Dated: Dec 01, 2023
Publication Name: Journal of functional foods
Citations : In vitro assessment of dietary bioactives for TFEB activation as a possible target to support cognitive and emotional wellbeing
Aging and chronic stress are associated with altered brain plasticity and an increased risk of developing cognitive and emotional health problems. A key cellular mechanism involved is autophagy, which is known to be important for memory encoding and information processing, and is also thought to be important for psychiatric and emotional health. Activation of the autophagic system can be established by the transcription factor EB (TFEB), which regulates both autophagosome formation and lysosomal biogenesis and function. As well-known activators of autophagy like caloric restriction, fasting, or regular exercise require intervention programs that are hard to adhere to, the search for nutritional solutions with similar effects, is increasing. We therefore evaluated pro-autophagic dietary bioactives for effects specifically through TFEB activation and assessed whether combining bioactives can lead to synergistic or additive effects. We also discuss current evidence supporting the use of these natural dietary compounds to promote cognitive and emotional wellbeing.
Contributors: Laura Trovò, Angélique Vaucher, Yuanlong Pan, Pascal Steiner, Stefanie Flunkert, Stephen A. Fleming, Nicolas Preitner