Dated: Apr 14, 2023
Publication Name: Purinergic Signalling
Citations : Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages
The activation of P2X7 is a well-known stimulus for the NLRP3-caspase 1 inflammasome and subsequent rapid IL-1β secretion from monocytes and macrophages. Here we show that positive allosteric modulators of P2X7, ginsenosides, can enhance the release of three important cytokines, IL-1β, IL-6 and TNF-α from LPS-primed rodent macrophages using the J774 mouse macrophage cell line and primary rat peritoneal macrophages.
Contributors: Kshitija Dhuna, Ray Helliwell, Simone N. De Luca, Sarah J. Spencer & Leanne Stokes