A major challenge in many electrophysiology laboratories is the elimination of 50 Hz or 60 Hz line-frequency noise and the associated high-frequency harmonics. Also called electrical hum, these interfering signals stem from the alternating current (AC) of the electrical mains, and are delivered to the lab via power sockets and outlets. The Axon team at Molecular Devices have created an effective, efficient solution for this problem with the Axon™ Digidata® 1550A Low-Noise Data Acquisition System plus HumSilencer™ Adaptive Noise Cancellation. The built-in HumSilencer feature eliminates line-frequency noise with a single click and in less than one second, saving time and facilitating all electrophysiology applications. See the power and easy implementation of the HumSilencer feature in this video.