Custom Organoid Expansion Service
Providing large batches of standardized assay-ready organoids
Providing large batches of standardized assay-ready organoids
Molecular Devices has global leadership in the scale-up and industrial manufacturing of human-derived 3D organoids using our proprietary bioreactor and patent-pending bioprocess technology. Organoids offer significant benefits over 2D monolayer cultures as a research platform, as they can recapitulate the architecture, physiology, and underlying genetic signature of primary tissues.
Organoids can model complex in vivo processes in vitro. Using human materials, such as Patient-Derived Organoids (PDOs), earlier in research and development provides biotech and pharma with patient-centric models that give more applicable results, potentially enabling a reduction in the use of animals and animal tissues.
PDOs model cell interactions and tissue function
Suitable for use in high-throughput applications
Fully representative of human biology
Can be used in immune & cell therapy applications
Our semi-automated bioprocess minimizes handling and reduces operator variability. This enables us to produce consistent and reproducible batches of homogeneous organoids.
Molecular Devices technology is at the forefront of the implementation of 3D organoid models. We facilitate the provision of patient-derived organoids at scale for pharmaceutical companies, contract research organizations, and academic institutions. We specialize in applications such as drug discovery, that require large quantities of high-quality, standardized organoids in reproducible batches.
Brain organoids are 3D tissue models representing one or more regions of the brain. They can overcome the shortcomings of conventional post-mortem and animal brain models to produce clinically relevant results.
Cerebral organoids have great potential for understanding brain development and neuronal diseases. They can also be used for investigating genetic disorders and the effects of compounds. Nevertheless, capturing the uniqueness of the human brain requires functional assays and high-content imaging systems.
Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.
For every drug that makes it to the finish line, another nine don’t succeed. This alarming failure rate can be traced to reliance on 2D cell cultures that don’t closely mimic complex human biology, often leading to inaccurate predictions of a drug’s potential and extended drug development timelines.
Intestinal organoids are 3D tissue models that recapitulate structures in the intestinal lumen and on the surrounding intestinal epithelium.
The cell composition and arrangement of the epithelium make intestinal organoids useful for studying intestinal cell biology, regeneration, differentiation, as wells as diseases phenotypes including effects of specific mutations, microbiome, or inflammation process.
Our lab automation solutions include scientists and engineers who can customize our instruments, as well as automate entire workflows to meet the specific needs of your assay, method, or protocol. From incubators, liquid handlers, and robotics to customized software and hardware—and with over 35 years of experience in the life science industry—you can count on us to deliver quality products and provide worldwide support.
Learn more about how robotics-driven automation workcells and AI-based image analysis can help you develop an efficient, end-to-end workflow for your organoid development process.
Organoids are three-dimensional (3D) multi-cellular microtissues that are designed to closely mimic the complex structure and functionality of human organs. Organoids typically consist of a co-culture of cells which demonstrate a high order of self-assembly to allow for an even better representation of complex in vivo cell responses and interactions, as compared to traditional 2D cell cultures.
Patient-derived tumor organoids or tumoroids are cultures of tumor cells that can be generated from individual patients. Tumoroids are highly valuable tools for cancer research, drug development, and personalized medicine.
Early detection and treatment are crucial in the survival rate of breast cancer patients. This necessitates the use of clinically relevant tumor models to understand the mechanism, analyze tumor biomarkers, and screen anticancer drugs. Breast cancer tumoroids provide the platform to study tumor physiology and response to targeted therapies.
Learn how to analyze breast cancer tumoroid growth and the efficacy of anticancer treatments with high-throughput screening and high-content imaging solutions:
Lung organoid cultures are 3D microtissue models recapitulating the morphological and functional characteristics of the airway, such as mucus secretion, ciliary beating, and regeneration. This biological relevance enables the study of repair/regeneration mechanisms in lung injury and phenotypic changes in pulmonary diseases. Lung organoids also can be used for toxicity assessment or drug testing.
Pluripotent stem cells can be used for studies in developmental biology or differentiated as a source for organ-specific cells and used for live or fixed cell-based assays on slides or in multi-well plates. The ImageXpress system has utility in all parts of the stem cell researcher’s workflow, from tracking differentiation, to quality control, to measuring functionality of specific cell types.
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It is a growing concern in our world today as we are exposed to more and more chemicals, both in our environment and in the products we use.
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Molecular Devices has global leadership in the scale-up and industrial manufacture of human-derived 3Dorganoids using our proprietary bioprocess. Organoids offer significant benefits ov…
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Patient derived organoids (PDOs) represent a promising tool to reduce pipeline attrition in drug discovery. These tumor organoids are multicellular mini replicas of the 3D tumor and…
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Many oncology drugs fail at the later stages of the drug development pipeline and in clinical trials, despite promising data for their efficacy in vitro. This high failure rate is…
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Following our acquisition of Cellesce Ltd, Tanya Samazan from Instrument Business Outlook dove deep into conversation with Molecular Devices President Susan Murphy and Cellesce CEO V…
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First-of-its-kind technology from Cellesce creates consistent patient-derived organoids for large scale drug screening Acquisition strengthens Molecular Devices’ position as a 3D…
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3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. Their ability to self-organize and mimic…
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The use of patient-derived tumor tissue has transformed the field of drug and target discovery research, providing a translational tool and physiologically relevant system to evaluate…
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Are Organoids the Future of Drug Discovery?
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Transform your incredible images into captivating results
Quality-controlled organoids are manufactured at scale for high-throughput screening, leveraging proprietary bioreactor and patent-pending bioprocess technology to produce efficient, reproducible, scalable PDOs. These can be deployed in many applications, including drug discovery and organ-on-a-chip applications.
Until recently, organoids could only be grown and expanded manually. This is a technically challenging, time-consuming, and labor-intensive process resulting in small numbers of inconsistently sized organoids, limiting their suitability for use in high throughput applications and widespread use by big pharma and biotech.
This 'disruptive’ Molecular Devices bioprocess, now in its second generation, has enabled a significant increase in standardized PDO volume production compared to manual processes. Improved process control, including the use of inline sensors and real-time monitoring, ensures precise culture conditions for large, reproducible batches of standardized organoids. This is a significant step change from existing manual PDO culture methods, enabling organoids to be used in high-throughput assays earlier in the drug discovery cascade.
Brain organoids are 3D tissue models representing one or more regions of the brain. They can…
Cancer researchers need tools that enable them to more easily study the complex and often poorly…
For every drug that makes it to the finish line, another nine don’t succeed. This alarming failure…
Intestinal organoids are 3D tissue models that recapitulate structures in the intestinal lumen and…
Our lab automation solutions include scientists and engineers who can customize our instruments, as…
Organoids are three-dimensional (3D) multi-cellular microtissues that are designed to closely mimic…
Patient-derived tumor organoids or tumoroids are cultures of tumor cells that can be generated from…
Lung organoid cultures are 3D microtissue models recapitulating the morphological and functional…
Pluripotent stem cells can be used for studies in developmental biology or differentiated as a…
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It…
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