Event Details

Nov 3, 2016

Using spheroid models to develop relevant high-throughput assays with quantitative endpoints

  • Webinars
  • North America

Significant advances in automated microscopy, imaging, and biological models are delivering more predictive, p- hysiologically-relevant measurements for drug discovery and environmental toxicity applications. Yet, implementation challenges have been a deterrent for utilizing 3D spheroid models.

In collaboration with Cellular Dynamics International and Corning Life Sciences, we will explore the use and analysis of cancer spheroid models, as well as iPSC-derived hepatocyte and cardiomyocyte spheroids for toxicity assessment and demonstrate that historical barriers have been overcome.

Join us to learn about:

  • Selecting products and solutions for implementation of 3D spheroid models
  • Testing efficacy of anticancer drugs using cancer spheroids
  • Analyzing phenotypic characterization of compound treatments on iPSC-derived hepatocyte spheroids
  • Assessing drug effects on cardiomyocyte physiology using human iPSC-derived cardiac spheroids

About the presenters


Grischa Chandy, Senior Product Marketing and Applications Manager | Molecular Devices

Grischa Chandy is Senior Product Marketing and Applications Manager for Cellular Imaging at Molecular Devices, LLC.  Grischa’s scientific background is in cell biology, physiology and biophysics.  He has used and developed imaging techniques and technologies throughout his career starting with his doctoral work at U.C. Irvine, his postdoc at U.C. Berkeley as well as Research Scientist position at Stanford University.

Grischa has been with Molecular Devices for 10 years, driving launches of the ImageXpress Micro –XL and ImageXpress Micro-XLS systems, MetaXpress Software versions 3 onwards and most recently the launch of the ImageXpress Micro Confocal system and ImageXpress Micro 4 system.


Oksana Sirenko, Research Scientist, Marketing | Molecular Devices

Oksana Sirenko earned her Ph.D. in Biochemistry from the Biochemistry Research Institute, Academy of Sciences in Ukraine. For over 15 years, she has worked as a Research Scientist in cell-based assay development, drug discovery and drug development in several pharma and biotech companies, including Novartis, Bayer, and Fibrogen. At Molecular Devices she is focused on assay development using high-content imaging systems and other instruments to develop methods for cell-based disease modelling and toxicity research. 

Mike Hancock, Senior Technical Application Scientist | Cellular Dynamics International

Mike Hancock earned his Ph.D. in Biochemistry from the Medical College of Wisconsin. For over 13 years, he has worked as a cell-based assay development scientist in pharma and biotech. In his current role, Mike is a Senior Technical Application Scientist at Cellular Dynamics International where he helps to characterize and develop ways to utilize the growing palette of human iPSC-derived cell types, including: astrocytes, cardiomyocytes, hepatocytes, macrophages, neurons, and skeletal myoblasts.

Mark Rothenberg, Manager Scientific Training and Education | Corning Life Sciences

Mark Rothenberg graduated from Emory University with his PhD in Cell and Developmental Biology. Over the past 25 years Mark has held positions in both Academia and industry where he has developed an expertise in the areas of assay development, cell culture, and cell culture scale-up.  Mark has been with Corning Life Sciences for eight and a half years. Prior to his current position as Manager Scientific Training and Education he worked and led the applications team.

About the companies

At Molecular Devices, we enable our customers to unravel the complexity of biological systems. Our innovative analytical solutions for cell and protein biology enable our customers to see more, do more, and know more, and to answer life's most important questions. We are one of the world’s leading providers of high-performance bioanalytical measurement solutions for life science research, pharmaceutical and biotherapeutic development. With over 130,000 placements in laboratories around the world, our instruments have catalyzed brilliant scientific research described in over 25,000 peer reviewed publications. Included within a broad product portfolio are platforms for high-throughput screening, genomic and cellular analysis, colony selection and microplate detection. These leading-edge products empower scientists to improve productivity and effectiveness, ultimately accelerating research and the discovery of new therapeutics. Visit us at www.moleculardevices.com

Cellular Dynamics International (CDI), a FUJIFILM company, is a leading developer and manufacturer of human cells used in drug discovery, toxicity testing, stem cell banking, and cell therapy development. The Company partners with innovators from around the world to combine biologically relevant human cells with the newest technologies to drive advancements in medicine and healthier living. CDI’s technology offers the potential to create induced pluripotent stem cells (iPSCs) and differentiated tissue-specific cells from any individual, starting with a standard blood draw. Our proprietary manufacturing system produces billions of cells, resulting in inventoried iCell® products and donor-specific MyCell®Products in the quantity, quality, purity, and reproducibility required for drug and cell therapy development. With over 100 peer-reviewed papers on iCell and MyCell products and services, active implementation and model development partnerships within Industry and Academia, regenerative medicine initiatives spanning several organ systems, and a global distribution and support network, Cellular Dynamics has established itself as a world-leader in advancing and fulfilling the promise of stem cell-based technologies. For more information please visit www.cellulardynamics.com and follow us on Twitter @CellDynamics

Corning strives to develop new products and improve efficiencies for researchers working with a variety of cell types in areas like cancer research, drug screening and lab automation. Learn more about Corning’s novel 3D Cell culture tools for oncology assays and high throughput screening by visiting www.corning.com/lifesciences.