Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is a primary challenge in drug discovery. The integration of three-dimensional (3D) assay models is becoming more widespread to drive translational biology. Specifically, 3D cultures offer the advantage of closely recapitulating aspects of human tissues including the architecture, cell organization, cell-cell and cell-matrix interactions, and more physiologically-relevant diffusion characteristics.
This ebook highlights the 3D cell culture imaging and analysis advantage and includes a few 3D cell model applications as well as tips and techniques for optimizing your 3D assay workflow.
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![]() ImageXpress PicoAutomated Cell Imaging System ![]() |
![]() ImageXpress NanoAutomated Imaging System ![]() |
![]() ImageXpress Micro 4High-Content Imaging System ![]() |
![]() ImageXpress Micro
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CAMERA |
5 megaPixel CMOS |
4.7 megaPixel CMOS |
>4 megaPixel CMOS |
>4 megaPixel CMOS |
FIELD OF VIEW 10X |
1.93 mm2 |
1.85 mm2 |
1.96 mm2 |
1.96 mm2 |
OBJECTIVES |
4x-63x Air |
2x-60x Air |
Air (1x-100x), Oil (40x, 60x, 100x) |
Air (1x-100x), |
FILTERS CHANGER |
5 position filter cube changer |
5 position filter cube changer |
5 position filter cube changer |
8 position emission wheel and |
AUTOFOCUS |
LED+ image autofocus |
Laser+image autofocus |
Laser+image autofocus |
Laser+image autofocus |
PLATES |
Up to 384-well plates |
Up to 1536-well plates |
Up to 1536-well plates |
Up to 1536-well plates |
TEMPERATURE CONTROL |
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