This video highlights how scientists can streamline workflows—from iPSC culture to brain organoid passaging and analysis—using intelligent scheduling, real-time monitoring, machine learning–based decision-making, and a new rocking incubator that ensures consistent nutrient delivery to support healthy organoid growth. Scalable and reproducible, the CellXpress.ai® Automated Cell Culture System is helping scientists accelerate neuroscience research.

https://vids.moleculardevices.com/watch/4oMgWVWge9oEPG9zP13BUn

Transcript

Hello! My name is Sandra Grund-Gröschke, and I am a 3D Application Scientist here at Molecular Devices. Today, I’m excited to show you how automation is transforming brain organoid research with the CellXpress.ai Automated Cell Culture System—a powerful tool that’s helping scientists scale up their work with greater precision and efficiency.

The benefit of using organoids in drug discovery is well-established and research is advancing rapidly to support these powerful models. Brain organoids are three-dimensional, miniaturized models of parts of the human brain. They resemble human tissue and are a great tool to study human brain development and diseases. This innovative approach is transforming our understanding of the brain."

However, the culture process for these organoids is manual, time-consuming, and requires precise and consistent work over a long period, often exceeding 100 days. This is where the CellXpress.ai system comes into play, offering a groundbreaking solution."

The CellXpress.ai system acts as an intelligent lab assistant, automating the entire process from cultivation of the induced pluripotent stem cells up to seeding and differentiation of complex brain organoids. During the whole process the culture will be constantly monitored. This allows researchers to focus on the broader aspects of their work while the system handles the mundane tasks.

The CellXpress.ai Automated Cell Culture System leverages AI-powered machine learning and advanced imaging to monitor brain organoids in real time. It detects even the most subtle morphological or environmental changes and can respond by excluding wells from further feeding events and inform the user of experimental progress when required.

With continuous, around-the-clock automation, the CellXpress.ai system minimizes human error, improves consistency, and frees up researchers to focus on high-impact scientific questions instead of routine maintenance. The CellXpress.ai system can be equipped with a rocking incubator, which allows to keep the brain organoids in motion. Its modular, mix-and-match rack design allows multiple cell lines—from iPSCs to brain organoids—to be cultured simultaneously and in the same incubator. This unmatched flexibility is ideal for labs managing diverse models or experimental conditions.

The CellXpress.ai system is already making a significant impact in laboratories worldwide. Its intuitive, AI-driven platform and unique rocking incubator empowers researchers to push boundaries with confidence. Whether studying neurological disorders or screening new drug candidates, the system supports a wide range of applications—making complex, human-relevant research more accessible than ever.