Scientific Posters

Please select from among the application categories below.

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Electrophysiology

• Characterization of Ion Channels in Stem Cell-derived Cardiomyocytes on an Automated Parallel Patch Clamp System
• Rapid Solution Exchange and Ligand-gated Channel Studies on the PatchXpress 7000A Automated Patch Clamp System
• Analysis of the Biophysical Properties of Sodium Channel Naν1.5 Using an Automated Electrophysiology System
• Automation of Online Decision Making and Offline Analysis in the PatchXpress 7000A Electrophysiology System
• Patching Transiently Transfected Ion Channels on an Automated Electrophysiology System
• Improved Assay of Transiently Transfected Ion Channels on an Automated Electrophysiology System
• Continuous Ion Current Recordings During Drug Discovery Delivery and Washout on an Automated Electrophysiological Platform
• Characterization of Ion Channels in Stem Cell-derived Cardiomyocytes on an Automated Parallel Patch Clamp
• Optimizing the hERG Assay on the PatchXpress 7000A System for Compounds that Demonstrate Non-specific Binding 

Cellular Screening

• Live cell Gq-, Gi- and Gs- coupled GPCR second messenger signaling on the FLIPR Tetra system
  with the Promega GloSensor cAMP assay
  
• Automated Functional Cellular Analyses of Human iPS-derived Cardiomyocytes
  
• Performance of the 1536-Well Pipettor Head on the FLIPR Tetra Instrument - Lab Automation 2009
• Calcium Flux Assay Development on the FLIPR Tetra Instrument: Setting the New Standard in Fluorometirc Imaging Plate Readers
• Combining the FLIPR Tetra Instrument and the Transfluor Assay: A Novel Assay for the Sequential Analysis of Calcium Flux and Receptor Desensitization
• Combining the FLIPR Tetra Instrument and the Transfluor Assay: A Novel Homogenous Assay for Sequential Compound Analysis II
• Evaluation of 1536-well Calcium Mobilization Assays Over Time Using the New Aequorin Option for the FLIPR Tetra System
• Evaluation of AequoZen FroZen Cells Starter Kit Using the Aequorin Option for the FLIPR Tetra System
• Functional Characterization of Recombinant Muscarinic M3 Receptors in Assay Ready Frozen Cells Using a Novel Calcium Assay Kit on the FLIPR Tetra Instrument
• FLIPR Tetra Membrane Potential Kit Assay Development in 384-well and 1536-well Format
• FLIPR Calcium Kit: 384- and 1536-well Assay Development on FLIPR Tetra
• FLIPR Calcium 4 Assay Kit - a New Generation Quench Based, No-wash Calcium Kit: Performance Evaluation and Competitive Comparison Using FLIPR Tetra
• Optimization of Calcium Flux Assays with Chemiscreen™ Calcium-optimized Cell Lines and FLIPR Calcium 5 Assay Kit
• Evaluation of Pipetting and Detection Performance in 1536-well Format for the FLIPR Tetra System
• Cell Based Assays on the FLIPR Tetra System: Comparison of the FLIPR Calcium 5 Assay Kit to Other Fluorescence Based Calcium Flux Assays
• FLIPR Tetra and Aequorin Based Luminescence Assays: IB-MECA Stimulation Calcium Mobilization in CHO-K2 Cells Expressing Adenosine A3 Receptor
• Calcium Mobilization in CHO M1WT3 Cells by Carbachol Stimulation of the Muscarinic Receptor Using FLIPR Calcium 3 Kit and FLIPR Tetra
• Ratiometric FRET-based Ion Channel Modulation Assay Development on FLIPR Tetra with Voltage Sensor Probes
• Evaluation of Calcium Mobilization Assays Over Time Using the New Aequorin Option for the FLIPR Tetra System
• New Driver Design Increases Throughput of FLIPR Tetra System Integrated on BioCel
• Optimizing a Luminescent Calcium Biosensor for Screening GPCRs on Multiple Detection Platforms
• Evaluation of Cryopreserved Bacmam Transduced Aequorin Cells in 384- and 1536-well Suspension Cell Assays Using the Aequorin Option for the FLIPR Tetra System
• Optimizing a Transient Receptor Potential (TRP) Channel Assay on the FLIPR Tetra Instrument Using hTRPV1-HEK293 Cells and the FLIPR Calcium 5 Assay Kit

• Predictive Assays for High Throughput Assessment of Cardiac Toxicity and Drug Safety

Imaging   See disclaimer   

• Predictive High-Content/High-Throughput Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell (iPSC)-Derived Hepatocytes
• Customizing Your high Content Analysis for Accelerated Toxicity Screening
• Multiplexed High Content Hepatotoxicity Assays using Induced Pluripotent Stem Cell Derived Hepatocytes
• Multiplexed Hepatotoxicity Assays using iCell Hepatocytes
• Novel Functional Phenotypes in Induced Pluripotent Stem Cell-Derived Neurons from Patients with LRRK2 G2019S Mutation
• Multiplexed High Content Assays for Predictive Hepatotoxicity using iPSC-Derived Hepatocytes

• Predictive Assays for High Throughput Assessment of Cardiac Toxicity and Drug Safety

• Accelerating Your High Content Imaging: A Case Study Using Neuronal Toxicity Screening
• High Content Neuronal Toxicity Assays Using iPSC Derived Neurons
• Development and Characterization of Human iPSC-derived Neurons for Drug Discovery Applications
• High Content Analysis of Neural Stem Cell Expansion and Differentiation 
• Automated Functional Cellular Analysis of Human iPS-derived Cardiomyocytes for Cardiovascular Research, Toxicity, and Drug Discovery         
• High Content Analysis of a Robust 384-Well Cell Migration Assay
• Novel High Content Stem Cell-based Assays for Screening 
• Human iPS-derived Cardiomyocytes for Cardiotoxicity Screening
• Automated Functional Cellular Analysis of Human iPS-derived Cardiomyocytes
• High Content Analysis of an Automatable 3-Dimensional Cell Invasion Assay
• Homogeneous Multiplexed Assay for Hematopoietic Stem Cell Toxicity
  
• Homogenous Binding Assay: Comparing Imaging Systems and Optimizing Acquisition Parameters for High-Throughput Screening
• High Content Analysis of Neuronal Stem Cell Differentiation and Expansion
• Use of Multi-Parametric Analysis and Image Drill Down to Facilitate the Study of Cell Cycle and Apoptosis Modulators  
• Discovery-1™: Automated Neurite Outgrowth Application Module
• A Novel High-Throughput Assay for Screening Factors with Effects on Neurite Outgrowth
• Analysis of GPCR Signaling Events Using HCS Technology
• Quantitation of Apoptosis, Necrosis and Cell Death Using High Content Screening
• Cellular Informatics Analysis of High Content Screening Data
• Multiplicity: The Challenge of Analyzing High-Content Screening Data
• Combining FLIPR and Transfluor: A Novel Assay for the Sequential Analysis of Calcium Flux and Receptor Desensitization
• Image-based High-content Screening of Fatty Acid Uptake
• Simultaneous Image Analysis of Multiple Apoptotic Pathways
• Examining the Cell Cycle and Apoptosis Using MetaXpress
• Live Cell Imaging in Target Validation and Lead Optimization
• Developing a Robust Automated Image-based Assay
• Combining Calcium Flux and Receptor Desensitization: A Novel Homogenous Assay for Sequential Compound Analysis with FLIPR® Tetra and Transfluor
• Validation of Automated Neurite Outgrowth Image Analysis
• Fluorescence Screening Platform for Embryonic Stem Cells and Embryoid Bodies
• A Hepatocyte Culture Model for Identifying Liver Toxic Drugs
• Characterization of GPCR Modulators Using a Homogenous FLIPR/Transfluor Assay
• Development of a 3-color Assay for Mitosis and Apoptosis Using the Laser-scanning IsoCyte and Comparison with the Microscope-based INCell Analyzer 1000
• High Throughput Fluorescence Polarization Screening Assays Using the IsoCyte Laser Scanning Platform
• Use of IsoCyte HTS as High Throughput Platform for Cytotoxicity, Mitotic Index, and Cell Cycle Analysis
• Acoustic Droplet Ejection and Laser Scanning Platforms Enable High-Throughput Cell Dispensing and Quantitation
• High Throughput Anchorage-Independent Cell Colony Growth Assay with the IsoCyte HTS Platform
• Automated Z-TagSM ZebraFish Assay for Anti-Angiogenic Compound Screening
• Flow Cytometry Analysis of Mitotic Index Data from IsoCyte DL Laser Scanning Cytometer
• High Throughput Cell Migration Assay with the IsoCyte Laser Scanning Platform
• Applying Flow Cytometry Analysis Techniques to Measure Mitotic Index Using the IsoCyte DL Laser Scanning Cytometer
• Managing and Evaluating an HCS siRNA Screen of the p53 Pathway with AcuityXpress Software
• Novel Imaging and Analysis of Zebrafish for High Throughput Screening
• Direct Fluorescent Labelling Approaches for G-protein Coupled Receptors Using the ImageXpress Ultra
• Development of a High-throughput Assay for ALS Target Discovery Using Human Stem Cell-derived Motor Neurons
• High Throughput Imaging Assay to Assess Cell Migration on Multiple Substrates
• High-Throughput Multiplexed Assay for Analysis of Hematopoietic Stem Cells Differentiation and Hematopoietic Toxicity
• High-Throughput Multiplexed Inflammation Assay Using Primary Cells
• High Throughput Imaging Assay to Assess Cell Migration

Label-Free Analyses

• Introducing the CellKey384 System, a Label-free High Throughput Cell based Assay for Functional Screening of Cellular Receptors
• The CellKey Small Sample 96W Microplate Enables Cost-Effective Analysis of Endogenous Receptors in Primary Cells and Non-Adherent Cells
• A Label-free Cell-based Assay Technology for Functional Evaluation of Endogenous Receptors
• Identification of the G-protein Coupling Mechanism of GPCRs Using a Label-free Live-Cell Assay
• Investigating the FcERI Receptor Signaling Pathway and Mast Cell Degranulation Using a Novel Label-Free Cell-Based Assay Technology
• A Label-free Cell-based Assay Technology for Functional Comparison of Endogenous and Transfected Receptors
• Cataloging Endogenous Cell Surface Receptors and Analyzing Their Functional Activity using Label-Free Cellular Dielectric Spectroscopy
• Complex Signaling Pathway Analysis and Pharmacological Profiling of a Transfected GPCR using Cellular Dielectric Spectroscopy, A Novel Cellular Assay Platform
• Cellular Dielectric Spectroscopy: A Label-Free Technology for the Functional Evaluation of Receptor-Mediated Signaling
• Cell-based Assay Optimization Using a Non-invasive, Label-free Cell Culture Monitoring System
• Analysis of Endogenous Chemokine Receptor Activity in Mammalian Immune Cells Using Cellular Dielectric Spectroscopy
• Pharmacological Analysis of Endogenous ß-adrenergic Receptors in Adherent & Non-Adherent Cells Using Cellular Dielectric Spectroscopy
• Hit To Lead Analysis for GPCR Targets using CDS - A Label-Free Functional Cell-Based Technology
• Development of a Label-Free Cellular Assay for an Endogenously Expressed GPCR Using Cellular Dielectric Spectroscopy
• Cellular Dielectric Spectroscopy - A Label-free Technology for Drug Discovery
• Performing Pharmacological Studies of Mammalian Receptors in Live-cell Label-free Assays in Cell Culture Media
• End-point Assays on the CellKey™ System
• Capturing Higher-value GPCR Screening Data with a Combined Approach: The FLIPR Tetra System and the CellKey 384 System
• Application of a Label-free Cell-based Assay Platform for High Throughput Functional Screening of Cellular Receptors
• Cellular Dielectric Spectroscopy: A Novel, Label-free Cell-based Assay for Drug Discovery
• Label-free Functional Analysis of Endogenous Receptors in Primary Cell Types
• Pathway Analysis of Receptor-mediated Signaling Using Cellular Dielectric Spectroscopy: A Label-free Cell-based Technology
• Pharmacological Analysis of Endogenous Adenosine Receptors in Neuronal Cells Using a Label-free Live-cell Assay
• Evaluation of Cryo-preserved Cells for the Measurement of Functional G-protein Coupled Receptor Activity Using the CellKey System
• A Novel Bioimpedance-based Assay for GABAA Receptor Activity
• Demonstrating the Benefits of Label-free Cell-based Assays Applied to Primary Screening
• Monitoring Functional Inhibition of a Cell Surface Receptor via RNA Interference with the CellKey System
• Monitoring Effects of Cytotoxic and Apoptotic Compounds on HeLa Cells Using CDS: A Novel, Label-free Cell-based Technology
• Tracking Receptor-mediated Signaling Using CDS - A Novel, Label-free Cell-based Technology
• A Label-free Technology for the Functional Evaluation of Non-adherent Cells
• Cellular Dielectric Spectroscopy: A Label-free Technology for Drug Discovery Applications
• Analyzing Functional Activity of Endogenous Cell Surface Receptors Using CDS: A Novel, Label-free Cell-based Technology
• A CDS System for Label-free Cellular Assays in 96-well Format
• Analysis of Endogenous Growth Factor Receptor Activity in Mammalian Cancer Cell Lines Using a Label Free Live Cell-based Assay
• Analysis of GPCR and PTKR Receptor-mediated Signaling Using Cellular Dielectric Spectroscopy: A Label-free Cell-based Technology
• Elucidation of a complex GPCR Signaling Using Impedance-based Technology
• Development of Functional Assays That Discriminate Neutral Antagonists and Inverse Agonists
• Comparison of a Label-free Technology with Conventional Fluorescent-based Technologies for pharmacological Profiling of GPCRs
• Pharmacological Profile Correlations Between Recombinant and Non-recombinant GPCRs Using a Label-free Technology

Microarray-Based Analyses

• No posters available at this time.

Microplate-Based Analyses

• FlexStation® 3 System : Unwinding a GPCR pathway through Calcium flux and cAMP/IP3 production on a single instrument
  
• SpectraMax Microplate Readers: A complete solution for Transcreener® assays 
• Quantification of cytokines on the SpectraMax® Paradigm® Multi-Mode Microplate Detection Platform using Alpha Technology
• Homogenous High Throughput Live Cell GPCR Functional and Surface Binding Assays

• A Stable, Sensitive Fluorescence-based Method for Detecting cAMP
• Comparison of the IMAP Fluorescence-based Polarisation Assay with the Scintillation Proximity Assay for Phosphodiesterase Activity
• Aqueous Solubility Measurement - Kinetic vs. Thermodynamic Methods
• Development of an HTRF Antibody Screening Assay for Selection of Production Cell Lines
• Dual Luciferase Reporter Assay Detection on Next-Generation FlexStation 3 Microplate Reader with Integrated Fluidics
• FP and TR-FRET kinase assays with automated liquid handling
• Luminescent GPCR and luciferase reporter assays on SpectraMax L
• Measurement of Phenolic Compounds in Red Wines Using Molecular Devices SpectraMax® Plus 384 Plate Reader
• Measurement of Proteosome Inhibition in Live Cells on the Analyst GT, FlexStation and Gemini EM Microplate Readers Using the BD Biosciences Proteasome Sensor
• Measurement of Residual Sugar and Malate in Wines Using SpectraMax Plus 384 Plate Reader
• Multiplexing Fluorescent and Chemiluminescent Live Cell Reporters to Dissect NFκB Signal Transduction Requirements
• Phosphorescent O2 -Sensitive Probes for Plate Reader-Based Analysis of Biological Oxygen Consumption
• Quantification of Fatty Acid Uptake in HepG2 Cells and Adipocytes Using the QBT Fatty Acid Uptake Assay
• Recent Developments in High Throughput, Turn-Key Permeability Compound Ranking Assays
• IMAP Assays of Protein Kinases: Determination of Kinetic and Inhibition Constants at High Substrate Conversion
• Expansion of IMAP to Assays Requiring High-ATP and Use of Substrates with a High Proportion of Acidic Residues
• Fluorescence Polarization Assays of Proteases with the IMAP Platform
• Fluorescence Polarization Assays of Kinases and Phosphatases with Red-labeled Peptide Substrates
• High-Density Kinase Screening and Selectivity Determination Using the IMAP Platform
• A Comparison of FRET and FP Assay Platforms for a ser/hr Kinase
• IMAP Kinase and Phosphatase Assays in Automated High-Throughput Applications
• Kinase Profiler with IMAP
• Setting up a Kinase Profiler with IMAP
• The IMAP Substrate Finder: Applications for HTS Assay Development
• Use of IMAP TR-FRET Detection Mode for the IMAP AGC and CAMK Substrate Finder
• LOPAC Screen for PDE1 Using the IMAP Platform with TR-FRET Detection
• Time-resolved Fluorescence Resonance Energy Transfer Detection for the IMAP Platform: Generic, Homogenous, TR-FRET Based HTS Assays for Kinases
• Time-resolved Fluorescence Resonance Energy Transfer Detection for Lipid Kinases Using the IMAP Platform: Non-radioactive and Antibody Independent Assay for Sphingosine
• IMAP TR-FRET: Use of the First Generic TR-FRET Based Kinase Assay Platform with Protein Substrates and Biotin-substrate/Streptavidin Systems
• The IMAP Substrate Finder for Tyrosine Kinases: Applications for HTS Assay Development
• Kinase Profiling Studies at Roche: The Establishment of a Twenty Kinase Profiler and its Application
• Multiplex Assays in IMAP Using the Progressive Binding System
• Multiplexing and Cascade Assays with the IMAP Fluorescence Polarization Platform
• Non-antibody Based Fluorescent Polarization Assay for Monitoring Kinase Activities Optimized on Analyst, a Multi-mode Fluorescent Detection System
• Using IMAP Technology to Identify ATP Non-Competitive Kinase Inhibitors in 1536-well Format
• Characterization of Kinase Substrate Specificity Using IMAP Application for the CDK Family
• Use of IMAP TR-FRET Detection Mode for the IMAP Substrate Finder
• The Use of the Substrate Finder for Ser/Thr Kinases in Development of IMAP Assays for the PKC Family
• Advances in High Throughput Kinase Assays via Fluorescence Polarization
• Maximizing Cell Wash Performance with the AquaMax 2000/4000 Microplate Washers
• Two Secreted Orthogonal bioluminescent Reporters for Non-destructive Ultrasensitive Assays
• Fluorescence-based Neurotransmitter Transporter Uptake Assay in Primary Neuronal Cultures
• A Fluorescence-based Neurotransmitter Transporter Uptake Assay
• Bringing Primary Cell Revelance to Screening: Clonetics Conditionally Immortalized Cells and QBT Fatty Acid Uptake Assay for High Throughput Screening
• Homogenous Fluorescence Analysis of Cellular Fatty Acid Transport
• Image-based High-content Screening of Fatty Acid Uptake

Disclaimer: The documents available through this page are maintained as an archive.  These documents appear substantially as originally presented or published.  Accordingly, these digital documents may contain the former company name and/or product names.