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Water immersion objectives for automated high-content imaging to improve precision and quality of complex biological assays

Water Immersion Objectives in Biological Assays

Overview

The purpose of these studies was to determine if water immersion objectives, used to improve image quality in complex biological assays, could be used in a high-throughput environment.

Complex event analysis for neurotoxic profiling of compound effects on human iPSC-derived neural spheroid 3D cultures

Overview

We describe a method for the complex analysis of calcium oscillations using the FLIPR® Penta High-Throughput Cellular Screening System that allows detection and multi-parametric characterization of oscillation peaks. ScreenWorks® Peak Pro 2 analysis software analyzes calcium oscillation rate, peak width and amplitude, characterization of secondary peaks, waveform irregularities, and several other read-outs.

 
Water Immersion Objectives in Biological Assays

High-throughput assessment of compound-induced pro-arrhythmic effects in human iPSC-derived cardiomyocytes

High throughput assessment

Overview

Development of biologically relevant and predictive cell-based assays for compound screening and toxicity assessment is a major challenge in drug discovery. The focus of this study was to establish high-throughput, compatible cardiotoxicity assays using human induced pluripotent stem cell (iPSC)-derived cardiomyocytes.

Video presentation coming soon...

 

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ImageXpress® Micro Confocal System

Capture sharper, crisper 3D cell images with our NEW water immersion objectives

  • Increase in penetration depths dependent on sample
  • Improve z-resolution and optical aberrations
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  • Shorten image acquisition time

SpectraMax® iD5 Multi-ModeMicroplate Reader

Multi-user microplate reader with a large touchscreen and NFC functionality

  • Measure absorbance, fluorescence, luminescence, TRF, & FP
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