Microplate-Based Analyses

Drug discovery research requires instrumentation to be both functional and versatile. Regardless of the assay protocol, the end result is measurement by some sort of detection device. Most drug discovery researchers prefer homogenous assays that are conducted in microplates to maximize throughput, followed by quantification of an absorbance, fluorescence, or luminescence signal.

In a high-throughput screening (HTS) environment, microplate-based assays are developed to make determinations on large numbers of samples. And, as researchers gain a greater understanding of the complexity of biological pathways, the capability to detect multiple signals in one microplate-based assay is increasingly important. As such, multi-detection, or multi-mode, microplate readers are a system of choice for assay development in both low- and high-throughput formats. 

Multi-mode microplate readers include different combinations of detection modes for absorbance, luminescence, fluorescence intensity, time-resolved fluorescence, and fluorescence polarization depending on the configuration of the individual system. The addition of compatible robots, such as microplate handlers and washers, allows varying degrees of unattended operation to support high-throughput screening.

Typical microplate-based assays include antibody-antigen binding, receptor-liquid binding, ELISA and Elispot, nucleic acid quantification using fluorescent dyes or direct UV analysis, and more.  

Molecular Devices introduced its first microplate reader in 1987. Today, Molecular Devices provides 9 models of single-mode microplate readers and 9 configurations of multi-mode readers. In addition, we provide microplate handlers and washers as well as automation solutions via trusted automation partners.

SpectraMax® M2/M2e Microplate Reader

SpectraMax® M3 Microplate Reader

SpectraMax® M4 Microplate Reader

SpectraMax® M5/M5e Microplate Reader

AquaMax® 2000/4000 Microplate Washers

StakMax® Microplate Handling System

FlexStation® 3 Benchtop Multi-Mode Microplate Reader 

FLIPR® Tetra High-Throughput Cellular Screening System