Axon Digidata 1440A Data Acquisition System
Designed for fast results, the Digidata 1440A Digitizer is a data acquisition system for electrophysiology recordings.
The Axon Digidata® 1440A Digitizer is a low-noise high-resolution 16-bit data acquisition system for electrophysiology recordings. It is self-contained and communicates with the host computer via a USB 2.0 interface for extremely easy installation and setup. Designed for fast results, the Digidata 1440A Digitizer comes with AxoScope software for Microsoft Windows OS and is ready to acquire data immediately after installation. Absolutely no programming is necessary.
The Digidata 1440A Digitizer features a maximum sampling rate of 250 kHz per channel, with an outstanding total data throughput rate of 4 mega-samples per second. This enables you to capture even the fastest signals in the biorelevant frequency range. Both the inherent digitizer noise and channel crosstalk noise are rated at less than ±1 mV average p-p at 10 kHz, within a ±10 V input range, making the Digidata 1440A System one of the quietest digitizers on the market.
For intuitive setup, the front panel is clearly laid out with sixteen analog input channels and four analog output channels, eight general digital outputs, one dedicated digital output to trigger devices such as oscilloscopes, as well as trigger inputs to start acquisition and to tag data. The back panel has four additional analog instrument telegraph inputs, as well as a DB-25 connector for the digital outputs.
With its USB 2.0 interface, you can easily connect the Digidata 1440A Digitizer to a laptop computer without the need for a peripheral PC card.
Designed to support continuous data acquisition within a multitasking operating system, the Digidata 1440A Digitizer is fully compatible with the included AxoScope 10 Software for Microsoft Windows OS and the optional pCLAMP™ Electrophysiology Software for Windows.
Related Products
Data Acquisition
In combination with pCLAMP Software, the Digidata 1440A System forms the data acquisition backbone of an electrophysiology setup like those used in many labs around the world. The Clampex Data Acquisition Module, which is part of the pCLAMP Software, makes optimal use of the features of the Digidata 1440A Low-Noise Data Acquisition System.
Amplifiers
The Digidata 1440A System was designed to work with Axon electrophysiology amplifiers, such as the Multiclamp 700B Computer-Controlled Patch Clamp and Current Clamp Amplifier, the Axopatch 200B Capacitor Feedback Patch Clamp Amplifier, and the Axoclamp 900A Microelectrode Amplifier.
Analog signals from many other sources, such as transducers of physical parameters like pressure or light, can be acquired along with or instead of the electrophysiological signal. In combination with pCLAMP Software, analog and digital outputs can be used for sophisticated control of equipment in creative experiments.
- USB 2.0 connection allows operation on virtually any current PC computer running Microsoft Windows 2000 or XP Operating System, including laptops.
- Independent analog-to-digital converters for each input channel ensure low crosstalk levels and high data acquisition rates.
- 16-bit resolution for state-of-the-art signal-to-noise ratio
- 4 analog and 8 digital out channels to control the periphery equipment used in sophisticated experiments
- All signal connectors on the front panel for ease of access and maintenance of the electrophysiology setup
- Rack-mount case for tidy installation of all components in the electrophysiology setup
- User guide written by scientific consultants, with the assistance of Axon Instruments staff, for straightforward start-up and as an in-depth reference.
General Specifications
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Dimensions (in.)
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4.3 (H) x 19 (W) x 14.3 (D)
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Dimensions (cm)
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10.9 (H) x 48.3 (W) x 36.3 (D)
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Weight
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8 lbs. (3.6 kg)
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Communications
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USB 2.0
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Rack use
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Standard 19" rack-mount (2U) with handles
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Benchtop use
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Bayonet feet
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Power
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100-240 VAC 50-60 Hz, 115 W max
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Safety
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CE marking (Conformité Européenne)
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Detail Specifications
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Analog Inputs
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Number of input channels:
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16 single-ended
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Number of ADCs:
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16
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Sampling rates:
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1 Hz - 250 kHz; Maximum aggregate throughput
rate is 250 kHz x 16 input channels =
4 Megasamples/s
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Resolution:
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16-bit
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Input range:
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-10.000 V to
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+10.000 V
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Input resistance:
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1 MΩ
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Gain value:
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1
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Digital Inputs
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Number of bits:
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16
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Input type:
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TTL compatible
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Trigger Inputs
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Input type:
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TTL compatible
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TAG:
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rising-edge sensitive
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START:
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rising-edge sensitive
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Analog Outputs
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Number of channels:
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4
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Number of DACs:
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4
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Sampling rates:
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1 Hz - 250 kHz
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Resolution:
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16-bit
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Output range:
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-10.000 V to +10.000 V
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Output impedance:
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< 0.1Ω
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Output short circuit to signal ground:
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±25 mA
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Digital Outputs
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Number of bits:
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8 (of 16) supported in software
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SCOPE:
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dedicated trigger output
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Output driver:
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advanced CMOS (AC) compatible
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Output current:
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±4 mA source, ±32 mA sink
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Cable
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Type:
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USB 2.0 braided
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Length:
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3 meters
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System Requirements
Computer Specifications (Minimum)
- Windows 2000 SP4
- 1.2 GHz CPU
- 512 MB RAM
- 500 MB hard disk
- 1024 x 768 display
- CD-ROM drive
- 1 USB 2.0 port or 1 available PCI slot
Computer Specifications (Recommended)
- Windows XP Pro SP2 or Vista 32-bit
- 2.4 GHz CPU
- 1 GB RAM
- 32 GB hard disk
- 1024 x 768 display
- CD-ROM drive
- 2 built-in USB 2.0 ports
- Network connection
AxoScope 10 Software
AxoScope 10 Software is a turn-key data acquisition and analysis software for Microsoft Windows, designed to replace oscilloscopes, chart recorders, and FM tape recorders. AxoScope Software provides up to sixteen channels of analog acquisition and four different acquisition modes.
Data can be acquired and displayed continuously in Gap-Free mode up to the supported sampling rate of the digitizer. Other acquisition modes supported by AxoScope Software are threshold-triggered Fixed-Length Events, Variable-Length Events or High-Speed Oscilloscope modes. Tags and comments can be added to the data in real time. Analog output holding values can be altered.
AxoScope Software opens Axon-format ABF data files and enables quick analysis of sections of interest with an array of browsing and basic analysis tools. Data and page layout can be reviewed before printing. Additional features include voice tags, which allow tagging of data with spoken comments*, low-pass and high-pass digital filtering of incoming data, and Store Trace, which freezes a snapshot of a waveform on the screen for comparison with a subsequent input.
In combination with pCLAMP Software, the Digidata® 1440A System forms the data acquisition backbone of a setup like those used in many electrophysiology labs around the world. The Clampex Data Acquisition Module, which is part of the pCLAMP Software, makes optimal use of the features of the Digidata 1440A Low-Noise Data Acquisition System.
* Requires a sound chip in the host computer and a microphone
Developer Support
Software testbeds are available to help programmers write data acquistion programs for Digidata Digitizers. These testbeds include sample code and DLL drivers for Windows programs. For non-Windows programs, it is suggested that you write a C wrapper for our API.
There are two testbeds currently available through our Customer Support page:
- The Digidata 1440A Testbed allows programs to be created to control the Digidata 1440A Digitizer. The sample application requires a Digidata 1440A Digitizer to run.
- The Digidata 132x Testbed allows programs to be created to control the product line of Digidata 1320A, 1321A and 1322A digitizers. Note that the Adaptec WinASPI layer is also required.
Please note that technical support is not available for writing programs using these testbeds.
- Basic Ion Channel Research: Ion channels are pore proteins that are involved in a large variety of physiological processes. Basic research in the ion channel field furthers the understanding of ion channel function as well as their roles within cellular pathways and processes. Single-channel research helps with elucidating the mechanisms underlying ion channel function on a single-molecule level. Whole-cell and perforated patch clamp recordings are typically used to investigate the action of modulators on entire populations of ion channels in the membrane of a cell. Learn more.
- Cell Pathway Analysis: Ion channels are involved in many cell pathways and understanding the function of ion channels in response to changes in membrane potential or the presence or absence of other molecules is important in order to understand exactly how ion channels participate in normal and abnormal biological processes such as cell differentiation and migration, disease states, neuronal communications, etc. Learn more.
- Disease Research: Ion channels play a role in many diseases, including hypertension, cardiac arrhythmias, gastrointestinal, immune and neuromuscular disorders, pathological pain and cancer. By understanding the exact role that ion channels play in a particular disease, researchers might be able to find a way to affect the ion channel in such a way as to alter the course of the disease. Learn more.
- Safety Assessment: A critical part of drug discovery involves safety assessments, such as hERG testing, in order to eliminate any compounds with potential safety concerns. Conventional patch clamp has played an important role in collecting evidence for the absence of side effects before submission of a drug candidate to regulatory authorities. Even if automated electrophysiology has shifted safety testing to earlier stages in the drug discovery process, follow-up with conventional patch clamp is an essential step in the workflow. Learn more.
