populations, esterase, glutathione S-transferase and P450 activities were higher, when compared to the susceptible population (GSS). The presence of known abamectin resistance target site mutations (G314D and G326E) on the glutamate gated chloride channels was also examined. However, no target site–resistance mutation was detected in all three populations. According to our results, detoxification enzymes, but no target site intensivity seem to play role in abamectin resistance in field T. urticae populations from Turkey.

    Contributors: Naciye Sena Çağatay, Pauline Menault, Maria Riga, John Vontas, Recep Ay  
    Go to article

  • Citation
    Dated: Apr 04, 2001
    Publication Name: Journal of Investigative Dermatology

    An Alternative Approach to Depigmentation by Soybean Extracts via Inhibition of the PAR-2 Pathway

    The protease-activated receptor 2, expressed on keratinocytes but not on melanocytes, has been ascribed functional importance in the regulation of pigmentation by phagocytosis of melanosomes. Inhibition of protease-activated receptor 2 activation by synthetic serine protease inhibitors requires keratinocyte-melanocyte contact and results in… View more

    The protease-activated receptor 2, expressed on keratinocytes but not on melanocytes, has been ascribed functional importance in the regulation of pigmentation by phagocytosis of melanosomes. Inhibition of protease-activated receptor 2 activation by synthetic serine protease inhibitors requires keratinocyte-melanocyte contact and results in depigmentation of the dark skinned Yucatan swine, suggesting a new class of depigmenting mechanism and agents. We therefore examined natural agents that could exert their effect via the protease-activated receptor 2 pathway. Here we show that soymilk and the soybean-derived serine protease inhibitors soybean trypsin inhibitor and Bowman-Birk inhibitor inhibit protease-activated receptor 2 cleavage, affect cytoskeletal and cell surface organization, and reduce keratinocyte phagocytosis. The depigmenting activity of these agents and their capability to prevent ultraviolet-induced pigmentation are demonstrated both in vitro and in vivo. These results imply that inhibition of the protease-activated receptor 2 pathway by soymilk may be used as a natural alternative to skin lightening.

    Contributors: Christine Paine, Elizabeth Sharlow, Frank Liebel, Magdalena Eisinger, StanleyShapiro, MiriSeiberg  
    Go to article

SoftMax Pro 7 Software

Product

Annual Subscription License

Non-Expiring License

SoftMax Pro Standard Software

Windows 10 compatible

One year subscription to the latest version of SoftMax Pro 7. Includes one activation key, which expires after one year.  Annual renewal.

Part number: 
SMP7 PROF SUBSCR

 

Special pricing for verified academic institutions.  
To take advantage of our academic discount for SoftMax Pro, please contact your local sales representative or call 1 (877) 589-2214 to place your order.

For contact numbers outside the US, please visit our contact page.

Non-expiring license for the latest version of SoftMax Pro 7. Includes four activation keys.

Part number:
SMP7 PROF 

 

Special pricing for verified academic institutions.  
To take advantage of our academic discount for SoftMax Pro, please contact your local sales representative or call 1 (877) 589-2214 to place your order.

For contact numbers outside the US, please visit our contact page.

SoftMax Pro Importer XLS

Requires SoftMax Pro 6.4.1 or higher

One year subscription to enable import of data into SoftMax Pro from Excel based template.

Includes one activation key, which expires after one year.  Annual renewal.

Part number: (Click below to purchase/download)
SMP.IMPORT.XLS

 

SoftMax Pro Importer XLS and XML

Requires SoftMax Pro 6.4.1 or higher

One year subscription to enable import of data into SoftMax Pro from Excel based template or XML file.

Includes one activation key, which expires after one year.  Annual renewal.

Part number: (Click below to purchase/download)
SMP.IMPORT.XLS.AND.XML

Non-expiring license to enable import of data into SoftMax Pro from Excel-based template or XML file.

Includes one activation key for one computer.

Part number: (Click below to purchase/download) SMP.IMPORT.XLS.AND.XML.NONEXP
 

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