Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers

Multi-Dimensional in Vitro Bioactivity

High-content screening data derived from physiologically-relevant in vitro models promise to improve confidence in data-integrative groupings for read-across in human health safety assessments. The biological data-based read-across concept is especially applicable to bioactive chemicals with defined mechanisms of toxicity; however, the challenge of data-derived groupings for chemicals that are associated with little or no bioactivity has not been explored.

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