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Molecular Devices High Content Screening Computer Specifications

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Computer and Server Specifications for Offline Analysis with the AcuityXpress™ and MetaXpress® Software, MDCStore™ Data Management Solution, and MetaXpress® PowerCore™ Software

9500‐6185 Q
April 2013

Introduction

This document is provided to customers who have purchased Molecular Devices, LLC (“Molecular Devices”) equipment, software, reagents, and consumables to use in the operation of such Molecular Devices equipment, software, reagents, and consumables. This document is copyright protected and any reproduction of this document, in whole or any part, is strictly prohibited, except as Molecular Devices may authorize in writing.

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Contents

IT Infrastructure and Support, Database Support................................................................................................ 4
MetaXpress and AcuityXpress Offline Analysis Clients (v2.0 and later) ....................................................................5
MDCStore Database Solution (MDCStore Database v2.0 and later and MDC File Server v1.0 and later) ............... 7
Database Requirements ............................................................................................................................................7
Minimum Basic Server Specifications........................................................................................................................7
Recommended Specifications for Database Server (Minimum for MetaXpress PowerCore Software)....................8
Image Storage Locations............................................................................................................................................8
MDC File Server, File Server Manager  (available only as a 32 bit application).........................................................8
UNC paths..................................................................................................................................................................8
MetaXpress PowerCore Clients and Servers........................................................................................................ 9

IT Infrastructure and Support, Database Support

The installation of the ImageXpress® instrument and the instrument workstation is performed by Molecular Devices service engineers. The installation and maintenance of all software on other clients and servers, including the database software, such as Oracle or Microsoft SQL Server should be performed by information technology professionals, such as a Database Administrator (DBA) to manage and optimize the Molecular Devices software and database for your facility. Please consult with Molecular Devices support for guidance on the installation process and help from professional services.

High Content Screening (HCS) generates vast amounts of data. For example, one ImageXpress instrument can generate 250 GB to 500 GB of data each day. See Figure 1:  Example Configuration for Core or Medium Throughput Facility to represent 2 instruments, using multiple screens per year, generating 100 GB per day, 5 days per week (500 GB per week or ~10 TB to 20 TB per year) and requiring multiple databases and file storage locations. This configuration is given as an example. Your throughput might be different and you might not be using the MetaXpress PowerCore technology altering your specific configuration.

To ensure the full capability of data transfer, we highly recommend gigabit‐capable firewalls, routers, and cabling (cat 6) for use with all applicable computers. Unreliable, non-dedicated networks and communication across sub- networks greatly affects the performance of data transfer. Consult with the Molecular Devices support team to determine the optimal set‐up for your infrastructure.

Figure 1: Example Configuration for Core or Medium Throughput Facility

MetaXpress and AcuityXpress Offline Analysis Clients (v2.0 and later)

Table 1: Computer Specifications for Offline Analysis Clients

Table 1: Computer Specifications for Offline Analysis Clients

  Minimum Recommended
Computing Hardware Windows‐compatible, 32-bit, 2 CPU cores1 Windows‐compatible, 64-bit,  4 CPU cores or more1
Operating System (OS)2 Microsoft Windows XP Professional2 Microsoft Windows 7, 64-bit Professional or Ultimate2
RAM 2 GB
4 GB for the MetaXpress
Custom Module Editor
8 GB or more
Hard Disk Space for Client Programs 10 GB 10 GB or more
Hard Disk Space for Eventual Database and Image Storage (For demo versions of the clients, the same computer can run both client and server software) 4 GB of hard disk space for the MDCStore Database. The required image storage is a function of the number of images stored: allocate ~5 GB to 10 GB for a 384-well plate Molecular Devices recommends that you run the client and server software on separate computers.
Graphic Display 32-bit graphics display, 128 MB video RAM with support for DirectX 9.0 or later versions 32-bit graphics display, 256 MB or more video RAM (such as, a 512 MB GeForce Video Card) with support for DirectX 9.0 or later versions, dual monitor option
USB Ports for Software Security Keys 2 USB ports 4 or more integrated USB 2.0 ports
CD/DVD Drives 1 DVD drive 1 DVD drive
Network Card 10/100/1000 Mbps (maximum throughput use 1000 Mbps or higher dedicated LAN)

1 See Table 3: MetaXpress PowerCore Servers and Clients
2 See Table 2: Supported Operating System for MetaXpress and AcuityXpress Offline Analysis Clients

Table 2: Supported Operating System for MetaXpress and AcuityXpress Offline Analysis Clients

Table 2: Supported Operating System for MetaXpress and AcuityXpress Offline Analysis Clients

  AcuityXpress Software MetaXpress Software MetaXpress PowerCore Software
  2.x 2.0 3.0 3.1 4.0 5.x 1.x
Windows XP,
32-bit
X X X X X X X
Windows XP,
64-bit
          X
Windows Server 2003,
32-bit
            X
Windows Server 2003,
64-bit
            X
Windows Vista,
32-bit
X      
Windows Vista,
64-bit
     
Windows Server 2008,
32-bit
        X
Windows Server 2008,
64-bit
        X
Windows 7, Professional or Ultimate only¹,
32-bit
X     X
Windows 7, Professional or Ultimate only¹,
64-bit
    X

1 The software is not supported on Windows 7 Starter, Home Basic, Home Premium, or Enterprise editions.
2 The AcuityXpress Software is installed and runs as a 32-bit application on a 64-bit operating system.
3 MetaImaging Series Administrator and MDCStoreTools need to be running with local administrator privileges. See the Knowledge Base (http://www.moleculardevices.com/support.html) for more information.

Note: If you are creating or editing a module with the MetaXpress Custom Module Editor, Molecular Devices recommends that you use a 64‐bit operating system.

The MDCStore Xchange Service uses your default web browser to create and schedule import and export jobs. The service supports the following web browsers:

  • Microsoft Internet Explorer (version 9 or later)
  • Mozilla FireFox
  • Apple Safari
  • Google Chrome

Note: The MDCStore Xchange Service must be installed on the same sub‐network as your license key.   Molecular Devices recommends that you install the MDCStore Xchange Service on Windows 7, since some image and data conversions are not available in Windows XP.

MDCStore Database Solution (MDCStore Database v2.0 and later and MDC File Server v1.0 and later)

Minimum Basic Specifications provide full functionality.

Recommended Specifications provide guidance for best system performance. However, server specifications depend strongly on the size of the operation. Discuss your server requirements with your computer vendor, your IT department, and Molecular Devices technical support to determine the optimal configuration to fit the size of your organization.

Database Requirements

Molecular Devices recommends installing the database on a server dedicated to the imaging applications. Do not share it with other applications.

  • Microsoft SQL Server 2005 or later, Standard, Enterprise, and Datacenter editions. A license of Microsoft SQL Server 2012 can be included with the purchase of Molecular Devices acquisition systems.
    • The minimum requirement for compatibility with the MetaXpress PowerCore Software is Microsoft SQL 2005.
  • Oracle 10g or Oracle 11g (11.1 or 11.2) if not using Microsoft SQL Server

Minimum Basic Server Specifications

In minimum recommendations, the same computer can run both the MDCStore Database and the file server together.

  • IBM-compatible 32‐bit computer with a 2 GHz or faster Intel® Pentium 4 or Xeon® processor
  • Windows Server 2003 operating system
  • 4 GB system memory (RAM)
  • 100 GB available hard disk space for database
  • Greater than 1 TB for local image storage (1 TB SATA hard drive)
  • 2 USB ports for software security keys

Recommended Specifications for Database Server
(Minimum for MetaXpress PowerCore Software)

Our recommendation for best performance is to run the MDCStore Database and the FileServer on separate computers. The installation, tuning, and optimization of the database should be performed by a professional Database Administrator. Please consult Molecular Devices for recommendations on the use of outside professional services.

  • IBM-compatible computer with the fastest Intel Core™ multi‐core Processor
  • Operating system supported by database application in use
  • 4 GB RAM or more
  • 1 TB or more available space on an SATA or SCSI Raid 0, 5, or 10 storage sub-system
  • 10/100/1000 Mbps Gigabit network card
  • 2 USB ports for software security keys

Image Storage Locations

Our recommendation for best performance is to run the MDCStore Database and the file locations on separate computers.

MDC File Server, File Server Manager
(available only as a 32 bit application)

* Application needs to run with local administrator privileges

  • IBM-compatible 32‐bit or 64-bit computer with a 2 GHz or faster processor
  • Windows Server 2003 (32-bit or 64-bit ), XP (32-bit or 64-bit ), Vista* (32-bit or 64-bit), or Windows 7* (32-bit or 64-bit ) operating system
  • 1 GB RAM or more
  • 1 TB or more available space on an SATA or SCSI Raid 0, 5, or 10 storage sub-system
  • 2 TB or more available space on an SATA or SCSI Raid 0, 5, or 10 storage sub‐system
  • 10/100/1000 Mbps Gigabit network card

UNC paths

Any Operating System Supporting UNC File Paths

For use with MetaXpress PowerCore Software, the machine providing the UNC path should support multiple simultaneous connections. Microsoft Windows XP and Vista support only 10 connections, and certain versions of Windows 7 support up to 20 connections. The performance of MetaXpress PowerCore Software might be affected with a high number of simultaneous connections.

Note: To check the maximum number of connections, log on with local Administrator rights. Click Start > Run, type cmd, and click OK. Type net config server and check for Maximum Logged On users number. This is the maximum inbound connections.

MetaXpress PowerCore Clients and Servers

For best performance, use separate computers for the MetaXpress PowerCore Server, MetaXpress PowerCore Clients, MDCStore Database and the FileServer.

For the database server, use the Recommended Specifications as opposed to the Minimum Basic Specifications for optimal system performance. See Table 2: Supported Operating System for MetaXpress and AcuityXpress Offline Analysis Clients on page 7.

For the Molecular Devices recommendations of computer specifications to obtain the minimum or best performance with the MetaXpress PowerCore Servers and Clients, see Table 3: MetaXpress PowerCore Servers and Clients on page 10.

For a list of validated MetaXpress PowerCore Server operating systems and MetaXpress PowerCore Client operating systems for each supported database server software (Microsoft SQL Server 2005, Oracle 10g, and Oracle 11g), see Table 4: Validated Configurations for Microsoft SQL and Oracle with the MetaXpress PowerCore Server and/or Client on page 11.

The performance of MetaXpress PowerCore Software and the speed of analysis will be highly dependent on specific settings and infrastructures. Please consult with Molecular Devices to obtain “benchmarking” data on defined configurations.

While MetaXpress PowerCore Software can be configured in a “seti@home” mode with clients throughout the network working in a screensaver mode, this configuration will not provide the maximum performance expected from the MetaXpress PowerCore Software. To take full advantage of the speed of MetaXpress PowerCore Software, Molecular Devices recommends using the dedicated computers for analysis (recommended specifications).

Table 3: MetaXpress PowerCore Servers and Clients

Table 3: MetaXpress PowerCore Servers and Clients

  Minimum Recommended
Computing Hardware Windows-compatible, 32‐bit with a 2.6 GHz or faster Intel Pentium 4 processor Windows-compatible, 64‐bit with the fastest Intel Core multi‐core processor
Processor Cores (Server) 2 cores
  • 1 core for the operating system
  • 1 core for the Server
2 or more cores
  • 1 core for the operating system
  • 1 core for the Server
Processor Cores (Clients) 2 cores
  • 1 core for the operating system
  • 1 core per Client
2 or more cores
  • 1 core for the operating system
  • 1 core per Client
Operating System See Table 4: Validated Configurations for Microsoft SQL and Oracle with the MetaXpress PowerCore Server and/or Client.
For optimal performance, Molecular Devices highly recommends using a Server Operating System to host the MetaXpress PowerCore Server
Note: Windows XP and Vista enforce a limit of 10 connections per computer.   Windows 7 has a limit of 10 or 20 depending on the version.
See Table 4: Validated Configurations for Microsoft SQL and Oracle with the MetaXpress PowerCore Server and/or Client.
Windows Server 2008
Database Server Software See Table 4: Validated Configurations for Microsoft SQL and Oracle with the MetaXpress PowerCore Server and/or Client.
RAM (Server) 512 MB 2 GB or more for 8 distributed processes
4 GB for 16 distributed processes
RAM (Clients) 512 MB per CPU 1 GB or more per CPU
Hard Disk Space for Server and Image Storage 10 GB or more
USB port for Software security key (Server only) 1 open USB port on Server computer

The preference is to use the same Operating System on both the MetaXpress PowerCore Server and Clients

Table 4: Validated Configurations for Microsoft SQL and Oracle with the MetaXpress PowerCore Server and/or Client

Operating System (Microsoft Windows only) Database Database Driver
Windows Server 2003, 32-bit MS SQL 2005
Oracle 10.2.0.1
Oracle 11.1
Oracle 11.2
SQL Server ODBC driver 2000.86.3959.00
Oracle 10g, 32 bit (10.2.0.1 or 10.2.0.3)
Oracle 11g, 32 bit (11.1.0.7)
Oracle 11g, 32 bit (11.2.0.1)
Windows Server 2003, 64-bit MS SQL 2005
Oracle 10.2.0.1
Oracle 11.1
Oracle 11.2
SQL Server ODBC driver 2000.86.3959.00
Oracle 10g, 64 bit (10.2.0.1 or 10.2.0.3)
Oracle 11g, 64 bit (11.1.0.7)
Oracle 11g, 64 bit (11.2.0.1)
Windows XP, 32-bit MS SQL 2005
Oracle 10.2.0.1
Oracle 11.1
Oracle 11.2
SQL Server ODBC driver 2000.85.1132.00
Oracle 10g, 32 bit (10.2.0.1 or 10.2.0.3)
Oracle 11g, 32 bit (11.1.0.7)
Oracle 11g, 32 bit (11.2.0.1)
Windows XP, 64-bit MS SQL 2005
Oracle 10.2.0.1
Oracle 11.1
Oracle 11.2
SQL Server ODBC driver 2000.85.1132.00
Oracle 10g, 32 bit (10.2.0.1 or 10.2.0.3)
Oracle 11g, 32 bit (11.1.0.7)
Oracle 11g, 32 bit (11.2.0.1)
Windows XP, 32-bit MS SQL 2005
Oracle 10.2.0.1
Oracle 11.1
Oracle 11.2
SQL Server ODBC driver 2000.85.1132.00
Oracle 10g, 64 bit (10.2.0.1 or 10.2.0.3)
Oracle 11g, 64 bit (11.1.0.7)
Oracle 11g, 64 bit (11.2.0.1)
Windows Server 2008, 32-bit MS SQL 2005
MS SQL 2012 (R2)
Oracle 11.2
SQL Server ODBC driver 6.00.6002.18005
SQL Server ODBC driver 6.00.6002.18005
Oracle 11g, 32 bit (11.2.0.1)
Windows Server 2008, 64-bit MS SQL 2005 (SP3)
MS SQL 2012
Oracle 11.2
SQL Server ODBC driver 6.00.6002.18005
SQL Server ODBC driver 6.00.6002.18005
Oracle 11g, 64 bit (11.2.0.1)
Windows 7, 32-bit MS SQL 2005 (SP3)
MS SQL 2012
Oracle 11.2
SQL Server ODBC driver 6.01.7601.17514
SQL Server ODBC driver 6.01.7601.17514
Oracle 11g, 64 bit (11.2.0.1)
Windows 7, 64-bit MS SQL 2005 (SP3)
MS SQL 2012
Oracle 11.2
SQL Server ODBC driver 6.01.7600.16385
SQL Server ODBC driver 6.01.7601.17514
Oracle 11g, 64 bit (11.2.0.1)

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