Dated: Jun 02, 2023
Publication Name: Heart
Citations : BS62 ‘Cardiac organoids. A model to investigate the effect of diabetes on cardiac development and function’
Introduction Diabetes and associated cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood vessels. Despite progress in clinical research and therapy, CVDs still represent the leading cause of mortality and morbidity worldwide. The hallmarks of cardiac diseases include heart dysfunction and cardiomyocyte death, inflammation, fibrosis, scar tissue, hyperplasia, hypertrophy, and abnormal ventricular remodelling. The loss of cardiomyocytes is an irreversible process that leads to fibrosis and scar formation, which, in turn, induce heart failure with progressive and dramatic consequences. Both genetic and environmental factors pathologically contribute to the development of CVDs, but the precise causes that trigger cardiac diseases and their progression are still largely unknown.
Contributors: Magdalini Eleftheriadou, Hojjat Naderi-Meshkin, Koray N Potel, Wiwit Ananda Wahyu Setyaningsih, Andrew Yacoub, Alan W Stitt, David J Grieve, Andriana Margariti