Cellular Imaging Comparison Chart
Molecular Devices high content imaging systems bring powerful cellular and sub-cellular analysis tools to the screening environment. Featuring industry-leading image analysis software and powerful database tools, the systems provide researchers with insights into how potential therapeutics affect multiple cellular processes.
Molecular Devices offers three platforms for high content imaging: ImageXpressMICRO™, ImageXpressULTRA™ and IsoCyte™.
The ImageXpressMICRO™ features a small footprint and utilizes an optional high-speed laser auto-focus option that allows for the acquisition of more than 50,000 wells/200 plates per day. The system is easily upgradeable to support full environmental control (CO2, humidity and temperature) as well as advanced liquid handling for simultaneous liquid addition and reading.
The ImageXpressULTRA™ is a true point-scanning confocal system that features laser-based illumination for sequential or simultaneous imaging.
The IsoCyte™ is an automation-friendly benchtop laser scanning imager available in either a single or dual laser configuration. The IsoCyte™ enables robust real-time assays for microarray, bead, cell and colony classification and enumeration in user-defined or commercially available formats.
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ImageXpressULTRA |
ImageXpressMICRO |
IcoCyte™ |
| Imaging Modality |
Scanning Confocal with adjustable depth of focus via pin hole |
Widefield Microscope |
Laser scanning imager with 400 μm confined detection region |
| Environmental control option |
|
 |
|
| Liquid handling option |
|
1 |
|
| Fixed cell imaging |
|
|
|
| Label Free Imaging |
|
Brightfield / phase contrast 2 |
Laser Scatter |
| Anisotropy |
|
|
|
| Light source |
2 to 4 excitation lasers |
300W xenon arc lamp |
1 or 2 excitation lasers |
| Detection |
PMTs |
CoolSNAPES (standard) CoolSNAPHQ (option) |
PMTs |
| Image-based auto-focus |
|
|
Not Applicable
200 μm depth of focus |
| High-speed laser auto-focus |
|
Option |
| Robotics/automation option |
|
|
|
| Automated filter cube changer |
|
|
|
| Automated objective changer |
|
|
Not Applicable |
| Air objectives |
4X - 100X |
1X - 100X |
Not Applicable |
| Oil-immersion objectives |
40X-100X |
40X-100X |
Not Applicable |
| Automated X-Y sample stage |
|
|
|
| Microtiter plates |
6-, 12-, 24-, 48-, 96-, 384-, 1536-well
plastic or glass plates3 |
| Microscope slides |
|
|
|
| Computer workstation |
|
|
|
| MetaXpress image acquisition software |
|
|
|
| MetaXpress image analysis software with MetaMorph backbone |
|
|
Option |
| MDCStore integrated database |
|
|
Option |
| AcuityXpress cellular informatics software |
Option |
Option |
Option |
| MetaXpressPowerCore™ |
|
|
|
| On the fly analysis |
|
|
|
1 Not compatible with transmitted light
2 Not compatible with liquid handling
3 Certain plate heights are not compatible with the Environmental Control Option
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