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Disease modeling methods with cancer patient-derived organoids

Here, we demonstrate the capabilities of a novel semi-automated tumoroid assay system that performs complex protocols with 3D cell models in an incubator environment. Patient-derived tumoroids derived from primary tumors were assayed for compound response using high resolution confocal imaging of cell surface markers and viability stained for Live/Dead. The ability to analyze tumoroids and organoids in situ in order to capture toxicity information and perform functional assays shows great promise for disease modeling.

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