Downloadable Literature
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Publications
- A place for high-throughput electrophysiology in cardiac safety: screening hERG cell lines and novel compounds with the IonWorks HT system. J Biomol Screen, 10(8): p. 832-40. (2006).
- A quantitative assessment of hERG liability as a function of lipophilicity. Bioorg Med Chem Lett, 17(6): p. 1759-64 (2007)
- A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
- Balasubramanian B, Imredy JP, Kim D, Penniman J, Lagrutta A, Salata JJ (2009): Optimization of Ca(v)1.2 screening with an automated planar patch clamp platform. J Pharmacol Toxicol Methods 59(2):62-72
- Castle N, Printzenhoff D, Zellmer S, Antonio B, Wickenden A, Silvia C (2009): Sodium channel inhibitor drug discovery using automated high throughput electrophysiology platforms. Comb Chem High Throughput Screen. 12(1):107-22.
- Dubin AE, Nasser N, Rohrbacher J, Hermans AN, Marrannes R, Grantham C, Van Rossem K, Cik M, Chaplan SR, Gallacher D, Xu J, Guia A, Byrne NG, Mathes C (2005): Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp. J Biomol Screen 10(2):168-81
- FLIPR® and FlexStation Bibliography
- Guo L, Guthrie H (2005): Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation. J Pharmacol Toxicol Methods 52(1):123-35
- High Throughput Ion-Channel Pharmacology: Planar-Array-Based Voltage Clamp. Assay and Drug Dev. Technologies 1(1-2):127-135. (2003)
- Imaging and Electrophysiology
- IonWorks HT: A New High-Throughput Electrophysiology Measurement Platform. J Biomol Screen, 8(1):54-60 (2003)
- Limberis JT, Su Z, Cox BF, Gintant GA, Martin RL (2006): Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels. Clin Exp Pharmacol Physiol 33(11):1059-65
- Ly JQ, Shyy G, Misner DL (2007): Assessing hERG Channel Inhibition Using PatchXpress. Clin Lab Med 27(1):201-8
- Novel 384-Well Population Patch Clamp Electrophysiology Assays for Ca2+ Activated K+ channels, J of Biomol Screen 12(1):50-60 (2007)
- Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT. J Pharmacol Toxicol Methods, 54(2): p. 189-99. (2006).
- Population patch clamp electrophysiology: a breakthrough technology for ion channel screening. Molecular Biosystems (2007)
- Population Patch Clamp Improves Data Consistency and Success Rates in the Measurement of Ionic Currents, J of Biomol Screen 11(5):488-496 (2006)
- Randall A, McNaughton N, Green P (2006): Properties of voltage-gated Na+ channels in the human rhabdomyosarcoma cell-line SJ-RH30: Conventional and automated patch clamp analysis. Pharmacol Res 54(2):118-128
- ScreenWorks PlateLoader 2.0
- Tao H, Guia A, Xie B, Santa-Ana D, Manalo G, Xu J, Ghetti A (2006): Efficient Characterization of Use-Dependent Ion Channel Blockers by Real-Time Monitoring of Channel State. Assay Drug Dev Technol 4(1):57-64
- The Axon CNS Guide, 2nd edition
- The Axon CNS Guide, 3rd Edition
- Trepakova ES, Malik MG, Imredy JP, Penniman JR, Dech SJ, Salata JJ (2007): Application of PatchXpress Planar Patch Clamp Technology to the Screening of New Drug Candidates for Cardiac KCNQ1/KCNE1 (I Ks) Activity. Assay Drug Dev Technol 5(5):617-628
- Validation of high throughput screening assays against three subtypes of Ca(v)3 T-type channels using molecular and pharmacologic approaches. Assay Drug Dev Technol, 5(2): p. 191-203 (2007)
- Wible BA, Kuryshev YA, Smith SS, Liu Z, Brown AB (2008): An Ion Channel Library for Drug Discovery and Safety Screening on Automated Platforms. Assay Drug Dev Technol 6(6). [Epub ahead of print]
- Zeng H, Penniman JR, Kinose F, Kim D, Trepakova ES, Malik MG, Dech SJ, Balasubramanian B, Salata JJ (2008): Improved Throughput of PatchXpress hERG Assay Using Intracellular Potassium Fluoride. Assay Drug Dev Technol 6(2):235-241
Tools
Customer Success Stories
Protocols
Webinar
AcuityXpress 2.0 Demonstration Program
Videos & Images
Brochures
FAQ
Application Notes
- A Novel Process for Gene Expression Profiling of Rat and
Mouse Tissues from Formalin-Fixed Paraffin-Embedded
Sections Using Microarrays
- Analyzing Spontaneous Synaptic Function (Drosophila mutant) in Clampfit
- Arcturus® Microdissection Systems: Optimized Protocol for Laser Microdissection of Living In Vitro Cells
- Assessing Slide Flatness
- Automating Microphysiometry Assays for Antagonists Using the Cytosampler Automated Delivery System
- Automation of Microphysiometry Assays Using the Cytosampler Automated Delivery System
- Biological Relevance of GenePix Results
- Characterization of the Functional Activity of C-C and CXC Human Chemokine Receptors Using the Cytosensor Microphysiometer System
- Cholecystokinin Receptors (CCK): Molecular and Pharmacological Characterization of the Human CCKB Receptor
- Comparison of FLIPR andFlexStation for Calcium Mobilization Assays
- Comparison of the Calcium-Sensitive Dyes Fluo-3 and Fluo-4 Used with the FLIPR Fluorometric Imaging Plate Reader System
- Conducting ligand-gated ion channel (LGIC) studies on the PatchXpress 7000A system
- Configuration and optimization of the IMAP Progressive Binding System (IMAP Application Note #1)
- DataXpress Scripting Reference
- Determination of Ki and Km values in IMAP Assays (Application Note #3)
- Developing calibration curves for IMAP (Application Note #4)
- Differential Gene Expression Analysis of Pure Cell Populations from Frozen Uterine Tissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays
- Ethacrynic Acid Potentiates Chlorambucil Cytotoxicity on HT-29 Cells: Early Detection Using the Cytosensor Microphysiometer System
- Evaluating Apoptosis Using the Cytosensor Microphysiometer System
- Evaluating Bradykinin Receptors Using the Cytosensor Microphysiometer System
- Evaluating Dopaminergic Receptors Using the Cytosensor Microphysiometer System
- Evaluating EGF, TGF-a, and Heregulin (HER) Using the Cytosensor Microphysiometer System
- Evaluating Endothelin Receptors Using the Cytosensor Microphysiometer System
- Evaluating Fibroblast Growth Factor (FGF) Using the Cytosensor Microphysiometer System
- Evaluating Human Neutrophils Using the Cytosensor Microphysiometer System
- Evaluating Human µ-Opioid Receptors Using the Cytosensor Microphysiometer System
- Evaluating Interferon-Gamma (IFNg) Using the Cytosensor Microphysiometer System
- Evaluating Interleukin 1 (IL-1) Using the Cytosensor Microphysiometer System
- Evaluating Interleukin 2 (IL-2) Using the Cytosensor Microphysiometer System
- Evaluating Interleukin 3 (IL-3) Using the Cytosensor Microphysiometer System
- Evaluating Muscarinic Receptors Using the Cytosensor Microphysiometer System
- Evaluating Neurotrophic Factors Using the Cytosensor Microphysiometer System
- Evaluating Platelet-derived Growth Factor (PDGF) Using the Cytosensor Microphysiometer System
- Evaluating Receptor Desensitization Using the Cytosensor Microphysiometer System
- Evaluating the Metabolic Response of Mycobacterium tuberculosis to Antibiotics Using the Cytosensor Microphysiometer System
- Evaluating the Stimulation of T Cell Clones and Mixed Populations of T Cells and Antigen-presenting Cells (APCs) Using the Cytosensor Microphysiometer System
- Evaluating the Vascular Endothelial Growth Factor (VEGF) Using the Cytosensor Microphysiometer System
- Evaluation of Neuronal nAChR Using the Cytosensor Microphysiometer System
- Excitatory Amino Acids (Ionotropic--Ligand-gated Ion Channel). Effects of Excitotoxin Exposure on Metabolic Rate of Primary Hippocampal Cultures: Application of Silicon Microphysiometry to Neurobiology
- FLIPR Calcium 3 Assay Kit - An Optimal No-Wash Fluorescence Calcium Indicator Reagent for Non-Optimal Calcium Responses
- FLIPR Membrane Potential Red and Blue Assay Kits on FLIPRTETRA: NaV1.5 sodium channel modulation assay optimization
- FLIPR Tetra and Voltage Sensor Probes: Ratiometric Determination of Barium Chloride-Induced Changes in Inward Rectifying Potassium Channels (Kir) in Rat Basophilic Leukemia Cells
- FLIPR Tetra Fluorometric Imaging Plate Reader and FLIPR Calcium Assay Kit: Comparison of Intracellular Calcium Measurements in 96-, 384- and 1536-Well Formats
- FLIPRTETRA Fluorometric Imaging Plate Reader and FLIPR Calcium Assay Kit: comparison of intracellular calcium measurements in 96-, 384- and 1536-well formats
- GenePix 4000B PMT Adjustment
- GenePix 4000B SNR and PMT Gain Setting
- GenePix 4100A Choosing Emission Filters
- Generating Shading Correction files in MetaXpress for the ImageXpress 5000A
- Genomic Analysis of Intestinal Responses to Gut Flora Altered by Antimicrobials in Human Flora-Associated (HFA) Mice
- Gq-coupled Receptor Assays Using FLEXstation
- Guide to Microarray Analysis
- High-content screening of GPCR activation with
MetaXpress™, AcuityXpress™ and the Transfluor® assay system
- Homogeneous, Chemiluminescence-Based Assays for Receptor Binding, Cellular cAMP, Tyrosine Kinase and Caspase-3 Using the CLIPR Chemiluminescence Imaging Plate Reader
- IMAP: Detection and Quantification of Kinase Inhibitors (Application Note #2)
- Initial Studies of the Effects of Toxic Agents on Hepatocytes Using the Cytosensor Microphysiometer System
- IonWorks HT Application Note 01: Kv1.5 potassium channel assay
- IonWorks HT Application Note 02: hERG safety screening assay
- IonWorks HT Application Note 03: Nav1.5 sodium channel assay
- IonWorks HT Application Note 04: Rapid hit confirmation and early hERG liability testing
- IonWorks Quattro Application Note 01: Optimal assay conditions for hERG pharmacology studies
- IonWorks Quattro Application Note 02: Parallel resistance calculator-Good Data Example(Excel Spreadsheet)
- IonWorks Quattro Application Note 02: Parallel resistance calculator-Poor Data Example (Excel Spreadsheet)
- IonWorks Quattro Application Note 02: Parallel resistance calculator: seal resistance distributions and the transfer of assays from single-hole to population PatchPlate substrates
- IonWorks Quattro Application Note 03: IonWorks software version 2 broadens the experimental repertoire of the IonWorks HT and IonWorks Quattro systems
- IonWorks Quattro Application Note 04: Primary screen of a directed compound library against Nav1.5 channels using Population Patch Clamp technology
- Isolation of Living In Vitro Cells Using the ArcturusXT LCM Instrument
- Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons
- Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions
- Laser Capture Microdissection of Cells Labeled with Enhanced Green Fluorescent Protein
- Laser Capture Microdissection of muscle fiber populations and expression analysis by RT-PCR
- Liquid Junction Potential Corrections
- Making GenePix Array List (GAL) Files
- Measuring Intracellular Calcium With the FLIPR I and FLIPR 384 Fluorometric Imaging Plate Reader Systems
- Measuring Intracellular Calcium with the FLIPR Calcium Assay Kit on Fluorometric Imaging Plate Reader Systems
- Measuring Intracellular pH With the FLIPR I and FLIPR 384 Fluorometric Imaging Plate Reader Systems
- Measuring Membrane Potential Using DiBAC With the FLIPR I and FLIPR 384 Fluorometric Imaging Plate Reader Systems
- Measuring Membrane Potential using the FLIPR Membrane Potential Assay Kit on FLIPR Systems
- Measuring Multiple Receptor Responses on a Single Cell Type Using the Cytosensor Microphysiometer System
- Microgenomic Expression Profiling
- Monitoring Cellular cAMP Activity Using High Efficiency Fluorescence Polarization (HEFP)
- Monitoring of Mitochondrial Membrane Polarization Change in Live Cells Using JC-1 Dye
- Monitoring Receptor-Mediated Changes in [Ca2+] Using Single-Wavelength and Dual-Wavelength
Indicators on the FlexStation™ Workstation
- Multiplexing with IMAP (Application Note #5)
- Optimized Isolation of Live Plant Tissue using Laser Microdissection for use in Gene Expression Analysis
- Paradise® Reagent System
Quick Reference Card
- Performance Evaluation of Various Imagers for UltraHTS
- PKCe is Involved in Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signal Transduction: Evidence from Microphysiometry and Antisense Oligonucleotide Experiments
- Rapid Microbial Responses to Cell-Affecting Agents Measured with the Cytosensor Microphysiometer System
- Recording of Icrac in RBL-1 cells on the PatchXpress 7000A Automated Patch Clamp System
- Regulation of the Activity of a Na+/H+ Antiporter in Schizosaccharomyces pombe Determined with the Cytosensor Microphysiometer System
- Scripting in GenePix Pro
- Setting up a kinase profiler with IMAP (IMAP Application Note #6)
- Stimulating Peripheral Blood T Cells with Anti-CD3 and Anti-CD28 Results in Sustained Increases in Extracellular Acidification Rate
- Target Receptor Discovery and Characterization using the Cytosensor Microphysiometer System
- The Use of Net-Charge Analysis for the Study of Ion Channel Pharmacology
- TR-FRET Detection with IMAP (IMAP Application Note #7)
- Use of a Single Assay System for Assessment of Antagonist Activity for a Wide Variety of receptors
- Use of the Cytosensor Microphysiometer System to Identify and Characterize Peptide Agonists for the Antigen Receptors (sIgR) on B-lymphoma Cells.
- Using the Cytosensor Microphysiometer for Receptor Pharmacology: Determining Agonist Profiles
- Using the Cytosensor Microphysiometer for Receptor Pharmacology: Determining Antagonist Activity
- Using the Cytosensor Microphysiometer System for Signal Transduction: Evaluating the Acidification Response by a Receptor-activated Pathway. The Use of Metabolic Modifiers and Signal Transduction Probes
- Using the Cytosensor Microphysiometer System to Evaluate Transient Transfections of b2-Adrenergic and EGF Receptors
- Using the Cytosensor Microphysiometer System to Study the Receptor Subtype, Species, and Signalling Specificity of Pharmacological Agents
- Using the FLIPR System and the FLIPR Calcium Assay Kit to Develop a High Throughput HEK293/GPCR X Assay
- Veritas microdissection system: optimized protocol for laser microdissection of living in vitro cells
Datasheets and Spec Sheets
Fluorescence Application Notes & Bulletins
Absorbance Application Notes & Bulletins
Luminescence Application Notes & Bulletins
DNA Application Notes
Immunoligand Assay (ILA) Application Notes
Liquid Handling Application Notes & Bulletins
Animation
Declaration of Conformity
Product Inserts
Miscellaneous Documents
2006 Posters & Presentations
Data Analysis Software Review
Licensing Agreement
Demonstration Program
2005 Posters & Presentations
Posters & Presentations
- 1536 Tetra performance-Lab Automation 2009
- A Comparison of FRET and FP Assay Platforms: Z’-LYTE and IMAP
- A fluorescence-based FLIPR® assay for Potassium Channels using a Thallium sensitive probe and MDC’s proprietary masking dye technology.
- A Fluorescence-Based Neurotransmitter Transporter Uptake Assay
- A Novel High-Throughput Assay for Screening Factors with Effects on Neurite Outgrowth
- A Stable, Sensitive Fluorescence-based Method for Detecting cAMP
- A washer for 1536 well plates : the Aquamax DW4?
- Adaptation of a high sensitivity 384 well solid phase assay platform to 1536 well: CatchPoint for cyclic nucleotides and tyrosine kinase activity
- Advances in High Throughput Kinase Assays via Fluorescence Polarization
- Analysis of GPCR Signaling Events Using HCS Technology
- Analysis Of The Biophysical Properties Of Sodium Channel NaV1.5 Using An Automated Electrophysiology System
- Applications of IonWorks HT in ion channel drug discovery and compound profiling
- AquaMax DW4: A Flexible Tool for Heterogeneous 1536 Assays
- Aqueous Solubility Measurement - Kinetic vs. Thermodynamic Methods
- Aqueous Solubility Measurement: Kinetic vs. Thermodynamic Methods
- Assay Comparison: Comparison of Compound Characterization with Transfluor® and AlphaScreen™
NORAK poster SBS 2003)
- Automated Z-TagSM Zebrafish Assay for Anti-Angiogenic Compound Screening (SBS 2007 Poster)
- Automation of online decision making and offline analysis in the PatchXpress 7000A electrophysiology system
- Bringing Primary Cell Relevance to Screening: Clonetics Conditionally Immortalized Cells and QBT Fatty Acid Uptake Assay for High Throughput Screening
- Calcium Flux Assay Development on FLIPR Tetra: Setting the New Standard in Fluorometric Imaging Plate Readers
- Cell Cycle Application Module: Automated Cell Cycle and Apoptosis Profiling Using High Content Screening (ACT 2006 Poster)
- Cellular Informatics Analysis of High Content Screening Data
- Characterization of Ion Channels in Cor.At® mES-derived Cardiomyocytes on the PatchXpress® 7000A System
- CHARACTERIZATION OF KINASE SUBSTRATE SPECIFICITY USING IMAP: Application for the CDK Family
- Combining FLIPR and Transfluor®: A Novel Assay for the Sequential Analysis of Calcium Flux and Receptor Desensitization
- Combining FLIPR and Transfluor®: A Novel Homogeneous Assay for Sequential Compound Analysis with FLIPRTETRA™ and Transfluor®
- Combining FLIPR and Transfluor®: Characterization of GPCR Modulators Using a Homogenous FLIPR/Transfluor® Assay
(MDC Poster SBS 2006)
- Comparison of Calcium Flux Assays Across Multiple GPCRs: Implications for Compound Profiling and Screening
- Comparison of Photina® Luminescent Calcium Mobilization Assays on both the FlexStation® 3 and FLIPRTETRA® Systems
- Comparison of the IMAP Fluorescence Polarisation Assay with the Scintillation Proximity Assay for Phosphodiesterase Activity.
- Continuous ion current recordings during drug delivery and washout
- DDT 2005 Presentation: Cellular Informatics Analysis of High Content Screening Data
- Development of an HTRF® Antibody Screening Assay for Selection of Production Cell Lines
- Discovery of a gene expression signature that predicts clinical outcome in breast cancer patients treated with tamoxifen
- Dual Luciferase® Reporter Assay Detection on Next-Generation
FlexStation® 3 Microplate Reader with Integrated Fluidics
- Dual-Glo Luciferase Assay on LMax II384 and Analyst GT Microplate Readers
- Endothelial Cell Migration through Collagen is Independent of Collagenolysis
- Evaluation of 1536-Well Calcium Mobilization Assays Over Time Using the New Aequorin Option for the FLIPR Tetra® System
- Evaluation of AequoZen™ FroZen Cells Starter Kit Using the Aequorin Option for the FLIPR Tetra® System
- Expansion of IMAP to Assays Requiring High-ATP and Use of Substrates With A High Proportion of Acidic Residues.
- FLIPR Bibliography
- FLIPR Calcium 3 Kit: 384- and 1536-well Assay Development on FLIPR Tetra
- FLIPR Calcium Kit: 384- and 1536-well Assay Development on FLIPR Tetra
- FLIPR Tetra and Aequorin-Based Luminescence Assays: IB-MECA Stimulated Calcium Mobilization in CHO-K1 Cells Expressing Adenosine A3 Receptor
- FLIPR Tetra Membrane Potential Kit Assay Development in 384-well and 1536-well Format
- FLIPR® Calcium 4 Assay Kit - Next Generation No-Wash Calcium Kit: Performance Evaluation and Competitive Comparsion Using FLIPR Tetra®
- Fluorescence Polarization Assays of Kinases and Phosphatases with Red-Labeled Peptide Substrates
- Fluorescence Polarization Assays of Proteases with the IMAP Platform
- Fluorescence-based Neurotransmitter Transporter Uptake Assay in Primary Neuronal Cultures
- FP and TR-FRET kinase assays with automated liquid handling
- Gene Expression Profiles of Human Breast Cancer Progression
- Gene Expression Profiling of Formalin-fixed, Paraffin-embedded Archival Tissue Following Laser Capture Microdissection
- Gene Expression Profiling of Microdissected Human Breast Cancer Cells from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays
- Gene Expression Profiling of Microdissected Samples Using GeneChip® Arrays
- Gene Expression Signatures Associated with Clinical Outcome via Laser Capture Microdissection
- High Density Kinase Screening and Selectivity Determination Using the IMAP Platform
- High Sensitivity Linear Amplification for Small Amounts of RNA
- High-quality RNA Retrieval from Immunofluorescently-stained LCM Samples
- Homogeneous Fluorescence Analysis of Cellular Fatty Acid Transport
- HTS Technologies for Potassium Channel Screening
- IMAP Assays of Protein Kinases: Determination of Kinetic and Inhibition Constants at High Substrate Conversion.
- IMAP TR-FRET: Use of the First Generic TR-FRET based Kinase Assay Platform with Protein Substrates and Biotin-Substrate/Streptavidin Systems
- IMAP™ Kinase and Phosphatase Assays in Automated High-Throughput Applications
- Kinase Profiler with IMAP
- Kinase Profiling Studies at Roche: The Establishment of a Twenty Kinase Profiler and Its Application
- LOPAC™ screen for PDE1 using the IMAP® platform with TR-FRET detection
- Luminescent GPCR and luciferase reporter assays on SpectraMax® L
- Measurement of Phenolic Compounds in Red Wines Using Molecular Devices SpectraMax® Plus 384 Plate Reader
- Measurement of Proteosome Inhibition in Live Cells on the Analyst GT, FlexStation and Gemini EM Microplate Readers Using the BD Biosciences Proteasome Sensor
- Measurement of Proteosome Inhibition in Live Cells on the Analyst®GT, FLEXstation® and Gemini EM Microplate Readers Using the BD Biosciences ProteasomeSensor
- Measurement of Residual Sugar and Malate in Wines Using Molecular Devices SpectraMax® Plus 384 Plate Reader
- Molecular classification of carcinomas of unknown primary by gene expression profiling from formalin-fixed paraffin-embedded tissues
- Multiplex Assays in IMAP Using the Progressive Binding System
- Multiplexing and Cascade Assays with the IMAP FP Platform
- Multiplexing fluorescent and chemiluminescent live cell reporters to dissect NFκB signal transduction requirements
- Multiplexing: The Challenge of Analyizing HCA
- Non-Antibody Based Fluorescent Polarization Assay for Monitoring Kinase Activities Optimized on Analyst, a Multimode Fluorescent Detection System
- Optimization of Measurement Parameters and Performance Comparison for
Analyst GT and Analyst HT or Acquest
- Optimizing the hERG Assay on the PatchXpress 7000A System for Compounds that Demonstrate Non-specific Binding
- Orphan Receptors Transfluor® Screening: Quantification of the Spatial Redistribution of Fluorescence for the High Throughput Screening of Orphan GPCRs
- Orphan Receptors Transfluor® Screening: Screening Orphan GPCRs in Stable Cell Lines with Transfluor® Technology
(NORAK Poster)
- Patching transiently transfected ion channels on an automated electrophysiology system
- Performance of a Miniaturized Calcium Mobilization Assay on 384 Well Low Volume Microplates
- Phosphorescent O2 -Sensitive Probes for Plate Reader-Based Analysis of Biological Oxygen Consumption
- Practical Tips for Axon pCLAMP Software and Amplifiers
- Quantification of fatty acid uptake in HepG2 cells and adipocytes using the QBT Fatty Acid Uptake Assay
- Quintiles Rapid ICE
- Rapid Solution Exchange and Ligand-Gated Channel Studies on the PatchXpress 7000A Automated Patch Clamp System
- Ratiometric FRET-based Ion Channel Modulation Assay Development on FLIPR Tetra
- Recent Developments in High Throughput, Turn-Key Permeability Compound Ranking Assays
- SBS 2003 Presentation: Automated Neurite Outgrowth Application Module
- SBS 2004 Presentation: Quantitation of Apoptosis, Necrosis and Cell Death Using High Content Screening
- SBS 2005 Presentation: Image-Based High-Content Screening of Fatty Acid Uptake
- SBS 2005 Presentation: Multiplicity: The Challenge of Analyzing High-Content Screening Data
- SBS 2005 Presentation: Simultaneous Image Analysis of Multiple Apoptotic Pathways
- Setting up a Kinase Profiler with IMAP
- SFN 2006: Validation of Automated Neurite Outgrowth Image Analysis
- Testing the Performance of SealChip in hERG Assay
- The IMAP Substrate Finder for Tyrosine Kinases: Applications for HTS Assay Development
- The IMAP Substrate Finder: Applications for HTS assay development
- The Use of the Substrate Finder for Ser/Thr Kinases in Development of IMAP Assays for the PKC Family
- Time-resolved Fluorescence Resonance Energy Transfer detection for Lipid kinases using the IMAP(R) platform: Non-radioactive and antibody independent assay for Sphingosine Kinase
- TR-FRET Detection for the IMAP Platform
- Transfluor® Screening: Xsira Presentation: Transfluor® Technology: Discovering the next generation of GPCR-based drugs
(XSIRA Presentation Marcus Evans 2004)
- Transfluor® Assay Development (Wyeth, 2006)
- Transfluor® Screening and Assay Comparison: Merging High-Content Screening (HCS) with High-Throughput Screening (HTS) Systems
(Roche Presentation HCA 2004)
- Transfluor® Screening and Assay Comparison: Xsira Presentation: High Throughput Screening with Transfluor® Technology
(XSIRA Presentation DDT 2003)
- Transfluor® Screening: Development, Conduct and Results of Two High Throughput Screens Using Transfluor® Technology
NORAK Poster SBS 2003)
- Transfluor® Screening: Merck Presentation: Integrating High-Content Assays with Early Lead Identification Strategies
(Merck Presentation HCA 2004)
- Transfluor® Screening: Microtiter Plate Evaluation for Use with Cell-Based, High Content Imaging Systems
(NORAK Poster SBS 2003)
- Transfluor® Screening: Microtiter Plate Evaluation Screening: GPCR HTS using Transfluor® and the InCell Analyser
(AstraZeneca Presentation SBS 2003)
- Transfluor® Screening: Multiplexing of Transfluor® Technology to Detect Responses to Gs-,Gi- and Gq-coupled Receptors in the Same Well
(NORAK Poster SBS 2003)
- Transfluor® Technology: A Universal High-Content Screening Assay for G Protein-Coupled Receptors
- Transfluor®: Merck Presentation: Transfluor® Technology: Views from the End-User
(Merck Presentation HCA 2004)
- Use of IMAP TR-FRET detection mode for IMAP Substrate Finders
- Use of IMAP TR-FRET detection mode for the IMAP AGC and CAMK Substrate Finder
- Use of Multi-Parametric Analysis and Image Drill Down to Facilitate the Study of Cell Cycle and Apoptosis Modulators (SBS 2007 Poster)
- Using IMAP Technology to Identify ATP Non-Competitive Kinase Inhibitors in 1536-well Format
- Validation of Different Aequorin Mutants for GPCR Screening Using the FLIPR Tetra® System with Aequorin Option - Millipore
- Xsira Presentation: High Throughput Screening with Transflour® Technology (28 pages)
- Xsira Presentation: Transfluor® Technology: Discovering the next generation of GPCR-based drugs (36 pages)
Manuals
Program Updates
2004 Posters & Presentations
2003 Posters & Presentations
Software Updates
Application Bulletins and Posters
Version History
Automation Information
Declaration of Conformity
Application Reference Guides
Tech Tips and Analysis Macros
IonWorks HT Technical Support Documents
Installation Notes
IonWorks Quattro Technical Support Documents
Materials Safety Data Sheets
Product Update Archive
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