Label-free imaging solution for assurance of monoclonality
The CloneSelect™ Imager is a high-throughput automated solution for imaging and analyzing mammalian cells. Tracking the formation of a colony from a single cell is effortless as barcoded plates are tracked over time. Automated acquisition and analysis provide accurate, objective, and consistent results. Detailed imaging and comprehensive data analysis enable better decision making. With the ability to image a 96-well plate in 90 seconds, the imager will increase throughput and productivity.
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Verify monoclonality easily
The Monoclonality Report feature streamlines the creation of supporting documentation for regulatory agencies. Reports are automatically generated based on parameters you select.
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Detect cells accurately
Algorithms are optimized for accurate cell detection and address varying cell types and conditions. High resolution imaging provides accuracy and assurance of monoclonality.
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Screen more clones in less time
The imager delivers industry leading acquisition times, allowing for imaging a 96-well plate in as little at 90 seconds.
Features
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Product Brochure
CloneSelect™ Imager
CloneSelect Imager system produces objective, quantitative, and consistent results in less time to overcome the challenges associated with conventi…
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Product Brochure
CloneSelect Imager Monoclonality Report Feature
Providing image evidence of monoclonality in the cell line development process is not as simple as exporting an image of a single cell. For example…
Applications of CloneSelect Imager
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Cell Line Development
Cell line development is a critical step in the process of generating biopharmaceutical molecules, such as monoclonal antibodies. The process often begins with transfecting the host cell type with the DNA encoding the therapeutic protein of interest allowing for random or directed integration of target DNA into the host cell genome. Thousands of clones are screened to isolate the rare high producing cells, a manual and time-consuming process.
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Cell Viability
Cell line development requires the discovery of single cell-derived clones that produce high and consistent levels of the target therapeutic protein. A critical first step in the process is the isolation of single, viable cells. Single-cells proliferate to form colonies, that can then be assessed for productivity of the target therapeutic protein. Viability and growth rates of single cell-derived clones can be characterized on the CloneSelect Imager.
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Monoclonality Assurance
Cell line development and assurance of monoclonality are critical steps in the process of generating biopharmaceutical molecules, such as monoclonal antibodies. A cell line can be established following the isolation of a single viable cell robustly expressing the protein of interest. A key milestone in this process is documenting evidence of clonality. Documentation of clonality is typically image-based, whereby an image of a single cell is produced and included in regulatory filings.
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Label-Free Cell Migration
Wound healing assays are used in a range of disciplines to study cell migration, the coordinated movement of a cell population. A manual or standardized wound is generated on a monolayer of cells grown in microplates. The microplates can be screened against a library to study the effect on cell migration. The effect of a library of compounds or genes can be studied using this approach. The CloneSelect Imager enables the rapid imaging (<90 s per plate) and objective, automated analysis of cell migration.
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Colony Forming Assay
The soft agar colony formation assay is a classical and renowned technique for characterizing the ability of cells to undergo anchorage-independent growth, a hallmark of carcinogenesis. After seeding in a matrix that enhances colony formation, such as a semi-solid media, cells are typically incubated with compounds that may affect colony growth. The CloneSelect Imager can image every well and automatically calculate confluence, estimate colony number and area, and track colony growth.
Specifications & Options of CloneSelect Imager
* Price, time to deliver and specifications will vary based on mutually agreed technical requirements. Solution requirements may cause adjustment to standard performance.
Resources of CloneSelect Imager
Product Brochure
CloneSelect™ Imager
CloneSelect Imager system produces objective, quantitative, and consistent results in less time to overcome the challenges associated with conventi…
Product Brochure
CloneSelect Imager Monoclonality Report Feature
Providing image evidence of monoclonality in the cell line development process is not as simple as exporting an image of a single cell. For example…
Product Brochure
Accelerate Cell Line Development
Explore PDF to learn how you can accelerate your cell line development and get to your high value hits faster.
Application Note
Improved productivity of cell line development using fully integrated…
Cell line development requires screening tens of thousands of clones in order to find the few clones that are stable, grow well, and produce high…
Application Note
Confident assurance of clonality using calcein AM with minimal effect…
The development of cell lines that express a specified protein of interest is critical to the generation of biopharmaceutical molecules such as…
Application Note
Objective quantification of cell migration on the CloneSelect Imager…
Cell migration is a key process in normal development, immune function and wound healing. Abnormal cell migration is a feature of conditions such as…
Application Note
Confluence and growth curve generation on the CloneSelect Imager
The ability to monitor cell proliferation has become increasingly important, particularly with the widespread use of in vitro cell lines as model…
Application Note
Enhanced development of virus-specific hybridomas using ClonePix and…
The ClonePix System was employed in the high-throughput screening of hundreds of sub-cloned colonies from parental hybridoma material (historically…
Data Sheet
Ensure Ongoing Compliance for Your CloneSelect™ Imager
Qualifying your Molecular Devices CloneSelect Imager in GLP or GMP environments can now be done with greater reliability, security, and convenience…
eBook
Select High-Value Cell Lines Like a Pro
Accelerate cell line development for recombinant proteins and monoclonal
antibody productionScientific Poster
Accelerated one-step screening and selection of PER.C6® clones using…
In this poster, we present data demonstrating that CloneMedia-PER.C6 supports the growth of cells into discrete colonies that can be imaged, ranked…
Scientific Poster
Rapid High-Throughput Screening and Selection for Clonal Populations…
This PDF file explores ClonePix FL Technology which is based on the culture of mammalian cell lines in semisolid media originating from one single…
Scientific Poster
High Throughput Screening and Selection of Clonal Populations of…
Advances in cell culture techniques are facilitating development of novel screening assays which enable drug discovery programmes to rely on cell-b…
Scientific Poster
An Optimized Media Solution for Antibody Production in Hybridomas
Get an overview of the complete solution for high-throughput hybridoma cloning and screening for antibody discovery provided by Molecular Devices.…
Scientific Poster
Screening and Isolation of Antigen Specific IgG-Secreting Hybridoma…
The pharmaceutical industry is under pressure to reduce development time for new therapeutic proteins in a cost-effective manner.
Scientific Poster
Bypassing the Need for High Throughput Processing in Cell Line…
Animal cell culture technology has been thrust to the forefront of the biopharmaceutical industry because of the superior fidelity of mammalian cel…
Scientific Poster
Rapid Selective in Situ Screening of Hybridomas in Semi-Solid Medium
Explore a simple one-step hybridoma selective secretion assay for detecting and isolating antigen-specific, IgG-secreting hybridoma clones in as li…
Scientific Poster
Integration of Automated Colony Picking into Fast Track Cell Line…
Download this PDF to learn about fast track cell Line development process with integrated automated colony picker.
Scientific Poster
Rapid Development of a Serum-Free, Suspension-Adapted CHO Cell…
Download PDF to explore the process for developing serum-free CHO cell line.
Scientific Poster
Imaging, Screening and Automated Selection of Mouse Embryonic Stem…
Explore non-invasive method for mouse Embrionic Stem Cell culture colony number & growth rate monitoring and identification using specific prob…
Scientific Poster
Non-Invasive, Label-Free Analysis of Cell Migration using CloneSelect…
Explore CloneSelect Imager’s Migration that provides a simple, but quantitative & accurate measure of cell migration based on objective, sensit…
Scientific Poster
Rapid Monoclonality Verification Methods to Boost Cell Line…
Here we present a fluorescent method for identifying monoclonal CHO-S cells using CellTracker Green CMDFA.
Presentations
Developing High Throughput Mammalian Expression Platforms
Download PDF and explore more about high throughput mammalian expression platforms & challenges with mammalian systems.
Videos

CloneSelect Imager

Identification and Selection of GPCR Cell Lines with ClonePix 2
Related Products & Services of CloneSelect Imager
Featured Applications

Cell Line Development
Cell line development is a critical step in the process of generating biopharmaceutical molecules,…
Read More
Cell Viability
Cell line development requires the discovery of single cell-derived clones that produce high and…
Read More
Colony Forming Assay
The soft agar colony formation assay is a classical and renowned technique for characterizing the…
Read More
Label-Free Cell Migration
Wound healing assays are used in a range of disciplines to study cell migration, the coordinated…
Read More
Monoclonality Assurance
Cell line development and assurance of monoclonality are critical steps in the process of…
Read MoreReady to get started?
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