2002 MDC 6th International Drug Discovery Conf.

This year's International Drug Discovery Conference was a huge success, thanks to all of our presenters! The presentation topics are listed below. For those presentations having a downloadable (pdf) version, we have indicated the file size of the pdf.

screening protein kinases using IMAP®

• Tyrosine Kinases as Drug Targets; their History, Diseases and Difficulties (with Special Reference to Gleevac). Future Discovery Trends in Research and the Next Generation of Kinase Drug Targets
  Tom Roberts, Ph.D., Chair, Harvard Medical School
• Screening for Inhibitors of MAPKAP2, a Serine-Threonine Kinase, Using IMAP
  James P. O'Connell, Ph.D., Celltech

  Download presentation  [PDF]  (870 K)
  

• Application of IMAP Technology to p38a Protein Kinase
  Bonnie L. Bertolaet, Ph.D., Triad Therapeutics

  Download abstract  [PDF] 
  Download presentation  [PDF]  (520 K)

• Screening for Tyrosine and Serine-Threonin Kinase Inhibitors: Validation and Application of IMAP Technology and Specificity Testing of HTS Hits
  Jason Peter Brown, Ph.D., Upstate

  Download abstract  [PDF] 
  Download presentation  [PDF]  (690 K)

target validation using homogenous assays

• Experiences with Fluorescence Methods in Ultra High-throughput Screening and Drug Discovery Using the Analyst™
  Michael K. Helms,Ph.D., Exelixis, Inc.

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• Characterizing the Kinetics of Receptor-Antagonist Interactions Using a Fluorescence Polarization Competition Method on a Plate Reader
  Susan M. Keating, Ph.D., Genentech, Inc.

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• Characterization of the 5-HT6 Receptor using CatchPoint™ cAMP Assay: Comparison with FP and FlashPlate™
  Martyn D, Wood, Ph.D., GlaxoSmithKline

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  Download presentation  [PDF]  (2.0 MB)
  

ion channels by electrophysiology

• Ion Channels in Drug Safety and Drug Discovery
  Arthur M. Brown, M.D., Ph.D., ChanTest, Inc.
  

  Download abstract  [PDF] 
  Download presentation  [PDF]  (2.8 MB)
  

• IonWorks™ APC: Automated Patch Clamp Electrophysiology on Silicon-Based Planar Substrates
  Christian Schmidt, Ph.D., Cytion, S.A.

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• IonWorks™ HT: High-throughput Patch Clamp Electrophysiology
  Wilhelm G. Lachnit, Ph.D., Molecular Devices

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ion channels on FLIPR® and FlexStation™

• Application of FLIPR® to the Evaluation of Mechanisms of Action of Novel Neurotoxins: Ion Channels as Molecular Targets
  Thomas F. Murray, Ph.D., University of Georgia, College of Veterinary Medicine

  Download abstract  [PDF] 
  Download presentation  [PDF]  (1.1 MB)
  

• Characterization of Recombinant and Native Voltage-Gated Sodium Channels (VGSCs) Using Membrane Potential- or Calcium-Sensitive Dyes
  Jerri H. Martin, Theravance, Inc.

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• Using the FlexStation™ to Investigate Voltage-Gated Calcium and Sodium Channels
  Stuart D. C. Ward, Ph.D., Ionix Pharmaceuticals, Ltd.

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  Download presentation  [PDF]  (290 K)
  

• Application of Molecular Devices' Fluorescence Membrane Potential Sensitive Dye for the Study of a Human Electrogenic Transporter
  Giorgia Michela Stucchi, Ph.D., Axxam

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  Download presentation  [PDF]  (1 MB)
  

• Progress Toward a High-throughput Assay for a hERG Channel Blocker
  Byron Taylor, Amgen

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  Download presentation  [PDF]  (660 K)
  

screening on FLIPR®

• Improved FLIPR® HTS for a Chemokine GPCR Using the Molecular Devices Calcium Plus Reagent Kit
  Ralph J. Garippa, Ph.D., Hoffman-La Roche

  Download abstract  [PDF] 
  Download presentation  [PDF]  (550 K)
  

• Development and Validation of a High-throughput Cell-based Screen for a Chemokine Receptor Using FLIPR® and the Calcium Plus Kit
  Sofia Ribeiro, Ph.D., Berlex Laboratories, Inc.

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• 1536-well FLIPR®: A Possibility or Probability?
  Gary Allenby, Ph.D., AstraZeneca

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  Download presentation  [PDF]  (1 MB)
  

• FLIPR®-based Assay for Screening Inhibitors of the Multidrug Resistance Gene MDR1 in vitro
  Vee Mitchell, GlaxoSmithKline

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  Download presentation  [PDF]  (900 K)
  

• AptuScreen: A Novel Real-Time cAMP Assay for FLIPR®
  Yong Yao, Aptus Genomics