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IN Carta Image Analysis Software

Provides robust, quantitative results from complex biological images and datasets
Go from assay to insights quickly and reliably with ImageXpress imaging systems and IN Carta software
IN Carta® Image Analysis Software solves complex image analysis problems utilizing advanced Artificial Intelligence (AI) transforming images into results, which can be interpreted with ease. User-friendly workflows help you get answers faster from 2D, 3D, and 4D experiments. With the integration of our Custom Module Editor application, you can define highly customized image analysis protocols allowing you to obtain robust results—even for complex assays—then quickly visualize, review, and interact with the analysis results. Let IN Carta software do the heavy lifting so you can focus on your research.
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Powerful
Guided workflows and scalable batch processing increase productivity and reduce time to answer. Experiments can be set up quickly and analysis of multiple wells is run in parallel.
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Insightful
Machine learning helps you leverage more information and increase accuracy in the analysis of high-content screening data to enable new discoveries with confidence.
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Intuitive
Modern user experience and cutting-edge technology minimizes the software learning curve and removes barriers to productivity.

IN Carta Image Analysis Software
Features
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Deep learning
Improve specificity of your image analysis workflows by utilizing the SINAP module. SINAP relies on deep learning-based image analysis, resulting in robust segmentation for virtually any biological structure.
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Focused worklists
Browse to a parent directory and populate your worklist with image datasets of interest or use search to locate a dataset of interest.
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AI-powered data analytics
Leverage the power of machine learning without being a data scientist. Identify and quantify phenotypic changes in a user-friendly workflow. Explore your data and reveal insights from complex datasets. Find novel and unexpected phenotypes with a few mouse clicks.
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Customization
Browse and review images from experiments, create image analysis protocols of different complexity and add on-demand data classification. Visualize analysis results using 360 ̊ data linking among images, data table and charts.
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3D analysis
The Custom Module Editor’s 3D application provides unprecedented flexibility in segmenting complex biological structures. Image datasets can be acquired in 3D or 4D (timelapse 3D) and tailored image analysis routines can be developed within a guided workflow.
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Batch analysis and monitoring
Analyze multiple experiments in batch analysis mode with one or more analysis protocols. Monitor the status of all submitted tasks and oversee their progression in real time.
IN Carta SINAP
SINAP is a module that uses deep learning algorithms to improve accuracy and reliability of high-content screening assays at the first step in the analysis pipeline—segmentation. It provides better object detection than traditional image analysis methods. Deep learning models can be easily tailored within a user-friendly tool, so that any novel biological objects can be segmented efficiently. Quantitative information extracted from segmented objects is more accurate, so errors are not propagated down the analysis pipeline.
With SINAP, Segmentation Is Not A Problem!
- Accurate – deep learning can maintain accuracy across difficult to segment samples including confluent cells, low signal-to-noise samples and transmitted light images
- Reliable – SINAP models can account for high phenotypic variability
- Flexible – a single workflow can deal with a variety of applications and imaging modalities
- Accessible – trained model learns to segment from scientist’s drawing on the image rather than asking a deep-learning guru to create a new model and optimize multiple parameters

Customized SINAP deep-learning models segment specific regions (whole body, head, eyes, brain) of a zebrafish embryo in transmitted light image. Courtesy of Guo Lab, UCSF
IN Carta Phenoglyphs
IN Carta® Phenoglyphs™ Software Module uses a unique combination of unsupervised and supervised machine learning to quantify phenotypical changes. Using many hundreds of cellular features that can be analyzed simultaneously, a comprehensive phenotypic profile is created and can be applied throughout an entire screening workflow. This multivariate approach to classification provides accurate characterization of object populations allowing users to resolve subtle phenotypic changes induced by drug treatment or genetic modification. It can be utilized across many biological targets including organoids, cells, spheroids, and more.

Classification of spheroids formed from HCT116 cells. Spheroids were stained with Hoechst 33342 to visualize nuclei. 3D stacks were collected over time.
- Comprehensive – a data driven approach that starts with an unsupervised clustering to find patterns in the data and highlight subpopulations without prior knowledge of what phenotypes may exist.
- Robust – dedicated machine learning algorithm identifies the optimal set of descriptive features to avoid overfitting of the resulting classification model.
- Optimized workflow – classification is achieved by simply confirming or correcting the algorithm’s predictions until it learns the right behavior.
IN Carta Custom Module Editor 2D and 3D
- Create simple step-by-step custom analysis
- Tailor object segmentation and classification
- Find objects localized within defined biological compartments
- Report only measurements required for an assay of interest
- Analyze live imaging data
- True 3D segmentation (3D application only)
- Robust reconstruction of 2D segmentation into volume for 3D assays (3D application only)
Example segmentation of iPSC-derived hepatocyte spheroids in Custom Module Editor
ImageXpress® Confocal HT.ai High-Content Imaging System
Powerful multi-laser light sources, a deep tissue penetrating confocal disk module, water immersion objectives and modern machine learning analysis software
- Ideal for highly complex cell-based and 3D assays
- Seven-channel high-intensity lasers generating brighter images with higher signal-to-background ratio
- Spinning confocal disk technology for deeper tissue penetration, resulting in sharper images with improved resolution
- Water immersion objectives offering up to quadruple the signal at lower exposure times for greater sensitivity and image clarity
- View product
StratoMineR Advanced Cloud-Based Analytics
Generate clear, deep data from complex datasets
Powerful and intuitive workflows allow users to port high-content imaging data directly into StratoMineR where it is used to generate rich, interactive visualizations using advanced data mining methods. When used with IN Carta Image Analysis Software, it provides robust, quantitative results from complex biological images and datasets utilizing advanced AI technology. Use all of your high-content data to discover, characterize, and analyze Phenotypes.
Latest Resources
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Live Cell Imaging
Live cell imaging is the study of cellular structure and function in living cells via microscopy. It enables the visualization and quantitation of dynamic cellular processes in real time. Live cell imaging encompasses a broad range of topics and biological applications—whether it is performing long-term kinetic assays or fluorescently labeling live cells.
Toxicology
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It is a growing concern in our world today as we are exposed to more and more chemicals, both in our environment and in the products we use.
Resources of IN Carta Image Analysis Software
Blog
3D organoids and automation of complex cell assays [Podcast]
3D organoids and automation of complex cell assays [Podcast]
As we enter the era of sophisticated drug discovery with gene therapy and personalized medicine, we need to be prepared to study complex diseases, assess the therapeutic effect of…
Application Note
Monitoring of T-cell invasions assay using a 3D spheroid model
Monitoring of T-cell invasions assay using a 3D spheroid model
T-cell therapies are designed to help our immune system eliminate cancer cells. Those include CAR T-cells (Chimeric Antigen Receptor engineered T-cells), tumor infiltrating lymphocytes…
Brochure
BioAssemblyBot 400 (BAB400): more than a bioprinter
BioAssemblyBot 400 (BAB400): more than a bioprinter
The BioAssemblyBot® 400 is an intelligent robot used by life scientists to build 3D model systems with increased throughput and precision, alleviating major concerns mentioned above.…
Publications
Overcoming ‘Analysis Paralysis’ in Cell Painting With Artificial Intelligence
Overcoming ‘Analysis Paralysis’ in Cell Painting With Artificial Intelligence
Gone are the days of only measuring single parameters in cell-based experiments. Instead, researchers should widen their focus, namely with the help of innovations like the Cell Pain…
Scientific Poster
Image-based phenotypic profiling using Cell Painting in a 3D breast cancer spheroid model
Image-based phenotypic profiling using Cell Painting in a 3D breast cancer spheroid model
Most potential oncology drugs fail the drug development pipeline, despite having promising data for their efficacy in vitro. This further incentivize the need for identifying in vitr…
Scientific Poster
Automation for organoid assays – An integrated system with high-content imaging
Automation for organoid assays – An integrated system with high-content imaging
Three-dimensional (3D) cell models that represent various tissues are being successfully used in drug discovery and disease modeling to study complex biological effects and tissue ar…
Application Note
Automated Monitoring of Development and Activity Analysis of iPSC-derived 3D Cerebral Organoids
Automated Monitoring of Development and Activity Analysis of iPSC-derived 3D Cerebral Organoids
The human brain is highly complex which makes it challenging to study both in vitro and in-model organisms. Cultured neurons do not sufficiently recapitulate the three-dimensional (3D…
Application Note
AI enabled phenotypic analysis of label-free intestinal organoids
AI enabled phenotypic analysis of label-free intestinal organoids
The intestinal crypt system is an important part of the intestinal organoid where mature organoids have more complex and numerous crypt structures. Yet, due to their high turnover rate…
Blog
Stem Cell Science and Regenerative Medicine – Technology and Methods Presented at ISSCR 2022
Stem Cell Science and Regenerative Medicine – Technology and Methods Presented at ISSCR 2022
It was another great year at ISSCR 2022! Leaders from across the globe came together to discuss new technologies, share insights, and explore the newest breakthroughs in stem cell…
Publications
AI-Powered Phenotypic Profiling Revolutionizes Drug Discovery
AI-Powered Phenotypic Profiling Revolutionizes Drug Discovery
Today, nine out of ten drugs fail in clinical trials. Furthermore, it takes over a decade and an average cost of $2 billion to develop and approve each…
Scientific Poster
Automated monitoring of development and activity analysis of iPSC-derived 3D cerebral organoids
Automated monitoring of development and activity analysis of iPSC-derived 3D cerebral organoids
The culture of complex organoids such as the cerebral organoid is a rapidly developing technology that has immense potential in areas of developmental neurobiology and neurodegenerat…
Scientific Poster
Monitoring growth and characterization of compound effects in 3D intestinal organoids by high content imaging
Monitoring growth and characterization of compound effects in 3D intestinal organoids by high content imaging
3D cell models representing various tissues were successfully used for studying complex biological effects and tissue architecture, however, the complexity of 3D models remains a hur…
Blog
How automated organoid cell cultures are developed, imaged, and analyzed
How automated organoid cell cultures are developed, imaged, and analyzed
3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. Their ability to self-organize and mimic…
eBook
The essential guide to organoids in drug discovery
The essential guide to organoids in drug discovery
Three-dimensional (3D) organoid development is one of the most important advancements in drug discovery research to date.
Application Note
Automation and high content imaging of 3D triple-negative breast cancer patient-derived tumoroids assay for compound screening
Automation and high content imaging of 3D triple-negative breast cancer patient-derived tumoroids assay for compound screening
Triple negative breast cancer is a clinically aggressive tumor subtype, with high rates of metastasis, recurrence, and drug resistance.
Publications
A Picture Paints a Thousand… New Therapies?
A Picture Paints a Thousand… New Therapies?
Cell painting is a high-content profiling technology that uses up to six fluorescent dyes to visualize specific cellular components at the single-cell level. The assay essentially “p…
Brochure
StratoMineR
StratoMineR
Core Life Analytics’ StratoMineR™ software helps biologists analyze the complex data derived from high-content image analysis. A powerful, intuitive workflow allows users to port dat…
Application Note
Increase Cell Painting assay throughput using an automated workstation
Increase Cell Painting assay throughput using an automated workstation
Cell painting has become a popular screening method within the drug discovery community. This phenotypic screening platform leverages advances in high-content microscopy, high-…
Publications
Benefits of Real-Time Live-Cell Imaging
Benefits of Real-Time Live-Cell Imaging
Three-dimensional (3D) cell-based assays replace a host of tissue, cell, and animal test models but have a reputation for lacking time resolution. For e…
Scientific Poster
Phenotypic profiling based on the Cell Painting assay
Phenotypic profiling based on the Cell Painting assay
Multiparametric high-content screening approaches, such as the Cell Painting assay, are increasingly being used in many applications ranging from drug discovery programs to functiona…
Scientific Poster
Intestinal organoids for automated screening assays. High content imaging and analysis of organoid morphology
Intestinal organoids for automated screening assays. High content imaging and analysis of organoid morphology
Here we describe a workflow for automation of organoid culture. The automated method utilizes an integrated work-cell, consisting of several instruments providing automated cell cult…
Application Note
Label-free cell segmentation with IN Carta SINAP application module
Label-free cell segmentation with IN Carta SINAP application module
Label-free cell analysis provides a better alternative to using fluorescent dyes as it enables scientists to image live cells under near-native conditions – examining biological…
Blog
Engineering Next-gen Organoids with Automated Lab Workflows at #SLAS2022
Engineering Next-gen Organoids with Automated Lab Workflows at #SLAS2022
SLAS2022, the Society for Lab Automation and Screening conference offered another exciting year for learning about innovative laboratory technologies. Whether you attended in-person…
Application Note
Improving the robustness of Cell Painting with a near-infrared label and advanced image and data analytics
Improving the robustness of Cell Painting with a near-infrared label and advanced image and data analytics
Image-based phenotypic profiling approaches such as the widely used Cell Painting assay use high-content imaging along with multiparametric readouts to study biological, genetic, and…
Scientific Poster
Automation of 3D organoid culture workflow with deep-learning based image analysis
Automation of 3D organoid culture workflow with deep-learning based image analysis
3D cell culture as a model system is increasingly popular because it recapitulates the in vivo microenvironment better than 2D cell cultures. Organoids have the capacity for stable d…
Scientific Poster
Automation and high content imaging of 3D triple-negative breast cancer patient-derived
Automation and high content imaging of 3D triple-negative breast cancer patient-derived
Triple negative breast cancer is a clinically aggressive tumor subtype, with high rates of metastasis, recurrence, and drug resistance. Currently there are no clinically approved sma…
Scientific Poster
Improving the robustness of Cell Painting with a near-infrared label and advanced image and data analytics
Improving the robustness of Cell Painting with a near-infrared label and advanced image and data analytics
Image-based phenotypic profiling approaches, such as the widely-used Cell Painting assay, use high-content imaging along with multiparametric readouts to study biological, genetic, a…
Application Note
Deep Learning-based Image Analysis for Label-free Live Monitoring of iPSC and 3D Organoid Cultures
Deep Learning-based Image Analysis for Label-free Live Monitoring of iPSC and 3D Organoid Cultures
Complex 3D biological models such as organoids and patient-derived spheroids are gaining popularity in many biomedical research areas because they more closely recapitulate the in vivo…
Blog
Innovation at Molecular Devices: Updates in Automated, High-Content Imaging
Innovation at Molecular Devices: Updates in Automated, High-Content Imaging
From customer feedback to workflow improvements The path to understanding complex biological processes and diseases is paved with a lot of challenges. As the desired level of…
Blog
Stem cell science insights and breakthroughs presented at #ISSCR2021
Stem cell science insights and breakthroughs presented at #ISSCR2021
If you didn't get a chance to visit us at our poster sessions during ISSCR 2021, don’t fret. We've gathered all our sessions right here for you. The ISSCR Annual Meeting brought…
Application Note
Organoids for disease modeling and in vitro drug screening
Organoids for disease modeling and in vitro drug screening
We describe an automated integrated system that would allow automated monitoring, maintenance, and characterization of growth and differentiation of organoids and stem cells, as well…
Publications
Project Profile: Organoid Innovation Center
Project Profile: Organoid Innovation Center
Lab Manager speaks to Dan O’Connor, vice president, drug discovery, Molecular Devices, about the company’s Organoid Innovation Center in San Jose, CA. The center is 180 sq. ft., with…
Publications
Organs-on-Chips: Expand the Boundaries of In Vitro Testing
Organs-on-Chips: Expand the Boundaries of In Vitro Testing
Humans began culturing animal cells and tissues as early as the late 19th century, when Wilhelm Roux first showed that chick embryos could be cultured in saline solution for a few da…
Brochure
IN Carta Image Analysis Software
IN Carta Image Analysis Software
IN Carta™ Image Analysis Software solves complex image analysis problems utilizing advanced Artificial Intelligence (AI) turning images into data. Easy-to-use workflows help you get…
Blog
Tips for running a successful live cell imaging experiment
Tips for running a successful live cell imaging experiment
There have been significant advancements in microscopy and camera technology, as well as advancements in technologies for labeling molecules of interest over the past decade. These…
Publications
Shaping the Future of Organoid Research
Shaping the Future of Organoid Research
Molecular Devices, a provider of innovative life science technology, recently unveiled a brand new, first-of-its-kind Organoid Innovation Center. Situated at the company’s global hea…
Blog
Overcome the challenges of high-content cell analysis through AI/machine learning
Overcome the challenges of high-content cell analysis through AI/machine learning
Artificial intelligence (AI) is finding its way into many aspects of modern life, from autonomous vehicles to voice-powered personal assistants, and even the creation of art. But it…
Blog
How Cell Painting is making its mark on drug discovery
How Cell Painting is making its mark on drug discovery
Have you ever heard the old adage, “A picture is worth a thousand words?” When it comes to Cell Painting, this saying is especially true. Cell Painting is a high-content,…
Publications
Danaher’s SCIEX and Molecular Devices Businesses Debut New Products
Danaher’s SCIEX and Molecular Devices Businesses Debut New Products
It has been a busy beginning of the year for Danaher’s Life Sciences segment. In January, the business reported 2020 revenues of $10.6 billion, represen…
Blog
Life sciences technology predictions for 2021
Life sciences technology predictions for 2021
For over 30 years, Molecular Devices has been at the forefront of technological advances which have contributed to significant scientific breakthroughs. To kick off the new year, we…
Publications
Rising growth of the global high‑content screening software and services market
Rising growth of the global high‑content screening software and services market
Developments in informatics solutions and high-content imaging instruments, increased focus on cell-based research, and rising government support of research and development for drug…
Brochure
Innovative Solutions for Drug Discovery and Life Sciences Research
Innovative Solutions for Drug Discovery and Life Sciences Research
Molecular Devices is a leading provider of high-performance bioanalytical measurement solutions for life science research, pharmaceutical development, and biotherapeutic discovery. O…


3D Imaging Seminar Series

New standard in organoid culture and image-based analyses

Automate your 3D biology high-throughput workflows

Leverage automated, end-to-end workflows to enable complex organoid assays

Level Up your 3D Cell Culture: From Research to High-Throughput

Enhance high-content 3D biology imaging with automated sample preparation

Enhancing 3D Disease Models: Automated, High-Throughput, Phenotypic Screening with Organ-on-a-Chip

High-Content Phenotypic Screening

Emerging Organoid Models: Translating Basic Research to Drug Development and Regenerative Medicine

Automating culture and high-content imaging of 3D organoids for in vitro assessment of compound effects

Deep Learning-Based Image Analysis for Label-Free Live Monitoring of iPSC and 3D Organoid Cultures

Monitoring organoid development in iPSC-derived 3D cerebral organoids

ISSCR 2021 Innovation Showcase: Automated Culture and High-Content Imaging of 3D Lung and Cardiac
- Dated: May 16, 2022Publication Name: Aging
Senescence-associated morphological profiles (SAMPs): an image-based phenotypic profiling method for evaluating the inter and intra model heterogeneity of senescence
Senescence occurs in response to a number of damaging stimuli to limit oncogenic transformation and cancer development. As no single, universal senescence marker has been discovered, the confident classification of senescence induction requires the parallel assessment of a series of hallmarks. Therefore, there is a growing need for “first-pass”… View moreSenescence occurs in response to a number of damaging stimuli to limit oncogenic transformation and cancer development. As no single, universal senescence marker has been discovered, the confident classification of senescence induction requires the parallel assessment of a series of hallmarks. Therefore, there is a growing need for “first-pass” tools of senescence identification to streamline experimental workflows and complement conventional markers.
Contributors: Ryan Wallis, Deborah Milligan, Bethany Hughes, Hannah Mizen, José Alberto López-Domínguez, Ugochim Eduputa, Eleanor J. Tyler, Manuel Serrano, Cleo L. Bishop
Go to article - Dated: Feb 01, 2022Publication Name: ScienceDirect
Virtual screening and in vitro validation of natural compound inhibitors against SARS-CoV-2 spike protein
The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to a major public health burden and has resulted in millions of deaths worldwide. As effective treatments are limited, there is a significant requirement for high-throughput, low resource methods for the discovery of novel antivirals. The SARS-CoV-2 spike protein plays a key role in… View moreThe COVID-19 pandemic caused by the SARS-CoV-2 virus has led to a major public health burden and has resulted in millions of deaths worldwide. As effective treatments are limited, there is a significant requirement for high-throughput, low resource methods for the discovery of novel antivirals. The SARS-CoV-2 spike protein plays a key role in viral entry and has been identified as a therapeutic target.
Contributors: Helen Power, Jiadai Wu, Stuart Turville, Anupriya Aggarwal, Peter Valtchev, Aaron Schindeler, Fariba Dehghani
Go to article - Dated: Nov 03, 2021Publication Name: American Chemical Society
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L
Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as potent inhibitors of cathepsin L with IC50 values in the picomolar range. Lead molecules possessed… View moreCathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic analogues were identified as potent inhibitors of cathepsin L with IC50 values in the picomolar range. Lead molecules possessed selectivity over other cathepsins and alternative host proteases involved in viral entry. Gallinamide A directly interacted with cathepsin L in cells and, together with two lead analogues, potently inhibited SARS-CoV-2 infection in vitro, with EC50 values in the nanomolar range. Reduced antiviral activity was observed in cells overexpressing transmembrane protease, serine 2 (TMPRSS2); however, a synergistic improvement in antiviral activity was achieved when combined with a TMPRSS2 inhibitor. These data highlight the potential of cathepsin L as a COVID-19 drug target as well as the likely need to inhibit multiple routes of viral entry to achieve efficacy.
Contributors: Anneliese S. Ashhurst, Arthur H. Tang, Pavla Fajtová, Michael C. Yoon, Anupriya Aggarwal, Max J. Bedding, Alexander Stoye, Laura Beretta, Dustin Pwee, Aleksandra Drelich, Danielle Skinner, Linfeng Li, Thomas D. Meek, James H. McKerrow, Vivian Hook, Chien-Te Tseng, Mark Larance, Stuart Turville, William H. Gerwick*, Anthony J. O’Donoghue*, and Richard J. Payne*
Go to article - Dated: Nov 01, 2021Publication Name: AAN PUBLICATIONS
GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti–Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disorder
To analyze (1) the effect of immunoglobulin G (IgG) from patients with anti–myelin oligodendrocyte glycoprotein antibody (MOG-Ab)–associated disorder on the blood-brain barrier (BBB) endothelial cells and (2) the positivity of glucose-regulated protein 78 (GRP78) antibodies in MOG-Ab–associated disorders. View moreTo analyze (1) the effect of immunoglobulin G (IgG) from patients with anti–myelin oligodendrocyte glycoprotein antibody (MOG-Ab)–associated disorder on the blood-brain barrier (BBB) endothelial cells and (2) the positivity of glucose-regulated protein 78 (GRP78) antibodies in MOG-Ab–associated disorders.
Contributors: Fumitaka Shimizu, Ryo Ogawa, Yoichi Mizukami, Kenji Watanabe, Kanako Hara, Chihiro Kadono, Toshiyuki Takahashi, View ORCID ProfileTatsuro Misu, Yukio Takeshita, Yasuteru Sano, Miwako Fujisawa, Toshihiko Maeda, View ORCID ProfileIchiro Nakashima, Kazuo Fujihara, Takashi Kanda
Go to article - Dated: Sep 24, 2021Publication Name: ScienceDirect
Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection
The development of a safe and effective vaccine is a key requirement to overcoming the COVID-19 pandemic. Recombinant proteins represent the most reliable and safe vaccine approach but generally require a suitable adjuvant for robust and durable immunity. We used the SARS-CoV-2 genomic sequence and in silico structural modelling to design a… View moreThe development of a safe and effective vaccine is a key requirement to overcoming the COVID-19 pandemic. Recombinant proteins represent the most reliable and safe vaccine approach but generally require a suitable adjuvant for robust and durable immunity. We used the SARS-CoV-2 genomic sequence and in silico structural modelling to design a recombinant spike protein vaccine (Covax-19™).
Contributors: LeiLia, Yoshikazu Honda-Okubo, Ying Huang, HyesunJang, Michael A. Carlock, Jeremy Baldwin, Sakshi Piplani, Anne G.Bebin-Blackwell, DavidForgacs, Kaori Sakamoto, Alberto Stella, Stuart Turville, Tim Chataway, Alex Colella, Jamie Triccas, Ted M. Ross, Nikolai Petrovsky
Go to article - Dated: Apr 20, 2021Publication Name: ScienceDirect
Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection
Considerable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence of antibody titers declining rapidly after infection and reports of reinfection. Here, we monitor the antibody responses against SARS-CoV-2 receptor-binding domain (RBD) for up to 6 months… View moreConsiderable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence of antibody titers declining rapidly after infection and reports of reinfection. Here, we monitor the antibody responses against SARS-CoV-2 receptor-binding domain (RBD) for up to 6 months after infection. While antibody titers are maintained, ∼13% of the cohort’s neutralizing responses return to background.
Contributors: Arunasingam Abayasingam, Harikrishnan Balachandran, David Agapiou, Mohamed Hammoud, Chaturaka Rodrigo, Elizabeth Keoshkerian, Hui Li, Nicholas A. Brasher, Daniel Christ, Romain Rouet, Deborah Burnet, Branka Grubor-Bauk, William Rawlinson, StuartTurville, Anupriya Aggarwal, Alberto Ospina Stella, Christina Fichter, Fabienne Brilot…Rowena A. Bull
Go to article
Explore our high-content imaging portfolio
High-content imaging and analysis solutions, ranging from automated digital microscopy to high-throughput confocal imaging systems with water immersion objectives and proprietary spinning disk technology.
Advanced Cloud-Based Analytics with StratoMineR
Increase efficiency and throughput with cloud-based advanced analytics

IN Carta Image Analysis Software
Provides robust, quantitative results from complex biological images and datasets

Cellular Imaging Systems
Transform your incredible images into captivating results
How can we help advance your next big discovery?
Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today?
I’d like to…
How can we help advance your next big discovery?
Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today?
I’d like to…