Application Note

Objective quantification of cell migration on the CloneSelect Imager System

  • Rapid scanning to monitor cell migration
  • High quality imaging and label-free detection of living cells using white light

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Background

Cell migration is a key process in normal development, immune function and wound healing. Abnormal cell migration is a feature of conditions such as cardiovascular disease and cancer. The CloneSelect Imager system reveals the in vitro effects of therapeutic candidates and cell culture matrices on cell migration as well as the study of cell-to-cell interactions. Migration application software in CloneSelect Imager enables measurement of cell migration based on objective cell detection.

Method

Image capture and analysis

High quality data generation

CloneSelect Imager – objective, quantitative assessment of cell growth

The CloneSelect™ Imager system utilizes non-invasive, white light imaging to enable rapid, quantitative measurement of cell confluence and generation of growth curves well by well.

Fast results

  • Replace time-consuming manual inspection
  • Make confident, image-driven decisions
  • Obtain consistent results in under three minutes per 96-well plate

For applications including:

  • Rapid confluence measurement
  • Growth curve generation
  • Cell number estimation
  • Verification of monoclonality
  • Colony forming assays
  • Cell migration assays

Key parameters

  • Accepts multi-plate formats from single well to 384 well
  • 4x objective lens
  • Resolution to 1.8 µm
  • Integrated barcode reader
     

Rapid image generation and clear data analysis

ClonePix, CloneSelect, CellReporter are trademarks of Molecular Devices Ltd. All third party trademarks are the property of their respective owners. For a listing of trademark owners, visit www.moleculardevices.com/trademarks

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