APPLICATION NOTE
Increase signal detection and optimize colony selection
Register to download your application note today:
To achieve over 5 fold of human IgG protein detection signal enhancement with 1 round of CloneDetect K8495 assay optimization
Utilizing a combination of imaging and robotics, ClonePix System screens for clonality and productivity simultaneously prior to collecting the highest-producing clones in a rapid one-step process. Plus:
- Over 5 fold of signal improvement with 1 round of assay optimization
- Real-time monitoring of therapeutic antibody production in local cell culture environment
- Easy setup and applicable to other cell models and proteins quantification
- 100% hands-free and walk-away solution to complement ClonePix 1-step workflow and improve clone screen efficiency
Learn more about the systems behind the methods
ImageXpress Confocal HT.ai system
Powerful multi-laser light sources, a deep tissue penetrating confocal disk module, water immersion objectives and modern machine learning analysis software
- Ideal for highly-complex cell-based and 3D assays
- Seven-channel high-intensity lasers generating brighter images with higher signal-to-background
- Spinning confocal disk technology for deeper tissue penetration, resulting in sharper images with improved resolution
- Water immersion objectives offering quadruple the signal at lower exposure times for greater sensitivity and image clarity without sacrificing speed
- Optional IN Carta software, leveraging intuitive, modern machine learning
CloneSelect Imager and CloneSelect Imager FL
Verify monoclonality confidently
The all-new CloneSelect Imager FL adds high contrast multichannel fluorescent technology in addition to the standard white light imaging that allows for accurate single-cell detection and proof of monoclonality at day 0. Streamline your workflow with comparative confluence assays to identify and verify gene edits.
- Document evidence of single cells and confluency digitally for auditing and submission to regulatory authorities
- Image cells non invasively at multiple time points to monitor colony formation
- Screen using high resolution white light imaging
- Deliver real-time results with on-the-fly analysis
- Automation and integration ready
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