Axon Conventional Electrophysiology

Axopatch 200B Amplifier - Product ImageAxon Axopatch 200B Capacitor Feedback Patch Clamp Amplifier

The benchmark for single-channel recordings and other applications where an excellent signal-to-noise ratio is key.

Widely accepted as the gold-standard for ultra low-noise patch clamp recordings, the Axopatch 200B Capacitor Feedback Patch Clamp Amplifier is the premier microelectrode amplifier for ultra-low noise patch clamp recordings. Incorporates capacitor-feedback technology and active headstage cooling for single-channel recording, while resistive-feedback circuitry is used for two different ranges of whole-cell recording. In current-clamp mode, offers two different speeds to optimize membrane potential recording, and allows correction for voltage errors due to pipette resistance. This makes the Axopatch 200B System the amplifier of choice for a scientist who performs basic research in the ion channel field and is the reason why researchers purchased thousands of these amplifiers from Molecular Devices over the past decade.


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  • Actively cooled capacitor-feedback headstage reduces thermal noise for signal-to-noise ratios close to the theoretical limits of physics
  • Integrating headstage mode for measuring sub-picoamp currents to enable high-fidelity single-channel recordings from cell membranes and artificial bilayers
  • Resistive headstage mode for larger currents and noise levels in whole-cell recordings
  • Slim headstage design for easier access to the preparation on a crowded microscope stage
  • Series resistance compensation: Prediction helps achieve the desired command level faster by transiently supercharging the membrane potential
  • Series resistance compensation: Correction improves the bandwidth of the recording by eliminating the error introduced by the voltage drop across the series resistance
  • Dual-speed current clamp optimizes speed and stability through better matching of the clamp algorithm to experimental parameters
  • Integrated seal test in voltage- and current-clamp mode for easy monitoring of membrane and cell health parameters
  • Dual command potentials add flexibility by processing input signals from two different sources
  • Selectable holding command input with two internal range settings and an external input enable convenient control of the output waveform
  • Pipette capacitance compensation neutralizes the contribution of the glass pipette and the pipette holder to the capacitance of the circuitry
  • Cell capacitance compensation corrects for the capacitance of the cell membrane in whole-cell recordings
  • Selectable output gain with 10 settings to scale the output signal to the desired level
  • Leak subtraction for correction of leak currents without software-based algorithms
  • Sophisticated 4-pole Bessel low-pass filter acts as anti-aliasing filter and can be used to pre-condition the output signal
  • Configurable panel meter displays user-selectable parameters in real time for quick monitoring of the experiment
  • Zap facilitates patch rupturing by applying a voltage pulse for a user-defined duration
  • Two included pipette holders of different barrel lengths accept glass pipettes in most standard dimensions
  • User guide written by scientific consultants, with the assistance of Axon Instruments staff, for straightforward start-up and as an in-depth reference

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Axopatch 200B Amplifier

Single-channel recording and whole-cell voltage-clamp recording

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