Comparison of Microplate Readers with Fluorescence Detection

SpectraMax M Series Multi-Mode Microplate Readers Gemini EM Microplate Reader Gemini XPS Microplate Reader FLIPR Tetra High Throughput Cellular Screening System FlexStation 3 Multi-Mode Microplate Reader
Fluorescence
Absorbance
Luminescence+
Time-resolved fluorescence (TRF)+
HTRF Certified+
Fluorescence Polarization+
Wavelength rangeFL 250 - 850, Abs 200 - 1000FL 250 - 850 ex, Abs 360-850 emFL 250 - 850 ex, 250 - 850 emLEDs available in 360-626 nm range, Emission filters available in 400-706 nm rangeFL 250 - 850 ex, 250-850 em; Abs 200-1000
Bandwidth9/9 or 9/15+9/99/9Variable9/15
Tunable wavelength selection/ monochromator
Endpoint
Kinetic
Spectral scanning
Well scanning
Reading speed (sec)15-17+1515117
Microplate formats6-3846-3846-38496, 384, 15366-384**
Integrated multi-channel pipettor***
Temperature control
Top reading
Bottom reading+
Cuvette port
Validation tools
Robotics / automation

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* Secondary modes
**  96- and 384-well with pipetting
*** 8- and 16-channel pipettor
+ Varies by model