Benefits of Label-Free Impedance Analysis for Complex GPCR Biology

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Panelist Information:      
Ryan McGuinness
Emmanuel Sturchler, Ph.D,


Description:      
The past decade has seen a growing understanding that the complexity of GPCR pharmacology is far greater than anticipated, and that assays which examine only single-points in signaling pathways do not address this complexity. Having a greater understanding of G-protein signal transduction mechanisms and the impact that these mechanisms can have on data interpretation is key to the future success of GPCR drug discovery. Label-free cell-based assays reflect the integrated whole-cell response to stimulus and provide an important tool in the arsenal of applications available for scientists involved in GPCR drug discovery. Join speakers from Scripps Research Institute and Molecular Devices to learn more about successes in leveraging impedance-based label-free technology for understanding the deep complexity underlying GPCR biology. Topics will include discussion of the unique applications of the CellKey® System for study of receptor-associated behaviors, including pleiotropic signaling, functional selectivity, and allosteric modulator activities.

Agenda:

Introduction
Debra Gallant, Molecular Devices, Inc.

Harnessing the Benefits of GPCR Complexity with the CellKey® System
Ryan McGuinness, Sr. Application Scientist, Molecular Devices

Characterization of GABA-B receptor allosteric modulators using the CellKey® System
Emmanuel Sturchler, Ph.D., Research Associate, Drug Discovery Department, Scripps Research Institute, Florida