Translation refers to the application of results of basic biomedical research to the practice of medicine. More specifically, it describes the process of converting laboratory discoveries into clinical interventions that provide a direct benefit to human health. Over the past decade, the definition of translational research has become broader and now often refers to research that facilitates or enables the more rapid or more effective transition of basic research results toward large scale evaluation and validation for use in or for humans.
The current drug discovery and development process includes five basic translational steps: 1) from physiochemical properties to biology, 2) from in vitro to in vivo studies, 3) from animals to healthy human volunteers, 4) from single dose to multiple doses, and 5) from healthy volunteers to patients. For the most part, researchers are focusing translational research efforts on the transition from animals to humans as this is generally considered the step with the greatest challenges.
One intriguing aspect of translational research is that it sits right between what has traditionally been thought of as the domain of the pharmaceutical and biotechnology industry and that of academia. With the increased pressure on the drug discovery industry to cut costs, speed time to market, and reduce attrition rates, quick and effective translations from one step of the process to the next will become more crucial. It is likely that industry and academia will be forging more alliances and collaborations in order to achieve this objective. It is also highly likely that biomarkers will become a critical element of successful translations of research.
Molecular Devices is well positioned to support the needs of both academia and industry when it comes to translational research. We provide a wide range of technologies that help you generate more physiologically-relevant results, including live cell capabilities and label-free analytical systems. We also have a long and respected history of providing advanced detection capabilities--from dedicated, single readout instruments to automated, multi-detection systems.
As a result, we are an ideal choice to support your biomarker discovery programs as well as the successful translation of your research results into impactful interventions that will improve human health. Please select among the links below to learn more.