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Application Note

A workflow combining single-cell isolation and microplate imaging improves cloning efficiency with higher assurance of clonality

  • Isolate cells efficiently using label-free or fluorescence-based imaging
  • Easily obtain high assurance of monoclonality with direct, image-based documentation of single cells captured pre- and post-cell sorting
  • Improve clonal outgrowth compared to limiting dilution (4X to 8X improvement is typically observed) using a patented single-cell dispensing system
  • Minimize the risk of cross-contamination between samples by using one-way disposable cartridge
  • Efficiently track cell outgrowth over time
  • Quickly generate monoclonality reports readily for submission to regulatory agencies