Axon Patch-Clamp
The complete workflow solution for patch-clamp electrophysiology
- Most widely-used patch-clamp electrophysiology software
- Multi-channel experiments can be performed
- Signal-to-noise ratios close to theoretical limits of physics
Systems for whole cell patch-clamp, extracellular, and single-channel recordings
The Axon Instruments® portfolio provides comprehensive solutions for patch-clamping that includes amplifiers, digitizer, software, and accessories. Our best-in-class instruments facilitate the entire range of patch-clamp technique experiments from the smallest single-channel to the largest macroscopic recordings. With the addition of Axon™ pCLAMP™ 11 Software Suite for acquisition, recording and analysis, a truly streamlined workflow is realized.
Eliminate line-frequency noise
The HumSilencer™ feature removes 50/60 hz line-frequency noise on up to four channels in parallel. The function is quickly enabled through a software checkbox.
Maximize signal-to-noise ratio
The Axopatch™ 200B Amplifier offers one of the lowest-noise, single-channel recordings available via an innovative actively cooled headstage with capacitor-feedback technology.
Streamline workflows
pCLAMP Software offers a selection of modules and tools that simplifies setup and enables automation of parameters.
University of Texas uses the Axon Patch-Clamp Systems to evaluate signaling mechanisms in the brain underlying memory and recall
Allegheny College uses our Axon patch-clamp instruments to investigate how amyloid beta peptide block ion channels in Alzheimer's disease
A complete workflow solution for patch-clamp electrophysiology
Amplification—amplify your success
- Control via pCLAMP software maximizes flexibility in setting up and performing different experimental protocols
- A wide range of amplifiers means we can offer the ideal choice for your application, providing the best possible data
- Our lowest-noise amplifier/digitizer instruments provide the highest signal resolution, and eliminate 50 or 60 Hz line-frequency noise contamination
Axon Instruments Patch-Clamp Amplifiers
The Axon™ Digidata® 1550B plus HumSilencer®
Digitization—get better data, faster
- High rate of sampling (500kHz) means a more faithful digitization process, allowing for precise digital reconstruction of the analogue signal due to minimal information loss
- Eight channels can be sampled and digitized simultaneously, increasing data acquisition speed
- The HumSilencer option with the Digidata range eliminates of 50 and 60Hz line-frequency noise, making the biological signal clearer without distorting the data
Acquisition — get more flexibility and easier acquisition
- Enhanced protocol editor in pCLAMP 11 Software allows for longer and more sophisticated protocols to be programmed and reduces protocol setup time
- Multiple windows can be simultaneously displayed during a Membrane Test protocol, making it easier to patch multiple cells
- Gap-free mode allows the programming of command and digital outputs in a continuous recording, allowing you to enhance protocol design and trigger actions within the protocol automatically
Analysis—discover more while saving time
- Acquisition and analysis are combined in one package, streamlining the entire process
- Advanced modules allow action potential and population spike measurements to be made automatically
- New Batch Analysis feature allows multiple datasets to be analysed using an identical macro; saving time on data analysis and ensuring the exact same analysis is carried out on each dataset
pCLAMP 11 Software Suite
Featured resources for electrophysiology and the Axon patch-clamp system
APPLICATIONS
Patch-Clamp Electrophysiology
The Patch-clamp technique is a versatile electrophysiological tool for understanding ion channel behavior. Every cell expresses ion channels...
VIDEO GALLERY
Axon Patch-Clamp Video Gallery
Explore Axon Patch-Clamp videos and webinars. Learn how they provide best-in-class solutions for the entire range of patch-clamp experiments.
EBOOK
The Axon Guide
The most comprehensive laboratory techniques workbook—with over 250 pages—to support electrophysical and biophysical research.
TECHNOLOGY
Electrophysiology
Learn about electrophysiology - the field of research studying current or voltage changes across a cell memberane.
TECHNOLOGY
HumSilencer Technology
50/60 Hz line-frequency noise, also known as electrical hum, is the most common source of background noise in patch-clamp electrophysiology experiments.
The Axon Instruments® portfolio
How can we help advance your next big discovery?
Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today?
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