Expand organoids at scale using our patent-pending bioprocess technology


Molecular Devices has global leadership in the scale-up and industrial manufacturing of human-derived 3D organoids using our proprietary bioreactor and patent-pending bioprocess technology. Organoids offer significant benefits over 2D monolayer cultures as a research platform, as they can recapitulate the architecture, physiology, and underlying genetic signature of primary tissues.

Organoids can model complex in vivo processes in vitro. Using human materials, such as Patient-Derived Organoids (PDOs), earlier in research and development provides biotech and pharma with patient-centric models that give more applicable results, potentially enabling a reduction in the use of animals and animal tissues.

  • Expansion Service

    Organoid line expansion service

    We offer a unique, bespoke service to scale-up your own organoid lines using our patent pending bioprocess, which can produce up to 6 million organoids per batch. Large batches such as this are needed to facilitate drug discovery, for example, to screen hundreds to thousands of drug candidates in parallel and to increase statistical power.

  • Cell organoids

    Assay-ready organoids

    After expansion, the bioprocess-grown organoids can be supplied back to you as customized assay-ready vials to be used at your convenience for specific downstream assays.

  • Factory generation

    Bespoke PDO line generation

    We can also generate and grow custom PDO lines derived from patient-derived xenograft (PDX) tissue.

Assay-Ready Organoids

Assay-Ready Organoids


  • Multicellular

    Multicellular & 3D

    PDOs model cell interactions and tissue function

  • Scalable

    Scalable and reproducible

    Suitable for use in high-throughput applications

  • Microscope

    Faithful and predictive

    Fully representative of human biology

  • Immune cells

    Can add immune cells

    Can be used in immune & cell therapy applications

Custom organoid expansion workflow

Our semi-automated bioprocess minimizes handling and reduces operator variability. This enables us to produce consistent and reproducible batches of homogeneous organoids.

Molecular Devices technology is at the forefront of the implementation of 3D organoid models. We facilitate the provision of patient-derived organoids at scale for pharmaceutical companies, contract research organizations, and academic institutions. We specialize in applications such as drug discovery, that require large quantities of high-quality, standardized organoids in reproducible batches.

Custom organoid exp

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Applications of Custom Organoid Expansion Service

  • Brain Organoids

    Brain (Cerebral) Organoids

    Brain organoids are 3D tissue models representing one or more regions of the brain. They can overcome the shortcomings of conventional post-mortem and animal brain models to produce clinically relevant results.

    Cerebral organoids have great potential for understanding brain development and neuronal diseases. They can also be used for investigating genetic disorders and the effects of compounds. Nevertheless, capturing the uniqueness of the human brain requires functional assays and high-content imaging systems.

    Learn more about brain organoids 

    Cancer Research

    Cancer Research

    Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.

    Learn More  

  • Drug Discovery and Development

    Drug Discovery and Development

    For every drug that makes it to the finish line, another nine don’t succeed. This alarming failure rate can be traced to reliance on 2D cell cultures that don’t closely mimic complex human biology, often leading to inaccurate predictions of a drug’s potential and extended drug development timelines.

    Learn More  

    Intestinal Organoids

    Intestinal Organoids

    Intestinal organoids are 3D tissue models that recapitulate structures in the intestinal lumen and on the surrounding intestinal epithelium.

    The cell composition and arrangement of the epithelium make intestinal organoids useful for studying intestinal cell biology, regeneration, differentiation, as wells as diseases phenotypes including effects of specific mutations, microbiome, or inflammation process.

    Learn more about intestinal organoids 

  • Organoid Innovation Center

    Organoid Innovation Center

    Our lab automation solutions include scientists and engineers who can customize our instruments, as well as automate entire workflows to meet the specific needs of your assay, method, or protocol. From incubators, liquid handlers, and robotics to customized software and hardware—and with over 35 years of experience in the life science industry—you can count on us to deliver quality products and provide worldwide support.

    Learn more about how robotics-driven automation workcells and AI-based image analysis can help you develop an efficient, end-to-end workflow for your organoid development process.



    Organoids are three-dimensional (3D) multi-cellular microtissues that are designed to closely mimic the complex structure and functionality of human organs. Organoids typically consist of a co-culture of cells which demonstrate a high order of self-assembly to allow for an even better representation of complex in vivo cell responses and interactions, as compared to traditional 2D cell cultures.

    Learn More 

  • Patient-derived organoids (Tumoroids)

    Patient-derived organoids

    Patient-derived tumor organoids or tumoroids are cultures of tumor cells that can be generated from individual patients. Tumoroids are highly valuable tools for cancer research, drug development, and personalized medicine.

    Early detection and treatment are crucial in the survival rate of breast cancer patients. This necessitates the use of clinically relevant tumor models to understand the mechanism, analyze tumor biomarkers, and screen anticancer drugs. Breast cancer tumoroids provide the platform to study tumor physiology and response to targeted therapies.

    Learn how to analyze breast cancer tumoroid growth and the efficacy of anticancer treatments with high-throughput screening and high-content imaging solutions:

    Learn more about patient-derived breast cancer tumoroids 

    Pulmonary (Lung) Organoids

    Pulmonary (Lung) Organoids

    Lung organoid cultures are 3D microtissue models recapitulating the morphological and functional characteristics of the airway, such as mucus secretion, ciliary beating, and regeneration. This biological relevance enables the study of repair/regeneration mechanisms in lung injury and phenotypic changes in pulmonary diseases. Lung organoids also can be used for toxicity assessment or drug testing.

    Learn more about lung organoids 

  • Stem Cell Research

    Stem Cell Research

    Pluripotent stem cells can be used for studies in developmental biology or differentiated as a source for organ-specific cells and used for live or fixed cell-based assays on slides or in multi-well plates. The ImageXpress system has utility in all parts of the stem cell researcher’s workflow, from tracking differentiation, to quality control, to measuring functionality of specific cell types.

    Learn more 



    Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It is a growing concern in our world today as we are exposed to more and more chemicals, both in our environment and in the products we use.

    Read More 

Resource of Custom Organoid Expansion Service

Videos & Webinars
Are organoids the future of Drug Discovery

Are Organoids the Future of Drug Discovery?

patient-derived Tumoroids

The search for answers: Using lab automation with patient-derived tumoroids to find more relevant therapies for clinically aggressive cancers

Organoid expansion process – efficient, reproducible, scalable

Quality-controlled organoids are manufactured at scale for high-throughput screening, leveraging proprietary bioreactor and patent-pending bioprocess technology to produce efficient, reproducible, scalable PDOs. These can be deployed in many applications, including drug discovery and organ-on-a-chip applications.

Until recently, organoids could only be grown and expanded manually. This is a technically challenging, time-consuming, and labor-intensive process resulting in small numbers of inconsistently sized organoids, limiting their suitability for use in high throughput applications and widespread use by big pharma and biotech.

Organoid expansion process – efficient, reproducible, scalable

This 'disruptive’ Molecular Devices bioprocess, now in its second generation, has enabled a significant increase in standardized PDO volume production compared to manual processes. Improved process control, including the use of inline sensors and real-time monitoring, ensures precise culture conditions for large, reproducible batches of standardized organoids. This is a significant step change from existing manual PDO culture methods, enabling organoids to be used in high-throughput assays earlier in the drug discovery cascade.

Generation Bioprocess