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CloneSelect Imager FL
Innovative imaging solution for monoclonality assurance and automated confluence
Learn moreSpectraMax Mini Multi-Mode Microplate Reader
Affordable multi-mode microplate reader with best-in-class data analysis software
Learn moreSoftMax Pro GxP Software
The most secure software to achieve full FDA 21 CFR Part 11 compliance
Learn moreStratoMineR Advanced Cloud-Based Analytics
An intuitive and powerful platform for phenotypic profiling
Learn moreCell Painting Assays
A high-content, multiplexed image-based assay used for cytological profiling.
Learn moreWe are advancing discovery in protein and cell biology around the globe
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Continuous Innovation
We provide life science solutions to solve today’s most relevant problems. Our inspiration comes from our customers—we collaborate with them to develop innovative technologies that allow scientists to improve lives.
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Extensive Publication Success
We are proud of our customers’ success of over 230,000+ citations and counting. From microplate readers to imaging systems to software, our wide range of solutions help scientists share their discoveries.
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World-class Service Plans
Comprehensive service plans include validation and preventative maintenance that reduce operating costs and maximize lab productivity.
Research Areas
Drug Discovery and Development
For every drug that makes it to the finish line, another nine don’t succeed. This alarming failure rate can be traced to reliance on 2D cell cultures that don’t closely mimic complex human biology, often leading to inaccurate predictions of a drug’s potential and extended drug development timelines. The drug discovery landscape is shifting, with more scientists centering cell line development, disease models, and high-throughput screening methods around physiologically-relevant 3D cell models. The reason for this is clear: Using cellular model systems in research that closely mimic patient disease states or human organs can bring life-saving therapeutics to market – faster. Our Organoid Innovation Center was envisioned as a lab of the future—a collaborative space where automated cell line development and 3D biology workflows unite, enabling customers and industry partners to scale drug discovery research with a high-throughput screening solution.
Gene Editing (CRISPR/Cas9)
Gene editing is a genetic manipulation in which a living organism’s genomic DNA is deleted, inserted, replaced, or modified. Gene editing is a site-specific targeting to create breaks in DNA through various techniques and does not always involve repair mechanisms. It consists of two techniques – inactivation and correction. Inactivation involves the turning of a target gene, and correction facilitates the repair of the defective gene through a break in the gene. Gene editing has vast potential in a myriad of fields, including drug development, gene surgery, animal models, disease investigation and treatment, food, biofuel, biomaterial synthesis, and others. Though CRISPR, a major gene editing technique, has been extensively used recently, gene editing was first studied in the late 1900s. Since the onset of CRISPR, previously an ambitious application, gene therapy has become the most sought-after application of gene editing. This can be achieved through two approaches, gene addition, which adds to the existing genetic material to make up for faulty or missing genes, and gene editing, which treats diseases by directly modifying the disease-related DNA.
Organoid Innovation Center
The new Organoid Innovation Center at Molecular Devices combines cutting-edge technologies with novel 3D biology methods to address key challenges of scaling complex 3D biology. The collaborative space brings customers and researchers into the lab to test automated workflows for organoid culturing and screening, with guidance from in-house scientists. An end-to-end solution standardizes the organoid development process with cell culture, treatment, and incubation, through to imaging, analysis, and data processing, delivering consistent, unbiased, and biologically-relevant results at scale.
Food & Beverage
To ensure quality, authenticity and safety, manufacturers of foods and beverages need to perform a wide range of tests on their products. Many of these tests are based around ELISA, which are used in areas as diverse as checking for the presence of bacterial endotoxins, mycotoxins, various allergens, growth promoter hormones and antibiotics, and for meat species identification. Other absorbance tests can also be used to quantify levels of substances within foods – such as sugars, phenols, and acids. Microplate readers are widely used in research, drug discovery, bioassay validation, quality control, and manufacturing processes in the pharmaceutical, biotech, food and beverage, and academic industries. They provide rapid and sensitive measurements of a variety of analytes across a wide range of concentrations for a wide range of assays including ELISAs, microbial growth, detection of key compounds and contaminants, and protein quantitation.
Cancer Research Solutions
Cancer involves changes which enable cells to grow and divide without respect to normal limits, to invade and destroy adjacent tissues, and ultimately to metastasize to distant sites in the body. Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about our high-content imaging systems and analysis software solution that facilitate cancer research using biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.
3D Cell Models
Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is a primary challenge in drug discovery. The integration of three-dimensional (3D) assay models is becoming more widespread to drive translational biology. Higher complexity cell models have gained popularity because they better mimic in vivo environments and responses to drug treatment. Specifically, 3D cell cultures offer the advantage of closely recapitulating aspects of human tissues including the architecture, cell organization, cell-cell and cell-matrix interactions, and more physiologically-relevant diffusion characteristics. Utilization of 3D cellular assays adds value to research and screening campaigns, spanning the translational gap between 2D cell cultures and whole-animal models. By reproducing important parameters of the in vivo environment, 3D models can provide unique insight into the behavior of stem cells and developing tissues in vitro.
Stem Cell Research
Stem cells provide researchers with new opportunities to study targets and pathways that are more relevant to disease processes. They offer a more realistic model to identify and confirm new drug targets and generate pharmacology and toxicology data earlier, with stronger translation to the clinical setting. Additionally, the application of stem cells in drug development creates a new path to personalized medicine, while at the same time reducing, or even potentially replacing, animal testing. Induced pluripotent stem cell-derived (iPSC-derived) cells enable researchers to study primary cells without the limitations traditionally encountered in obtaining such cells.
Cell Line Development
Stable cell lines are widely used in a number of important applications including biologics (e.g. recombinant protein and monoclonal antibody) production, drug screening, and gene functional studies. The process of developing stable cell lines often starts with transfecting selected host cells, typically CHO or HEK 293 cells, with desired plasmids. After transfection, researchers then screen and quantify high-expressing clones. Once these high producers are identified, the cell lines and/or the proteins produced by the cells are validated. The manual screening methods traditionally used for cell line development are time-consuming and labor-intensive, creating a great demand for high throughput, automated solutions for such efforts. The general workflow below helps identify the systems that can aid in your research.
York University uses Axon Patch-Clamp instruments to investigate the roles of pannexin channels in epilepsy
Case studyInscripta enables scientists to perform digital genome editing…
Case studyResearchers gain new insights into immune response during pediatric respiratory infections using the ImageXpress Pico system
Case studyBioneer use the ImageXpress Micro Confocal for high-throughput imaging of 3D disease models
Case studyETAP Lab use the SpectraMax i3x to advance neurodegenerative disease research
Case study