Multiplexed assays for neurotoxicity evaluation using neural 3D cell models

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Multiplexed automated assays for neurotoxicity evaluation using induced pluripotent stem cell-derived neural 3D cell models

This poster presentation demonstrates how an iPSC-derived 3D neurospheroid assay platform can be used to assess the neuroactive and neurotoxic potential of drugs and environmental toxicants.

• Evaluate the functional responses from known neuromodulators, neuroactive, and neurotoxic drugs using the FLIPR® Penta system and ScreenWorks Peak Pro 2 analysis software
• Detect and characterize multiparametric readouts of oscillation peaks
• Assess compound effects on morphology and viability of neural spheroids using the ImageXpress® Micro Confocal system