We offer one the broadest portfolios of bioanalytical products on the marketing today for drug discovery and basic life science research.
Key product categories include:
With almost 20 different models of single- and multi-mode microplate readers as well as microplate washers and handlers, industry-leading SoftMax Pro Data Analysis Software, and a suite of validation and compliance tools; we can meet all throughput, content, budget, and multiplexing needs of researchers who conduct microplate-based analyses. Researchers around the world rely on our products for microplate analysis for disease research, compound investigation, assay development, bioassay validation, quality assurance/quality control, biopharmaceutical manufacturing processes.
Our IonWorks® and PatchXpress® Automated Electrophysiology Systems are used globally to drive drug discovery & development, particularly discovery and screening programs focused on ligand- (including rapidly-desensitizing) and voltage-gated ion channels. We launched the first commercially-available automated electrophysiology system-the OpusXpress System-and have continued to deliver unique technologies that enable researchers to leverage the value of direct electrophysiological assays for their discovery research and screening assays. In addition, ion channel activity can be evaluated to predict potential safety concerns early in the drug discovery process. For example, by using our automated electrophysiology systems, researchers can conduct hERG channel assays to identify potential cardiac safety concerns before expensive toxicology studies are begun.
Under our Axon brand, we leverage more than 25 years of engineering and scientific expertise to deliver best-in-class microelectrode amplifiers, digital data recorders, electroporation systems, and data acquisition and analysis software to support basic life science research focused on the role of ion channels in a variety of normal and abnormal processes. Axon products are distinguished by their innovative design and exceptional quality and provide scientists with ready-to-use, technologically-advanced conventional patch clamp equipment to support an ever increasing array of research applications, including those focused on cell pathways, neurological, muscular, and gastrointestinal diseases, learning and memory, and many more.
High Content Screening is a powerful, automated cell biology method that enables researchers to collect and view data at the cellular and sub-cellular level. Originally developed as a complementary technology to traditional high throughput screening, today high content screening reaches into a much broader area of life science research as an unbiased method of imaging multiple cellular samples, multiplexing, and identifying and detecting "biosignatures." Our ImageXpress High Content Screening Systems and MetaXpress and AcuityXpress High Content Analysis Software Packages deliver top-of-the-line optical performance and precision to support a wide range of applications in drug discovery and basic life science research. In particular, High Content Imaging Systems and Software are ideal for the study of stem cells, RNAi, and cellular pathways as well as secondary screening programs and early safety assessments. No other technology allows researchers to easily obtain information at the cell population, single cell, and sub-cellular levels, making high content imaging a truly vital approach for all drug discovery & development and basic life science research efforts involving fixed cell or live cell analysis.
Our industry-leading MetaMorph® Imaging Acquisition and Analysis Software Suite supports a vast array of microscopes, cameras, and precision stages for researchers who investigate the cellular and biochemical processes underlying cellular function. The extensive suite of software provides acquisition, processing, and analysis features that allow researchers to build custom cellular imaging systems for solving novel experimental problems in cell biology.
The FLIPR® Tetra System is a high throughput screening system for real-time kinetic cellular assays. It has been optimized for use with both fluorescent and luminescent assays, including aequorin for GPCRs and ion channel screening. Molecular Devices also offers a large number of FLIPR Assay Kits for calcium mobilization and membrane potential analyses that further support GPCR and ion channel discovery research and screening programs.
The Threshold® System is a dedicated platform that offers two contaminant detection assays: the Threshold Immunoligand Assay (ILA) which measures a broad range of analytes such as proteins, peptides, and microorganisms for biopharmaceutical development and production and the Threshold Total DNA Assay which quantitatively measures picograms of single-stranded DNA with broad sequence specificity. This is an entirely unique system, delivering one of the best methods available to detect contaminants in biological samples and products.
GenePix Microarray Scanners accommodate any slide-based microarray analysis, from small one- or two-fluorescent applications to multiple-fluorescent, high throughput studies. When combined with GenePix Pro Data Acquisition and Analysis and Acuity Informatics Software, these scanners offer a complete solution for research focused on functional biology, genomics, genetics, transcriptomics, proteomics, and comparative genomic hybridization (CGH).
The CellKey® System leverages a unique impedance-based technology to determine impedence profiles that provide detailed information about the activities of cellular pathways. The system is ideal for GPCR and ion channel drug discovery programs from target identification and validation to lead optimization. In particular, this system is invaluable for researchers interested in deciphering Gi/Go pathways.
We offer a broad range of bioanalytical assay kits that enable researchers to study molecular function and pathway analysis, particularly efforts focused on calcium mobilization, ion channel activity and function, GPCR biology, and transporter function. In addition, researchers can leverage our assay kits to measure contamination levels in food and water, detect host cell DNA introduced during the biopharmaceutical manufacturing process, and assess kinase, phosphatase, and phosphodiesterase enzyme activity.