Axon Patch Clamp Equipment
Ion channel dysfunction is associated with a broad range of human diseases including cystic fibrosis, migraine, cardiac arrhythmia, epilepsy, immune diseases and cancer, and research related to the study of the human senses: hearing, sight, smell, and taste. As a result, ion channels represent an attractive and promising class of targets for academic research. Both automated electrophysiology systems and conventional electrophysiology instruments are used to study ion channels and assay ion channel targets. With conventional techniques, scientists use microelectrode amplifiers to control the current and voltage in current-clamp and voltage-clamp mode and amplify the resultant signals while patching a cell. These amplified signals are digitized by a data acquisition system and acquired/analyzed using data acquisition/analysis software.test the reactions within the target and a digitizer to record the data Test the reactions within the target and utilize a digitizer to record the data.
Molecular Devices has many years of expertise in conventional electrophysiology, developing the first amplifier in 1983 under its Axon brand. Today, Molecular Devices offers a highly evolved line of microelectrode amplifiers for voltage recording, current clamps and voltage clamps, and patch clamping for ion channel research. The wide choice of headstages designed for specific applications and the many features that have been incorporated into the amplifiers make them ideal instruments on which to base an electrophysiology workstation. The amplifiers work in tandem with Molecular Devices' Digidata® 1440A Digitizer and pClamp Software for applications such as single channel recording, voltage clamp, whole cell patch clamp, current clamp recording, two electrode voltage clamp, and many more. basic ion channel research, cell pathway analysis, disease research, lead identification and optimization, and safety assessments.
The Axoporator® 800A System is the world's first commercially available micropipette-based system for single-cell electroporation, and is used primarily for the introduction of polar or charged molecules, such as drugs, proteins, peptides, or genes, into a cell.
Molecular Devices provides a broad range of instruments to meet the unique needs of ion channel researchers working with conventional electrophysiology methods, including our Axon line of products. Please use the links below to learn more about how we can support the success of your ion channel research efforts.
