Dated: Mar 24, 2023
Publication Name: Experimental and Therapeutic Medicine
Citations : Increased ENT2 expression and its association with altered purine metabolism in cell lines derived from different stages of colorectal cancer
Colorectal cancer (CRC) is one of the most prevalent malignant cancer types worldwide. Although the purine metabolism pathway is vital for cancer cell survival, little is known about the role of equilibrative nucleoside transporter 2 (ENT2) in CRC development and its association with purine metabolites. The aim of the present study was to evaluate the levels of hypoxanthine phosphoribosyl transferase (HPRT), hypoxanthine and uric acid (UA), as well as xanthine oxidase (XO) activity, and investigate their association with ENT2 expression levels in a normal human colon cell line and CRC cell lines derived from different stages of CRC.
Contributors: Safaa M. Naes, Sharaniza Ab-Rahim, Musalmah Mazlan, Nurul Azmir Amir, Hashim and Amirah Abdul Rahman