Overcoming Bottlenecks in Organoid Production
Molecular Devices Expert Discusses Overcoming Bottlenecks in Organoid Production
Dr. Vicky Marsh Durban, PhD, Director of Human Relevant Models at Molecular Devices, shares insights on advancing scalable, standardized organoid workflows with Technology Networks, highlighting how bioreactor-based approaches can transform organoid culture and support reproducible, high-throughput research.
Key Insights
• Addressing Traditional Challenges: Manual organoid culture remains labor-intensive and variable, limiting reproducibility and scalability in complex biology workflows.
• Bioreactor-Driven Standardization: Controlled seeding and size-selection in bioreactor systems enable more uniform, assay-ready organoids at scale—critical for high-throughput applications.
• Supporting High-Throughput Research: Scalable organoid production helps researchers expand experimental capacity without extensive manual oversight.
• Enabling Cross-Lab Consistency: Standardized, reproducible organoid batches help reduce experimental noise and improve confidence in biological outcomes.
• Driving Adoption of Complex Models: Lowering barriers to use and improving reliability supports broader adoption of human-relevant 3D models in drug discovery and biological research.
Summary
In a recent Technology Networks interview, Anna MacDonald speaks with Dr. Vicky Marsh Durban, PhD, Director of Human Relevant Models at Molecular Devices, about overcoming critical bottlenecks in organoid culture and production. Traditional manual methods are time-consuming and introduce significant batch variability, making reproducible workflows difficult. Dr. Marsh Durban explains how controlled bioreactor-based approaches—featuring defined seeding and size selection—enable production of uniform, assay-ready organoids at scale. These scalable methods not only reduce hands-on time but also support larger screening studies and cross-laboratory consistency, addressing major challenges in the adoption of complex biological models. The discussion underscores how standardized workflows help researchers focus on experimental design and data analysis rather than routine culture tasks, ultimately accelerating drug discovery and enabling more robust biological insights.
Read the Full Article
This summary is based on insights from Molecular Devices’ Dr. Vicky Marsh Durban, PhD., as featured in the Technology Networks article, “Overcoming Bottlenecks in Organoid Production.”