Iowa State University uses the ImageXpress Widefield system to develop strategies to rescue and repair of damaged nervous systems

"At the end of four days of culture, time-lapse imaging would generate about 275,000 images. "

Iowa State University,Department of Genetics, Development, and Cell Biology

Donald Sakaguchi, PhD, Professor

ImageXpress Micro XLS Widefield High-Content Analysis System

The Challenge

Research in the Sakaguchi Lab at Iowa State University focuses on experimental strategies for the rescue and repair of the damaged nervous system using stem cell approaches. Specifically, the lab is developing a multifunctional biodegradable conduit that can be seeded with adult stem cells to facilitate nerve regeneration. In addition, they are transplanting stem cells engineered as delivery vehicles for therapeutic factors to treat blinding ocular diseases such as glaucoma.

Iowa State Universtiy uses ImageXpress Widefield System

Iowa State University

The Solution

To ensure that cells to be transplanted are healthy and normal, the ImageXpress Micro System is used to analyze different cell lines, cell populations, cell differentiation properties in a high throughput fashion. The integrated software package further allows multiple cell types, substrates, cell behaviors to be characterized at once, reducing variability across experiments.

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